Protein Alignment mid and Tbx5

DIOPT Version :9

• Sequence 1: NP_001260096.1
• Gene: mid / 33770
• FlyBaseID: FBgn0261963
• Length: 580
• Species: Drosophila melanogaster
• Sequence 2: NP_001009964.1
• Gene: Tbx5 / 304514
• RGDID: 1305702
• Length: 517
• Species: Rattus norvegicus
• Alignment Length: 498
• Identity: 153/498 - (30%)
• Similarity: 223/498 - (44%)
• Gaps: 104/498 - (20%)

  Fly   121 NSGGAVAQTA----SAESQLNTSSTSSQGRCSTPPQSPGTEDSEERLTPEPVQKAPKIVGSCNCD 181
            :.|..:|:|.    |.:...::...|:.|..|..|.||....:::
  Rat     5 DEGFGLARTPLEPDSKDRSCDSKPESALGAPSKSPSSPQAAFTQQ-------------------- 49

  Fly   182 DLKPVQCHLETKELWDRFHDLGTEMIITKTGRRMFPTVRVSFSGPLRQIQPADRYAVLMDIIPMD 246
            .::.::..|..:|||.:||::||||||||.||:|||:.:|..:|    :.|..:|.:||||:|.|
  Rat    50 GMEGIKVFLHERELWLKFHEVGTEMIITKAGRQMFPSYKVKVTG----LNPKTKYILLMDIVPAD 110

  Fly   247 SKRYRYAYHRSAWLVAGKADPAPPARLYAHPDSPFSCEALRKQVISFEKVKLTNNEMDKNGQIVL 311
            ..||::|.::  |.|.|||:||.|.|||.|||||.:.....:|::||:|:|||||.:|..|.|:|
  Rat   111 DHRYKFADNK--WSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIIL 173

  Fly   312 NSMHRYQPRIHLVRLSHGQSIPSNPKELQDLDHKTYVFPETVFTAVTAYQNQLITKLKIDSNPFA 376
            ||||:||||:|:|:........|     ::....|:|||||.|.|||:|||..||:|||::||||
  Rat   174 NSMHKYQPRLHIVKADENNGFGS-----KNTAFCTHVFPETAFIAVTSYQNHKITQLKIENNPFA 233

  Fly   377 KGFRDSSRLTDFDRDPMEALLLEQQLRSPLRLFPDPLMQQFAAQGDPSSMALFEKARQHLQMFGG 441
            ||||.|        |.:|...:.:.......:.|...::...|...|     |....:.|.....
  Rat   234 KGFRGS--------DDLELHRMSRMRSKEYPVVPRSTVRHKVANHSP-----FSSETRALSTSSN 285

  Fly   442 NSPYAQLMMPQMYQAAAAAAGP-----PPPPP-GLGAFHM-----------------------FQ 477
                    :...||.....:||     |||.| .|...|.                       :.
  Rat   286 --------LGSQYQCENGVSGPSQDLLPPPNPYPLAQEHSQIYHCTKRKDEECSSTEHPYKKPYM 342

  Fly   478 QQWPQLTAGFLASA-NQQAAAAQAAAQAQAQAQAAAAAMAANRTPPPPPTASTPSSTSSGSPS-- 539
            :..|.....|..|. .||...:.:.....||.|   |.|.|:..||..|..|....:.:..||
  Rat   343 ETSPSEEDTFYRSGYPQQQGLSTSYRTESAQRQ---ACMYASSAPPSEPVPSLEDISCNTWPSMP 404

  Fly   540 -------PDMRPRQ---YQRFSPYQLPGGQGPPSSAA---GSP 569
                   ..::|..   ||.||.:...|...|..:..   |||
  Rat   405 SYSSCTVTTVQPMDRLPYQHFSAHFTSGPLVPRLAGMANHGSP 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mid	NP_001260096.1	TBOX	185..384	CDD:238106	99/198 (50%)
Tbx5	NP_001009964.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..46		10/40 (25%)
		TBOX	53..241	CDD:238106	99/206 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	270..313		11/55 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	331..369		5/37 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335226
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740