Protein Alignment mid and TBX10

DIOPT Version :10

• Sequence 1: NP_608927.2
• Gene: mid / 33770
• FlyBaseID: FBgn0261963
• Length: 580
• Species: Drosophila melanogaster
• Sequence 2: XP_047282835.1
• Gene: TBX10 / 347853
• HGNCID: 11593
• Length: 676
• Species: Homo sapiens
• Alignment Length: 584
• Identity: 187/584 - (32%)
• Similarity: 248/584 - (42%)
• Gaps: 166/584 - (28%)

  Fly    21 NASGQTTTTASKS--AAGSA-----TDFSIAAIMAREDASSRESSI-------------RSASPI 65
            ::|.:.|||:.:.  |...|     .|:|:...:   |||.:.||:             ..|.|.
Human   199 SSSSRKTTTSGRGRRAIEEARTVLPRDYSLYLTL---DASGKLSSLGPEECWLLEGLSKGQAPPT 260

  Fly    66 SVEDEVDVDVVDC-------SDAEEP---PTKARRLNHHQHHQHHQHHHNNNNNNNNNNVAHKSR 120
            .|.:.|:...:.|       .||..|   |.....|
Human   261 RVPESVEGQHIGCDGQRSWLGDAWGPHFRPLSTAFL----------------------------- 296

  Fly   121 NSGGAVAQTASAESQLNTSSTSSQGRCSTP-PQSPGTEDSEERLTPEPVQKAPKIVGSCNCDDLK 184
             |.|......|....|.|:|:..:.|..:| |..|.|..:..:...||..:.||          .
Human   297 -SAGLGILAPSETYPLPTTSSGWEPRLGSPFPSGPCTSSTGAQAVAEPTGQGPK----------N 350

  Fly   185 P----VQCHLETKELWDRFHDLGTEMIITKTGRRMFPTVRVSFSGPLRQIQPADRYAVLMDIIPM 245
            |    |...||.|.||:.|:.||||||:||.||||||..:|...|    :.....||:|||.||:
Human   351 PRVSRVTVQLEMKPLWEEFNQLGTEMIVTKAGRRMFPPFQVKILG----MDSLADYALLMDFIPL 411

  Fly   246 DSKRYRYAYHRSAWLVAGKADPAPPARLYAHPDSPFSCEALRKQVISFEKVKLTNNEMDKNGQIV 310
            |.||||||:|.||||||||||||.|.|::.|||||.......:|::||:|:|||||.:|.||.|:
Human   412 DDKRYRYAFHSSAWLVAGKADPATPGRVHFHPDSPAKGAQWMRQIVSFDKLKLTNNLLDDNGHII 476

  Fly   311 LNSMHRYQPRIHLVRLSHGQSIPSNPKELQDLDHKTYVFPETVFTAVTAYQNQLITKLKIDSNPF 375
            ||||||||||.|:|.:...:......:|    :.|:::|.||.|||||||||..||:|||.||||
Human   477 LNSMHRYQPRFHVVFVDPRKDSERYAQE----NFKSFIFTETQFTAVTAYQNHRITQLKIASNPF 537

  Fly   376 AKGFRDSSRLTDFDRDPMEAL-LLEQQLRSPLRLFPDPLMQQFAAQGDPSSMALFEKARQHLQMF 439
            |||||:|    |.|..|:... ||....||...|.|..|......:.||:
Human   538 AKGFRES----DLDSWPVAPRPLLSVPARSHSSLSPCVLKGATDREKDPN--------------- 583

  Fly   440 GGNSPYAQLMMPQMYQAAAAAAGPP--------PPPPGLGAFHMFQQQWPQLTAGFLASANQQAA 496
                           :|:|:.:..|        |||..|                 ||.|..:..
Human   584 ---------------KASASTSKTPAWLHHQLLPPPEVL-----------------LAPATYRPV 616

  Fly   497 AAQAAAQAQAQAQAAAAAMAANRTPPPPPTASTPSSTSSGSPSPDMRPRQYQRFSPYQLPGGQG 560
            ..|:.      ...|.:.:...||.|.|            .|.|::|..:.|...|  ||.|.|
Human   617 TYQSL------YSGAPSHLGIPRTRPAP------------YPLPNIRADRDQGGLP--LPAGLG 660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mid	NP_608927.2	T-box_TBX20-like	186..382	CDD:410319	110/195 (56%)
TBX10	XP_047282835.1	T-box_TBX1_10-like	356..543	CDD:410313	109/194 (56%)