Protein Alignment mid and tbr1b

DIOPT Version :10

• Sequence 1: NP_608927.2
• Gene: mid / 33770
• FlyBaseID: FBgn0261963
• Length: 580
• Species: Drosophila melanogaster
• Sequence 2: NP_001108562.1
• Gene: tbr1b / 58042
• ZFINID: ZDB-GENE-000323-1
• Length: 676
• Species: Danio rerio
• Alignment Length: 655
• Identity: 190/655 - (29%)
• Similarity: 261/655 - (39%)
• Gaps: 166/655 - (25%)

  Fly     1 MLVGSHPYLCNGVPAAPAAPNA-----------SGQTTTTASKSAAGSATDFSIAAIMAREDASS 54
            |:|||      |.|.|.|:..|           :.:.::...|::|| .|:.|.|...|....||
Zfish    18 MIVGS------GYPNAQASELALQDYPIISIGDNLERSSPLKKNSAG-MTNQSEADNFADSKDSS 75

  Fly    55 RESSIRSASPISVEDEVDVDVV-------DCSDAEE---------PPTKARRLNHHQHH------ 97
            .:......||       |:|.|       |.|..|.         .|:......:...|
Zfish    76 GDVQRGKLSP-------DLDGVADSRHTFDGSAGERYLLSQSSQVQPSPTTMFPYPSQHGPTHPA 133

  Fly    98 ------QHHQHHHNNNNNNNNNNVAHKSRNSGGAVAQTASAESQLNTSSTSSQGRCSTPPQSPGT 156
                  ..:..||....|...|::...|...|.|.|....|:...:....::..:.|:
Zfish   134 FSIASPSRYMAHHPVITNGAYNSLLSNSSPQGYATAGYPYAQQYGHAYQGTAFYQFSS------- 191

  Fly   157 EDSEERLTPEPVQKAPKIVGSCNCDDLKPVQCHLETKELWDRFHDLGTEMIITKTGRRMFPTVRV 221
              ::..|.|...|     |..||             :.||.:||...|||||||.||||||.:..
Zfish   192 --AQAGLVPGKAQ-----VYLCN-------------RALWLKFHRHQTEMIITKQGRRMFPFLSF 236

  Fly   222 SFSGPLRQIQPADRYAVLMDIIPMDSKRYRYAYHRSAWLVAGKADP-APPARLYAHPDSPFSCEA 285
            :.||    :.|...|.:.:|:|..|...:|  :....|:..||||. ....|:|.|||||.:...
Zfish   237 NISG----LDPTAHYNIFVDVILADPNHWR--FQGGKWVPCGKADTNVTGNRVYMHPDSPNTGAH 295

  Fly   286 LRKQVISFEKVKLTNNE--MDKNGQ-IVLNSMHRYQPRIHLVRLSH-GQSIPSNPKELQDLDHKT 346
            ..:|.|||.|:|||||:  .:..|| :||.|:|:||||:|:|:::. |....|.|..:|     |
Zfish   296 WMRQEISFGKLKLTNNKGATNNTGQMVVLQSLHKYQPRLHVVQVNEDGTEDTSQPGRVQ-----T 355

  Fly   347 YVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDS----------SRLTDFDRDPMEALLLEQQ 401
            :.||||.|.|||||||..||:||||.|||||||||:          .|||....|...:.::...
Zfish   356 FTFPETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDTVYTGCDIDRLTPSPGDSPRSQIMPSA 420

  Fly   402 LRSPLRLFPDPLMQQFAAQGDPSSMALFEKARQHLQMFGG-----NSPYA-QLMMPQMYQAAAAA 460
            ..:....|   |..||.:.        :.|:|.|..:.|.     :.|.: .|:.||..:....|
Zfish   421 RYAMTGSF---LQDQFVSS--------YAKSRFHPGVGGAPGTDRSVPLSNSLLSPQQTEETTVA 474

  Fly   461 AGPPPPPPGLGAFHMFQQQWPQLTAG----FLASANQQAAAAQAAAQAQAQAQAAAAAMAA---- 517
            :               .|:|....|.    |.|||...||||..|..|......|||.:.|
Zfish   475 S---------------PQRWFVTPANNRLDFAASAYDAAAAADFAGNAATLLSYAAAGVKALPLP 524

  Fly   518 -----NR------TPP------PPPTASTPSSTSSGSPSPDMRPRQYQRFSPYQLPG-GQGPPSS 564
                 ||      .||      ||...|..||..|..||..:..|  ...|.|.:|| ..|.|.:
Zfish   525 GAGCSNRPLGYYGEPPGWGTRTPPQYCSKSSSVLSCWPSNSVGSR--TTASSYLVPGLEDGDPIA 587

  Fly   565 AAGSP 569
            ...||
Zfish   588 PERSP 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mid	NP_608927.2	T-box_TBX20-like	186..382	CDD:410319	90/200 (45%)
tbr1b	NP_001108562.1	T-box	200..390	CDD:469628	93/218 (43%)
		T-box_assoc	415..674	CDD:465042	51/206 (25%)