DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mid and Tbx5

DIOPT Version :9

Sequence 1:	NP_001260096.1	Gene:	mid / 33770	FlyBaseID:	FBgn0261963	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	XP_006530342.1	Gene:	Tbx5 / 21388	MGIID:	102541	Length:	537	Species:	Mus musculus

Alignment Length:	501	Identity:	161/501 - (32%)
Similarity:	225/501 - (44%)	Gaps:	105/501 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 ASAESQLNTSSTSSQG-RCSTPPQSPGTEDSEERLTPEPVQKAPKIVGSC-----NCDDLKPVQC 188
            |.|:..|.|.:.:.:| ..:..|..|.::|......||....||....|.     ....::.::.
Mouse    11 ARAQEPLRTMADTDEGFGLARTPLEPDSKDRSCDSKPESALGAPSKSPSSPQAAFTQQGMEGIKV 75

  Fly   189 HLETKELWDRFHDLGTEMIITKTGRRMFPTVRVSFSGPLRQIQPADRYAVLMDIIPMDSKRYRYA 253
            .|..:|||.:||::||||||||.||||||:.:|..:|    :.|..:|.:||||:|.|..||::|
Mouse    76 FLHERELWLKFHEVGTEMIITKAGRRMFPSYKVKVTG----LNPKTKYILLMDIVPADDHRYKFA 136

  Fly   254 YHRSAWLVAGKADPAPPARLYAHPDSPFSCEALRKQVISFEKVKLTNNEMDKNGQIVLNSMHRYQ 318
            .::  |.|.|||:||.|.|||.|||||.:.....:|::||:|:|||||.:|..|.|:|||||:||
Mouse   137 DNK--WSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQ 199

  Fly   319 PRIHLVRLSHGQSIPSNPKELQDLDHKTYVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDSS 383
            ||:|:|:........|     ::....|:|||||.|.|||:|||..||:|||::||||||||.|
Mouse   200 PRLHIVKADENNGFGS-----KNTAFCTHVFPETAFIAVTSYQNHKITQLKIENNPFAKGFRGS- 258

  Fly   384 RLTDFDRDPMEALLLEQQLRSPLRLFPDPLMQQFAAQGDPSSMALFEKARQHLQMFGGNSPYA-- 446
                   |.:|   |.:..|...:.:|..          |.|....:....|       ||::
Mouse   259 -------DDLE---LHRMSRMQSKEYPVV----------PRSTVRHKVTSNH-------SPFSSE 296

  Fly   447 ------QLMMPQMYQAAAAAAGP-----PPPPP-GLGAFHM-----------------------F 476
                  ...:...||.....:||     |||.| .|...|.                       :
Mouse   297 TRALSTSSNLGSQYQCENGVSGPSQDLLPPPNPYPLAQEHSQIYHCTKRKDEECSSTEHPYKKPY 361

  Fly   477 QQQWPQLTAGFLASA-NQQAAAAQAAAQAQAQAQAAAAAMAANRTPPPPPTASTPSSTSSGSPS- 539
            .:..|.....|..|. .||...:.:.....||.|   |.|.|:..||..|..|....:.:..||
Mouse   362 METSPSEEDTFYRSGYPQQQGLSTSYRTESAQRQ---ACMYASSAPPSEPVPSLEDISCNTWPSM 423

  Fly   540 -------------PDMRPRQYQRFSPYQLPGGQGPPSSAA---GSP 569
                         .|..|  ||.||.:...|...|..:..   |||
Mouse   424 PSYSSCTVTTVQPMDRLP--YQHFSAHFTSGPLVPRLAGMANHGSP 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mid	NP_001260096.1	TBOX	185..384	CDD:238106	100/198 (51%)
Tbx5	XP_006530342.1	TBOX	72..260	CDD:238106	100/206 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831489
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740