DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mid and tbx5a

DIOPT Version :9

Sequence 1:	NP_001260096.1	Gene:	mid / 33770	FlyBaseID:	FBgn0261963	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_001300611.1	Gene:	tbx5a / 30071	ZFINID:	ZDB-GENE-991124-7	Length:	492	Species:	Danio rerio

Alignment Length:	498	Identity:	157/498 - (31%)
Similarity:	230/498 - (46%)	Gaps:	101/498 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 ASAESQLNTSSTSSQGRCSTPP--QSPGTEDSEERLTPEPVQKAPKIVGSCNCDDLKPVQCHLET 192
            |.:|......::.|.   |.|.  |:.|..|.:.    ..|.|:|....:.....::.::.:|..
Zfish     2 ADSEDTFRLQNSPSD---SEPKDLQNEGKSDKQN----AAVSKSPSSQTTYIQQGMEGIKVYLHE 59

  Fly   193 KELWDRFHDLGTEMIITKTGRRMFPTVRVSFSGPLRQIQPADRYAVLMDIIPMDSKRYRYAYHRS 257
            :|||.:||::||||||||.||||||:.:|..:|    :.|..:|.:|||::|.|..||::|.::
Zfish    60 RELWTKFHEVGTEMIITKAGRRMFPSFKVKVTG----LNPKTKYILLMDVVPADDHRYKFADNK- 119

  Fly   258 AWLVAGKADPAPPARLYAHPDSPFSCEALRKQVISFEKVKLTNNEMDKNGQIVLNSMHRYQPRIH 322
             |.|.|||:||.|.|||.|||||.:.....:|::||:|:|||||.:|..|.|:|||||:||||||
Zfish   120 -WSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRIH 183

  Fly   323 LVRLSHGQSIPSNPKELQDLDHKTYVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDS----- 382
            :|:........|     ::....|:|||||.|.|||:|||..||:|||::||||||||.|
Zfish   184 IVKADENNGFGS-----KNTAFCTHVFPETAFIAVTSYQNHKITQLKIENNPFAKGFRGSDDMEL 243

  Fly   383 ---SRLTDFDRDP-MEALLLEQQLRSPLRLFPDPLMQQFAAQGDPSSMALFEKARQHLQMFGGNS 443
               ||:......| :....:.|::.|....|... :|..:|.|..||....|         .|.|
Zfish   244 HRMSRMQSTKEYPVVPRSTVRQRVGSSQSPFSGD-VQGLSASGAISSQYSCE---------NGVS 298

  Fly   444 PYAQLMMPQMYQAAAAAAGPPPPPPGLGAFHMFQQQW--------PQLTAG-------FLASAN- 492
            ..:|.::||.                 .::|...|.:        .:..||       ::.|::
Zfish   299 STSQDLLPQS-----------------SSYHEHTQDYHCIKRKVEDECPAGEHPYKKPYVESSSS 346

  Fly   493 -----------QQAAAAQAAAQAQAQAQAAAAAMAANRTPPPPPTASTPSSTSSGSPS---PDMR 543
                       .|:......|..:.::....|.|.|:...||.|..|....:..|.|.   |.|.
Zfish   347 EDDHYYRPLSYSQSLGLSGGAPYRPESSQRQACMYASAPQPPEPVPSLEDISWPGVPPYSVPQME 411

  Fly   544 PRQYQ-----RFSPYQLPGGQG----------PPSSAAGSPPA 571
            ...||     .|:..|:|...|          .||....||.|
Zfish   412 RLPYQHHFSAHFASRQMPEAHGMYASSVSHQCSPSGGIQSPSA 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mid	NP_001260096.1	TBOX	185..384	CDD:238106	100/206 (49%)
tbx5a	NP_001300611.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43		11/47 (23%)
		TBOX	52..240	CDD:238106	100/198 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	331..352		3/20 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574510
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740