Protein Alignment mid and TBR1

DIOPT Version :9

• Sequence 1: NP_001260096.1
• Gene: mid / 33770
• FlyBaseID: FBgn0261963
• Length: 580
• Species: Drosophila melanogaster
• Sequence 2: NP_006584.1
• Gene: TBR1 / 10716
• HGNCID: 11590
• Length: 682
• Species: Homo sapiens
• Alignment Length: 574
• Identity: 179/574 - (31%)
• Similarity: 225/574 - (39%)
• Gaps: 142/574 - (24%)

  Fly    98 QHHQHHHNNNNNNNNNNVAHKSRNSGGAVAQTASAESQLNTSSTSSQGRCSTP-PQSPGTEDSEE 161
            ||...|...:..:.:..:||....:.||.      .|.|:.||.........| ||..|
Human   129 QHGPAHPAFSIGSPSRYMAHHPVITNGAY------NSLLSNSSPQGYPTAGYPYPQQYG------ 181

  Fly   162 RLTPEPVQKAPKIVGSCNCDDLKP--VQCHLETKELWDRFHDLGTEMIITKTGRRMFPTVRVSFS 224
                ...|.||....|.....|.|  .|.:|..:.||.:||...|||||||.||||||.:..:.|
Human   182 ----HSYQGAPFYQFSSTQPGLVPGKAQVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNIS 242

  Fly   225 GPLRQIQPADRYAVLMDIIPMDSKRYRYAYHRSAWLVAGKADP-APPARLYAHPDSPFSCEALRK 288
            |    :.|...|.:.:|:|..|...:|  :....|:..||||. ....|:|.|||||.:.....:
Human   243 G----LDPTAHYNIFVDVILADPNHWR--FQGGKWVPCGKADTNVQGNRVYMHPDSPNTGAHWMR 301

  Fly   289 QVISFEKVKLTNNE--MDKNGQ-IVLNSMHRYQPRIHLVRLSH-GQSIPSNPKELQDLDHKTYVF 349
            |.|||.|:|||||:  .:.||| :||.|:|:||||:|:|.::. |....|.|..:|     |:.|
Human   302 QEISFGKLKLTNNKGASNNNGQMVVLQSLHKYQPRLHVVEVNEDGTEDTSQPGRVQ-----TFTF 361

  Fly   350 PETVFTAVTAYQNQLITKLKIDSNPFAKGFRDS----------SRLTDFDRD------------P 392
            |||.|.|||||||..||:||||.|||||||||:          .|||....|            .
Human   362 PETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDTIYTGCDMDRLTPSPNDSPRSQIVPGARYA 426

  Fly   393 MEALLLEQQLRS---PLRLFP---------------------DPLMQQFAAQGDPSSMALF-EKA 432
            |....|:.|..|   ..|..|                     .|  ||....|.||....| ..|
Human   427 MAGSFLQDQFVSNYAKARFHPGAGAGPGPGTDRSVPHTNGLLSP--QQAEDPGAPSPQRWFVTPA 489

  Fly   433 RQHLQM----------FGGNS----PYAQLMMPQMYQAAAAAAGPP----PPPPGLGAFHMFQQQ 479
            ...|..          |.||:    .||...:..:...||...|.|    ..|.|.||     :.
Human   490 NNRLDFAASAYDTATDFAGNAATLLSYAAAGVKALPLQAAGCTGRPLGYYADPSGWGA-----RS 549

  Fly   480 WPQL----TAGFLASANQQAAAAQAAAQAQAQAQAAAAAMAANRTPPPPPTA------------- 527
            .||.    :...|......||||...|.|.......|..:||.|:|.||..|
Human   550 PPQYCGTKSGSVLPCWPNSAAAAARMAGANPYLGEEAEGLAAERSPLPPGAAEDAKPKDLSDSSW 614

  Fly   528 -STPSSTSS--GSPSPDMRPRQYQRFSPYQLPGGQGPPSSAAGSPPAVNASRSP 578
             .||||..|  .|.|......:.:|.||...|               |:.|.||
Human   615 IETPSSIKSIDSSDSGIYEQAKRRRISPADTP---------------VSESSSP 653

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mid	NP_001260096.1	TBOX	185..384	CDD:238106	95/215 (44%)
TBR1	NP_006584.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	43..83
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	108..127
		T-box_TBR1	203..393	CDD:410330	92/200 (46%)
		T-box_assoc	418..680	CDD:406561	60/258 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	447..483		7/37 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	588..658		22/81 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141541
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740