DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mid and MGA

DIOPT Version :9

Sequence 1:	NP_001260096.1	Gene:	mid / 33770	FlyBaseID:	FBgn0261963	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	XP_005254300.1	Gene:	MGA / 23269	HGNCID:	14010	Length:	3115	Species:	Homo sapiens

Alignment Length:	225	Identity:	93/225 - (41%)
Similarity:	130/225 - (57%)	Gaps:	11/225 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 PVQKAPKIVGSCNCDDLKPVQCHLETKELWDRFHDLGTEMIITKTGRRMFPTVRVSFSGPLRQIQ 231
            ||:...||....:| .:..:...|:...:|:.|:...||||:||.||||||..|...:|    :.
Human    57 PVKSKGKICLPADC-TVGGITVTLDNNSMWNEFYHRSTEMILTKQGRRMFPYCRYWITG----LD 116

  Fly   232 PADRYAVLMDIIPMDSKRYRYAYHRSAWLVAGKADPAPPARLYAHPDSPFSCEALRKQVISFEKV 296
            ...:|.::|||.|:|:  :||.::...|..:|||:|....|::.||:||.:......|.:||.|:
Human   117 SNLKYILVMDISPVDN--HRYKWNGRWWEPSGKAEPHVLGRVFIHPESPSTGHYWMHQPVSFYKL 179

  Fly   297 KLTNNEMDKNGQIVLNSMHRYQPRIHLVRLSHGQSIPSNPKELQDLDHKTYVFPETVFTAVTAYQ 361
            |||||.:|:.|.|:|:|||||.||:|||.......:    .:|......|:.||:|.|.||||||
Human   180 KLTNNTLDQEGHIILHSMHRYLPRLHLVPAEKAVEV----IQLNGPGVHTFTFPQTEFFAVTAYQ 240

  Fly   362 NQLITKLKIDSNPFAKGFRDSSRLTDFDRD 391
            |..||:||||.|||||||||........||
Human   241 NIQITQLKIDYNPFAKGFRDDGLNNKPQRD 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mid	NP_001260096.1	TBOX	185..384	CDD:238106	86/198 (43%)
MGA	XP_005254300.1	TBOX	74..264	CDD:238106	86/199 (43%)
		DUF4801	1041..1087	CDD:292677
		HLH	2475..2525	CDD:278439
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141543
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1201455at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750