Protein Alignment mid and Tbx2

DIOPT Version :9

• Sequence 1: NP_001260096.1
• Gene: mid / 33770
• FlyBaseID: FBgn0261963
• Length: 580
• Species: Drosophila melanogaster
• Sequence 2: NP_033350.2
• Gene: Tbx2 / 21385
• MGIID: 98494
• Length: 711
• Species: Mus musculus
• Alignment Length: 657
• Identity: 196/657 - (29%)
• Similarity: 254/657 - (38%)
• Gaps: 260/657 - (39%)

  Fly   122 SGGAVAQTASAESQLNTSSTSSQGRCSTPPQSPGTE-DSEERLTPE-PVQKAPKIVGSCNCDDLK 184
            :..|.|..|:||:.|:.|:..        |..|... .|.:.|.|| .|:..||:.
Mouse    61 AAAAAAAAAAAEAGLHVSALG--------PHPPAAHLRSLKSLEPEDEVEDDPKVT--------- 108

  Fly   185 PVQCHLETKELWDRFHDLGTEMIITKTGRRMFPTVRVSFSGPLRQIQPADRYAVLMDIIPMDSKR 249
                 ||.|||||:||.|||||:|||:||||||..:|..||    :....:|.:||||:..|..|
Mouse   109 -----LEAKELWDQFHKLGTEMVITKSGRRMFPPFKVRVSG----LDKKAKYILLMDIVAADDCR 164

  Fly   250 YRYAYHRSAWLVAGKADPAPPARLYAHPDSPFSCEALRKQVISFEKVKLTNNEMDKNGQIVLNSM 314
            |:  :|.|.|:|||||||..|.|:|.|||||.:.|....:.::|.|:|||||..||:|..:||||
Mouse   165 YK--FHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFTILNSM 227

  Fly   315 HRYQPRIHLVRLSHGQSIPSNPKELQDLDHKTYVFPETVFTAVTAYQNQLITKLKIDSNPFAKGF 379
            |:||||.|:||.:....:|.:       ..:|||||||.|.|||||||..||:||||:|||||||
Mouse   228 HKYQPRFHIVRANDILKLPYS-------TFRTYVFPETDFIAVTAYQNDKITQLKIDNNPFAKGF 285

  Fly   380 RDS--------SRLT-------------------------------------------------- 386
            ||:        .:||
Mouse   286 RDTGNGRREKRKQLTLPTLRLYEEHCKPERDGAESDASSCDPPPAREPPPSPSAAPSPLRLHRAR 350

  Fly   387 --------DFD--------------------RDPMEALLLE----QQLRSPLRLFPDPLMQQFAA 419
                    |.|                    ||...|.|.|    ::.|||.|...:|.    ..
Mouse   351 AEEKPGAADSDPEPERTGEERSAAPLGRSPSRDASPARLTEPERSRERRSPERCSKEPT----EG 411

  Fly   420 QGD-PSSMALFEKAR---------------------------------------------QHL-- 436
            .|| |.|:...||.|                                             .||
Mouse   412 GGDGPFSLRSLEKERPEARRKDEGRKDVGEGKEPSLAPLVVQTDSASPLGAGHLPGLAFSSHLHG 476

  Fly   437 -QMFG-----------------GNSPYAQLMMPQMYQAAAAAAGP-----PPPPPGLGA------ 472
             |.||                 |...::.:.|..:..:.|..:|.     |....||.|
Mouse   477 QQFFGPLGAGQPLFLHPGQFAMGPGAFSAMGMGHLLASVAGGSGSSGGAGPGTAAGLDAGGLGPA 541

  Fly   473 -----------FHMFQ-----QQWPQLTAG--------FLASANQQAAAAQAAAQAQAQAQAAAA 513
                       ||:.|     |..|..|.|        ::|:|   ||||.|.....|.|.||||
Mouse   542 ASAASTAAPFPFHLSQHMLASQGIPMPTFGGLFPYPYTYMAAA---AAAASALPATSAAAAAAAA 603

  Fly   514 AMAANRTPPPPPTASTPSSTSSGSPSPDMRPRQYQRFSPYQLPGGQGPPSS-------AAGSPPA 571
            |.:.:|:|            ..||..|.:      ||||||:|....|.:|       |.||...
Mouse   604 AGSLSRSP------------FLGSARPRL------RFSPYQIPVTIPPSTSLLTTGLAAEGSKGG 650

  Fly   572 VNASRSP 578
            .:...||
Mouse   651 NSREPSP 657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mid	NP_001260096.1	TBOX	185..384	CDD:238106	106/206 (51%)
Tbx2	NP_033350.2	TBOX	104..289	CDD:238106	108/211 (51%)
		TBX	305..382	CDD:204975	2/76 (3%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	313..449		19/139 (14%)
		Repression domain 1 (RD1). /evidence=ECO:0000250	518..602		22/86 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	640..687		5/18 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831477
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740