Protein Alignment mid and Tbr1

DIOPT Version :10

• Sequence 1: NP_608927.2
• Gene: mid / 33770
• FlyBaseID: FBgn0261963
• Length: 580
• Species: Drosophila melanogaster
• Sequence 2: NP_001177999.2
• Gene: Tbr1 / 680427
• RGDID: 1591773
• Length: 681
• Species: Rattus norvegicus
• Alignment Length: 572
• Identity: 178/572 - (31%)
• Similarity: 226/572 - (39%)
• Gaps: 139/572 - (24%)

  Fly    98 QHHQHHHNNNNNNNNNNVAHKSRNSGGAVAQTASAESQLNTSSTSSQGRCSTP-PQSPGTEDSEE 161
            ||...|...:..:.:..:||....:.||.      .|.|:.||.........| ||..|
  Rat   129 QHGPAHPAFSIGSPSRYMAHHPVITNGAY------NSLLSNSSPQGYPTAGYPYPQQYG------ 181

  Fly   162 RLTPEPVQKAPKIVGSCNCDDLKP--VQCHLETKELWDRFHDLGTEMIITKTGRRMFPTVRVSFS 224
                ...|.||....|.....|.|  .|.:|..:.||.:||...|||||||.||||||.:..:.|
  Rat   182 ----HSYQGAPFYQFSSTQPGLVPGKAQVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNIS 242

  Fly   225 GPLRQIQPADRYAVLMDIIPMDSKRYRYAYHRSAWLVAGKADP-APPARLYAHPDSPFSCEALRK 288
            |    :.|...|.:.:|:|..|...:|  :....|:..||||. ....|:|.|||||.:.....:
  Rat   243 G----LDPTAHYNIFVDVILADPNHWR--FQGGKWVPCGKADTNVQGNRVYMHPDSPNTGAHWMR 301

  Fly   289 QVISFEKVKLTNNE--MDKNGQ-IVLNSMHRYQPRIHLVRLSH-GQSIPSNPKELQDLDHKTYVF 349
            |.|||.|:|||||:  .:.||| :||.|:|:||||:|:|.::. |....|.|..:|     |:.|
  Rat   302 QEISFGKLKLTNNKGASNNNGQMVVLQSLHKYQPRLHVVEVNEDGTEDTSQPGRVQ-----TFTF 361

  Fly   350 PETVFTAVTAYQNQLITKLKIDSNPFAKGFRDS----------SRLTDFDRD------------P 392
            |||.|.|||||||..||:||||.|||||||||:          .|||....|            .
  Rat   362 PETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDTIYTGCDMDRLTPSPNDSPRSQIVPGARYA 426

  Fly   393 MEALLLEQQLRS---PLRLFP-----------------DPLM--QQFAAQGDPSSMALF-EKARQ 434
            |....|:.|..|   ..|..|                 :.|:  ||....|.||....| ..|..
  Rat   427 MAGSFLQDQFVSNYAKARFHPGAGAGPGPGTDRSVPHTNGLLSPQQAEDPGAPSPQRWFVTPANN 491

  Fly   435 HLQM----------FGGNS----PYAQLMMPQMYQAAAAAAGPP----PPPPGLGAFHMFQQQWP 481
            .|..          |.||:    .||...:..:...||...|.|    ..|.|.||     :..|
  Rat   492 RLDFAASAYDTATDFAGNAATLLSYAAAGVKALPLQAAGCTGRPLGYYADPSGWGA-----RSPP 551

  Fly   482 QLTAGFLASA-----NQQAAAAQAAAQAQAQAQAAAAAMAANRTPPPPPT-------------AS 528
            |.......|.     |..||||:.|. |.......|..:||.|:|..|..             ..
  Rat   552 QYCGAKSGSVLPCWPNSAAAAARMAG-ANPYLGEEAEGLAAERSPLAPAAEDAKPKDLSDSSWIE 615

  Fly   529 TPSSTSS--GSPSPDMRPRQYQRFSPYQLPGGQGPPSSAAGSPPAVNASRSP 578
            ||||..|  .|.|......:.:|.||...|               |:.|.||
  Rat   616 TPSSIKSIDSSDSGIYEQAKRRRISPADTP---------------VSESSSP 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mid	NP_608927.2	T-box_TBX20-like	186..382	CDD:410319	93/200 (47%)
Tbr1	NP_001177999.2	T-box_TBR1	203..393	CDD:410330	92/200 (46%)
		T-box_assoc	418..679	CDD:465042	59/256 (23%)