DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mid and tbx2a

DIOPT Version :9

Sequence 1:	NP_001260096.1	Gene:	mid / 33770	FlyBaseID:	FBgn0261963	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	XP_005165613.1	Gene:	tbx2a / 573084	ZFINID:	ZDB-GENE-990917-4	Length:	690	Species:	Danio rerio

Alignment Length:	586	Identity:	173/586 - (29%)
Similarity:	224/586 - (38%)	Gaps:	226/586 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 EPVQKAPKIVGSCNCDDLKPVQCHLETKELWDRFHDLGTEMIITKTGRRMFPTVRVSFSGPLRQI 230
            |.|:..||:.              ||.|||||:||.:||||:|||:||||||..:|..:|    :
Zfish    87 EDVEDDPKVT--------------LEAKELWDQFHKIGTEMVITKSGRRMFPPFKVRVNG----L 133

  Fly   231 QPADRYAVLMDIIPMDSKRYRYAYHRSAWLVAGKADPAPPARLYAHPDSPFSCEALRKQVISFEK 295
            ....:|.:||||:..|..||:  :|.|.|:|||||||..|.|:|.|||||.:.|....:.::|.|
Zfish   134 DKKAKYILLMDIVAADDCRYK--FHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHK 196

  Fly   296 VKLTNNEMDKNGQIVLNSMHRYQPRIHLVRLSHGQSIPSNPKELQDLDHKTYVFPETVFTAVTAY 360
            :|||||..||:|..:|||||:||||.|:||.:....:|.:       ..:|||||||.|.|||||
Zfish   197 LKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYS-------TFRTYVFPETDFIAVTAY 254

  Fly   361 QNQLITKLKIDSNPFAKGFRD-------------------SSRLTD----FDRD----------- 391
            ||..||:||||:|||||||||                   |.|:.|    .|||
Zfish   255 QNDKITQLKIDNNPFAKGFRDTGNGRREKSLNFRKQLAMPSMRMYDDQCKVDRDGGDSDDSSCEQ 319

  Fly   392 ------------PMEALLL------------------------------EQQLRSPL-------- 406
                        |..:.|.                              ||:.:||.
Zfish   320 TTGRDSVHSPTGPATSPLKFTRSREDKNFNESDNELDQHDDGMIRVSSPEQRPQSPFSPRCEDRV 384

  Fly   407 --RL-------FPD-----------------------------------------------PLMQ 415
              ||       :.|                                               |||.
Zfish   385 KDRLNLEKKGDYSDSRKENDSAFSIRHLDKDKLDARNVKDQDSSKKEADSVGMSTVKDGFSPLMV 449

  Fly   416 Q------FAAQGDPSSMALFEKARQHL---------------QMFGGNSPYAQLMMPQMYQAAAA 459
            |      |:| ....|:||.....||.               |.....|.::.:.|..:..:.:.
Zfish   450 QTENPSHFSA-SHLQSLALSGLHNQHFFNPLSSGQSLLFHPGQFAMTPSAFSTMGMGHLLASMSG 513

  Fly   460 AAG------------PPPPPPGLGAFHMFQQQWPQLT--AGFLASANQQAAAAQAAAQAQAQAQA 510
            |:|            .|.|.|...:.||...|...:.  .|.|.......|||.|||.|.
Zfish   514 ASGLENGSLSSQSTSSPNPFPFHLSQHMLASQGISMPTFGGLLPYPYTYMAAAAAAASAL----- 573

  Fly   511 AAAAMAANRTPPPPPTASTPSSTSSGSPSPDMRPRQYQRFSPYQLPGGQGPPSS--AAGSPPAVN 573
                          |..|..||.|......:.|||  .||||||:|......|.  ..|.|..::
Zfish   574 --------------PAGSAASSLSRNPFLNNTRPR--LRFSPYQIPMSFSQSSGLLTTGIPSTMS 622

  Fly   574 A 574
            |
Zfish   623 A 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mid	NP_001260096.1	TBOX	185..384	CDD:238106	105/217 (48%)
tbx2a	XP_005165613.1	TBOX	92..277	CDD:238106	106/211 (50%)
tbx2a	XP_005165613.1	TBX	297..372	CDD:204975	9/74 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574487
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740