DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mid and Tbx20

DIOPT Version :9

Sequence 1:	NP_001260096.1	Gene:	mid / 33770	FlyBaseID:	FBgn0261963	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	XP_006242782.1	Gene:	Tbx20 / 315497	RGDID:	1309396	Length:	446	Species:	Rattus norvegicus

Alignment Length:	498	Identity:	199/498 - (39%)
Similarity:	270/498 - (54%)	Gaps:	116/498 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 TTTASKSAAGSATDFSIAAIMAREDASSRESSIRSASPISVEDEVDVDVVDCSDAEEPPTKARRL 91
            |.:.....:..|..|||||:|:......:|::..:..|:.       ..|:.|...:|..:...|
  Rat     4 TASPKPQLSSRANAFSIAALMSSGGPKEKEAAENTIKPLE-------QFVEKSSCAQPLGELTSL 61

  Fly    92 NHHQHHQHHQHHHNNNNNNNNNNVAHKSRNSGGAVAQTASAESQLNTSSTSSQGRCSTP--PQSP 154
            :                       ||.....||.             ||.||...|:.|  |.:|
  Rat    62 D-----------------------AHAEFGGGGG-------------SSPSSSSLCTEPLIPTTP 90

  Fly   155 GTEDSEERLTPEPVQKAPKIVGSCNCDDLKPVQCHLETKELWDRFHDLGTEMIITKTGRRMFPTV 219
                               |:.|   :::..:.|.||||||||:||:|||||||||:|||||||:
  Rat    91 -------------------IIPS---EEMAKIACSLETKELWDKFHELGTEMIITKSGRRMFPTI 133

  Fly   220 RVSFSGPLRQIQPADRYAVLMDIIPMDSKRYRYAYHRSAWLVAGKADPAPPARLYAHPDSPFSCE 284
            ||||||    :.|..:|.|||||:|:|:||||||||||:|||||||||..|||||.||||||:.|
  Rat   134 RVSFSG----VDPEAKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKADPPLPARLYVHPDSPFTGE 194

  Fly   285 ALRKQVISFEKVKLTNNEMDKNGQIVLNSMHRYQPRIHLV-RLSHGQSIPSNPKELQDLDHKTYV 348
            .|.||::|||||||||||:|::|.|:|||||:||||:|:: :..|..|:    ..|:..:.:|::
  Rat   195 QLLKQMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIKKKDHTASL----LNLKSEEFRTFI 255

  Fly   349 FPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDSSRLTDFDRDPMEALLLEQQ-LRSPLRLFPDP 412
            |||||||||||||||||||||||||||||||||||||||.:|:.:|:|:.:.. .|||:|.:.:.
  Rat   256 FPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDSSRLTDIERESVESLIQKHSYARSPIRTYGEE 320

  Fly   413 LMQQFAAQGDPSSMALFEKAR-----------------QHLQ-------------------MFGG 441
            .:....:|..|:..:.|..:.                 ||.|                   :.|.
  Rat   321 DVLGEESQTTPNRGSAFTTSDNLSLSSWVSSSSSFPGFQHPQPLTALGTSTASIATPIPHPIQGS 385

  Fly   442 NSPYAQLMMPQMYQAAAAA---AGPPPPPPGLGAFHMFQQQWP 481
            ..||::|.||....|.|::   :||..|...:..:|.:.||.|
  Rat   386 LPPYSRLGMPLTPSAIASSMQGSGPTFPSFHMPRYHHYFQQGP 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mid	NP_001260096.1	TBOX	185..384	CDD:238106	138/199 (69%)
Tbx20	XP_006242782.1	TBOX	99..291	CDD:238106	138/199 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335220
Domainoid	1	1.000	286	1.000	Domainoid score	I1535
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H135956
Inparanoid	1	1.050	321	1.000	Inparanoid score	I2428
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004466
OrthoInspector	1	1.000	-	-		oto95654
orthoMCL	1	0.900	-	-		OOG6_107249
Panther	1	1.100	-	-	LDO	PTHR11267
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2653
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.790