DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mid and TBX21

DIOPT Version :9

Sequence 1:	NP_001260096.1	Gene:	mid / 33770	FlyBaseID:	FBgn0261963	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_037483.1	Gene:	TBX21 / 30009	HGNCID:	11599	Length:	535	Species:	Homo sapiens

Alignment Length:	541	Identity:	152/541 - (28%)
Similarity:	213/541 - (39%)	Gaps:	156/541 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 SSQGRC-STPPQ------SPGTEDSEER--------------LTPEPVQK---------APKIVG 176
            |.:||. ...||      .||.:|::||              |.|.|..:         .|:..|
Human    21 SDEGRAPGADPQHRYFYPEPGAQDADERRGGGSLGSPYPGGALVPAPPSRFLGAYAYPPRPQAAG 85

  Fly   177 ----------SCNCDDLKP--------------------------------VQCHLETKELWDRF 199
                      ..:.:..:|                                ::..|....||.:|
Human    86 FPGAGESFPPPADAEGYQPGEGYAAPDPRAGLYPGPREDYALPAGLEVSGKLRVALNNHLLWSKF 150

  Fly   200 HDLGTEMIITKTGRRMFPTVRVSFSGPLRQIQPADRYAVLMDIIPMDSKRYRYAYHRSAWLVAGK 264
            :...|||||||.||||||.:..:.:|    ::|...|.:.:|::.:|...:|  |....|:..||
Human   151 NQHQTEMIITKQGRRMFPFLSFTVAG----LEPTSHYRMFVDVVLVDQHHWR--YQSGKWVQCGK 209

  Fly   265 ADPAPPA-RLYAHPDSPFSCEALRKQVISFEKVKLTNNEMDKNG---QIVLNSMHRYQPRIHLVR 325
            |:.:.|. |||.|||||.:.....:|.:||.|:|||||:...|.   .|||.|:|:||||:|:|.
Human   210 AEGSMPGNRLYVHPDSPNTGAHWMRQEVSFGKLKLTNNKGASNNVTQMIVLQSLHKYQPRLHIVE 274

  Fly   326 LSHGQSIPSNPKELQDLDH-KTYVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDS--SRLTD 387
            ::.|:     |:...:..: ..:.|.||.|.|||||||..||:||||:||||||||::  |..|.
Human   275 VNDGE-----PEAACNASNTHIFTFQETQFIAVTAYQNAEITQLKIDNNPFAKGFRENFESMYTS 334

  Fly   388 FDRD-PME-------------ALLLEQQLRSPLRLFPD---------PLMQQFAAQGDPSSMALF 429
            .|.. |..             :.||..|...|.|.:||         |......|..|.|..|.|
Human   335 VDTSIPSPPGPNCQFLGGDHYSPLLPNQYPVPSRFYPDLPGQAKDVVPQAYWLGAPRDHSYEAEF 399

  Fly   430 EKARQHLQMFGGNSPYAQLMMPQMYQAAAAAAG---PPPPPPGLGAFHMFQQQWPQLTAGFLASA 491
             :|......|..::|...:...:..:..|..||   .|..||.:|....|:   |..|.
Human   400 -RAVSMKPAFLPSAPGPTMSYYRGQEVLAPGAGWPVAPQYPPKMGPASWFR---PMRTL------ 454

  Fly   492 NQQAAAAQAAAQAQAQAQAAAAAMAANRTPPP--PPTAST------PSSTSSGSPSPDMRPRQYQ 548
                            ........:..|.|..  ||...|      |.|:.||....|.:.|
Human   455 ----------------PMEPGPGGSEGRGPEDQGPPLVWTEIAPIRPESSDSGLGEGDSKRR--- 500

  Fly   549 RFSPYQLPGGQGPPSSAAGSP 569
            |.|||.   ..|..||.||:|
Human   501 RVSPYP---SSGDSSSPAGAP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mid	NP_001260096.1	TBOX	185..384	CDD:238106	86/237 (36%)
TBX21	NP_037483.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..62		10/40 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	83..109		2/25 (8%)
		T-box_TBX21	136..326	CDD:410329	84/200 (42%)
		T-box_assoc	<394..525	CDD:406561	37/157 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..535		23/101 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141539
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740