Protein Alignment mid and TBX2

DIOPT Version :9

• Sequence 1: NP_001260096.1
• Gene: mid / 33770
• FlyBaseID: FBgn0261963
• Length: 580
• Species: Drosophila melanogaster
• Sequence 2: NP_005985.3
• Gene: TBX2 / 6909
• HGNCID: 11597
• Length: 712
• Species: Homo sapiens
• Alignment Length: 641
• Identity: 196/641 - (30%)
• Similarity: 257/641 - (40%)
• Gaps: 227/641 - (35%)

  Fly   122 SGGAVAQTASAESQLNTSSTSSQGRCSTPPQSPGTE-DSEERLTPE-PVQKAPKIVGSCNCDDLK 184
            :..|.|..|:||:.|:.|:..        |..|... .|.:.|.|| .|:..||:.
Human    61 AAAAAAAAAAAEAGLHVSALG--------PHPPAAHLRSLKSLEPEDEVEDDPKVT--------- 108

  Fly   185 PVQCHLETKELWDRFHDLGTEMIITKTGRRMFPTVRVSFSGPLRQIQPADRYAVLMDIIPMDSKR 249
                 ||.|||||:||.|||||:|||:||||||..:|..||    :....:|.:||||:..|..|
Human   109 -----LEAKELWDQFHKLGTEMVITKSGRRMFPPFKVRVSG----LDKKAKYILLMDIVAADDCR 164

  Fly   250 YRYAYHRSAWLVAGKADPAPPARLYAHPDSPFSCEALRKQVISFEKVKLTNNEMDKNGQIVLNSM 314
            |:  :|.|.|:|||||||..|.|:|.|||||.:.|....:.::|.|:|||||..||:|..:||||
Human   165 YK--FHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFTILNSM 227

  Fly   315 HRYQPRIHLVRLSHGQSIPSNPKELQDLDHKTYVFPETVFTAVTAYQNQLITKLKIDSNPFAKGF 379
            |:||||.|:||.:....:|.:       ..:|||||||.|.|||||||..||:||||:|||||||
Human   228 HKYQPRFHIVRANDILKLPYS-------TFRTYVFPETDFIAVTAYQNDKITQLKIDNNPFAKGF 285

  Fly   380 RD---------------SSRLTD------------------------------------------ 387
            ||               |.||.:
Human   286 RDTGNGRREKRKQLTLPSLRLYEEHCKPERDGAESDASSCDPPPAREPPTSPGAAPSPLRLHRAR 350

  Fly   388 -------FDRDPMEALLLEQQLRSPLRLFPDPLMQQFAAQGDPSSMALFEKARQHLQ-------- 437
                   .|.||....|.|::..:||...|.|      ....|:.:...|:||:...
Human   351 AEEKSCAADSDPEPERLSEERAGAPLGRSPAP------DSASPTRLTEPERARERRSPERGKEPA 409

  Fly   438 MFGGNSPYA--------------------------QLMMPQMYQAAAAAAGPPPPPPGLGAF--H 474
            ..||:.|:.                          |.:.|.:.|..:|:.......||| ||  |
Human   410 ESGGDGPFGLRSLEKERAEARRKDEGRKEAAEGKEQGLAPLVVQTDSASPLGAGHLPGL-AFSSH 473

  Fly   475 MFQQQW--------------PQLTAG-----------FLASA----------------------N 492
            :..||:              .|.|.|           .|||.                      .
Human   474 LHGQQFFGPLGAGQPLFLHPGQFTMGPGAFSAMGMGHLLASVAGGGNGGGGGPGTAAGLDAGGLG 538

  Fly   493 QQAAAAQAAA-------QAQAQAQA-----------------AAAAMAANRTPPPPPTASTPSST 533
            ..|:||..||       |....:|.                 ||||.||:..|.....|:..::.
Human   539 PAASAASTAAPFPFHLSQHMLASQGIPMPTFGGLFPYPYTYMAAAAAAASALPATSAAAAAAAAA 603

  Fly   534 SSGSPSP---DMRPRQYQRFSPYQLPGGQGPPSS-------AAGSPPAVNASRSPA 579
            .|.|.||   ..|||  .||||||:|....|.:|       :.||..|...||.|:
Human   604 GSLSRSPFLGSARPR--LRFSPYQIPVTIPPSTSLLTTGLASEGSKAAGGNSREPS 657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mid	NP_001260096.1	TBOX	185..384	CDD:238106	107/213 (50%)
TBX2	NP_005985.3	T-box_TBX2_3-like	103..287	CDD:410314	106/210 (50%)
		PHA03307	300..>467	CDD:223039	23/172 (13%)
		TBX	305..383	CDD:403708	11/83 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	313..450		17/142 (12%)
		Repression domain 1 (RD1)	518..601		15/82 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	637..687		6/21 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141523
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740