Protein Alignment mid and TBX15

DIOPT Version :10

• Sequence 1: NP_608927.2
• Gene: mid / 33770
• FlyBaseID: FBgn0261963
• Length: 580
• Species: Drosophila melanogaster
• Sequence 2: XP_047285080.1
• Gene: TBX15 / 6913
• HGNCID: 11594
• Length: 698
• Species: Homo sapiens
• Alignment Length: 531
• Identity: 187/531 - (35%)
• Similarity: 261/531 - (49%)
• Gaps: 110/531 - (20%)

  Fly   128 QTASAESQLNTSSTSSQGRCSTPPQSPGTEDSEERLTPEPVQKAPKIVGSCNCDDLKPVQCHLET 192
            |:..::|::.|..||    ||.   |..|:.:.....|.|...:          .::.:|..|:.
Human   135 QSTGSDSEVLTERTS----CSF---STHTDLASGAAGPVPAAMS----------SMEEIQVELQC 182

  Fly   193 KELWDRFHDLGTEMIITKTGRRMFPTVRVSFSGPLRQIQPADRYAVLMDIIPMDSKRYRYAYHRS 257
            .:||.||||:||||||||.||||||.:||..:|    :.|..:|.:.|||:|:|:|||||.||.|
Human   183 ADLWKRFHDIGTEMIITKAGRRMFPAMRVKITG----LDPHQQYYIAMDIVPVDNKRYRYVYHSS 243

  Fly   258 AWLVAGKADPAPPARLYAHPDSPFSCEALRKQVISFEKVKLTNNEMDKNGQIVLNSMHRYQPRIH 322
            .|:|||.||...|.|:|.||||..|.:...:||:||:|:||||||:|..|.|:|:|||:||||:|
Human   244 KWMVAGNADSPVPPRVYIHPDSLASGDTWMRQVVSFDKLKLTNNELDDQGHIILHSMHKYQPRVH 308

  Fly   323 LVRLSHGQSI-PSNPKELQDLDHKTYVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDSSRLT 386
            ::|......: |:.|..:.| ..||:.|||||||.|||||||.||:||||.||||||||||.|
Human   309 VIRKDFSSDLSPTKPVPVGD-GVKTFNFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRDSGR-- 370

  Fly   387 DFDRDPMEALLLEQQL-RSPLR--LFPD--PLMQQFA----AQG--------DPSSMALFEKARQ 434
              :|..:||::..... |.|:|  .|.|  .:.:|.|    :||        :..::.|:|:...
Human   371 --NRTGLEAIMETYAFWRPPVRTLTFEDFTTMQKQQASKKTSQGYTVNQHSSETDAIELYERRVW 433

  Fly   435 HLQMFG--GNSPYAQLMMPQMYQAAAAAAGPPPPPPGLGAFHMFQQQW------PQLTAGFLASA 491
            .::..|  |.||...........|::....|...||   .||:....:      .||....|:..
Human   434 LMERRGSTGTSPTTSSTGTPSPSASSHLLSPSCSPP---TFHLAPNTFNVGCRESQLCNLNLSDY 495

  Fly   492 NQQAAAAQAAAQA----------QAQAQAAAAAMAA-----NRTP------PPPPT--------- 526
            ...|.:..||.|:          :.|:...:|...:     .|||      |.||:
Human   496 PPCARSNMAALQSYPGLSDSGYNRLQSGTTSATQPSETFMPQRTPSLISGIPTPPSLPGNSKMEA 560

  Fly   527 -----ASTPSS------------TSSGSP----SPDMRPRQYQRFS---PYQLPGGQGPPS-SAA 566
                 .|.|:|            :||.||    ...|:...|..||   ||.|.|...|.| ..|
Human   561 YGGQLGSFPTSQFQYVMQAGNAASSSSSPHMFGGSHMQQSSYNAFSLHNPYNLYGYNFPTSPRLA 625

  Fly   567 GSPPAVNASRS 577
            .||..::||:|
Human   626 ASPEKLSASQS 636

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mid	NP_608927.2	T-box_TBX20-like	186..382	CDD:410319	111/196 (57%)
TBX15	XP_047285080.1	T-box_TBX15-like	170..367	CDD:410324	110/211 (52%)