Protein Alignment mid and Tbx1

DIOPT Version :10

• Sequence 1: NP_608927.2
• Gene: mid / 33770
• FlyBaseID: FBgn0261963
• Length: 580
• Species: Drosophila melanogaster
• Sequence 2: NP_001402633.1
• Gene: Tbx1 / 360737
• RGDID: 1307734
• Length: 530
• Species: Rattus norvegicus
• Alignment Length: 610
• Identity: 197/610 - (32%)
• Similarity: 254/610 - (41%)
• Gaps: 173/610 - (28%)

  Fly    33 SAAGSATDFSIAAIMAREDASSRESSIRSASPISVEDEVDVDVVDCSDAEEPPTKARRLNHHQHH 97
            ||..||  ||||:::|.|  :|..::.|...|              ||.    .|.|||......
  Rat     8 SARASA--FSIASLVAAE--ASEGTAHRGPRP--------------SDR----AKLRRLPGSPAG 50

  Fly    98 QHHQHHHNNNNNNNNNNVAHKSRNSGGAVAQTASAESQLNTSS-------------------TSS 143
            .|.                  |..:....|..||:.|.|...|                   |::
  Rat    51 MHF------------------STVTRDMEAFAASSLSGLGAPSPGADPFGPREPPPPRYDPCTAA 97

  Fly   144 QGRCSTPP-------------------QSPGTEDSEERLTPEPVQKAPKIVGSCNCDDLKPVQCH 189
            .|....||                   :|.|...|.......||:|.||:..         |...
  Rat    98 PGAPGPPPPPRAYPFAPAPGAASSSAAESEGPGASRAAAAKAPVKKNPKVAS---------VSVQ 153

  Fly   190 LETKELWDRFHDLGTEMIITKTGRRMFPTVRVSFSGPLRQIQPADRYAVLMDIIPMDSKRYRYAY 254
            ||.|.|||.|:.||||||:||.|||||||.:|...|    :.|...|.:|||.:|:|.||||||:
  Rat   154 LEMKALWDEFNQLGTEMIVTKAGRRMFPTFQVKLFG----MDPMADYMLLMDFVPVDDKRYRYAF 214

  Fly   255 HRSAWLVAGKADPAPPARLYAHPDSPFSCEALRKQVISFEKVKLTNNEMDKNGQIVLNSMHRYQP 319
            |.|:||||||||||.|.|::.|||||.......||::||:|:|||||.:|.||.|:|||||||||
  Rat   215 HSSSWLVAGKADPATPGRVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHIILNSMHRYQP 279

  Fly   320 RIHLVRLSHGQSIPSNPKELQDLDHKTYVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDSSR 384
            |.|:|.:...:......:|    :.||:||.||.|||||||||..||:|||.||||||||||...
  Rat   280 RFHVVYVDPRKDSEKYAEE----NFKTFVFEETRFTAVTAYQNHRITQLKIASNPFAKGFRDCDP 340

  Fly   385 LTDFDRDPMEALLLEQQLRSPLRLFPDPLMQQFAAQGDPSSMAL--------FEKARQHLQMFGG 441
             .|:.|:.....|              ||:..||...:|.:...        ..:||:......|
  Rat   341 -EDWPRNHRPGAL--------------PLVSAFARSRNPVASPTQPNGADKDVAEARREFDRDSG 390

  Fly   442 NSPYA--------QLMMPQMYQAAAAAAGPPPPPPGLGAFHMFQQQWPQLTAGFLASANQQAAAA 498
              |.|        ||:...:..|.....|..|.|.|.|..|
  Rat   391 --PAALGDATHPPQLLARVLSPALPGPGGLVPLPGGSGGRH------------------------ 429

  Fly   499 QAAAQAQAQAQAAAAAMAANRTPPPPPTASTPSSTSSGSPSPDMRPRQYQRFSPYQLPG----GQ 559
             :...|..:.:|..|:...:..|...|.|:......:.|     ||      :||.|||    |.
  Rat   430 -SPPHADLRLEAPGASEPLHHHPYKYPAAAYDHYLGAKS-----RP------APYPLPGLRGHGY 482

  Fly   560 GPPSSAAGSP-----PAVNASRSPA 579
            .|.:.....|     ||||.:.:.|
  Rat   483 HPHAHPHAHPHHHHHPAVNPAAAAA 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mid	NP_608927.2	T-box_TBX20-like	186..382	CDD:410319	113/195 (58%)
Tbx1	NP_001402633.1	T-box_TBX1_10-like	150..337	CDD:410313	112/194 (58%)