Protein Alignment H15 and TBX4

DIOPT Version :10

• Sequence 1: NP_608926.2
• Gene: H15 / 33769
• FlyBaseID: FBgn0016660
• Length: 660
• Species: Drosophila melanogaster
• Sequence 2: XP_011523792.1
• Gene: TBX4 / 9496
• HGNCID: 11603
• Length: 609
• Species: Homo sapiens
• Alignment Length: 565
• Identity: 169/565 - (29%)
• Similarity: 241/565 - (42%)
• Gaps: 165/565 - (29%)

  Fly   215 SKSSSQRGRSAAAVGAAATPSPPPPPP--------------SQSPEELERLSP---EESPAQQPT 262
            |||.....|....:|....|...|..|              |:|.|......|   |.|.|..|.
Human    30 SKSKPGMRRPLNKMGERPEPGDAPGGPGESGKKEMLQDKGLSESEEAFRAPGPALGEASAANAPE 94

  Fly   263 P--------------------KIVGSCNCDD-LTPVQCHLETKELWDKFHELGTEMIITKSGRRM 306
            |                    .:|.:...:. :..::..|..||||.||||.||||||||:||||
Human    95 PALAAPGLSGAALGSPPGPGADVVAAAAAEQTIENIKVGLHEKELWKKFHEAGTEMIITKAGRRM 159

  Fly   307 FPTVRVSFSGPLRQIQPADRYAVLLDVVPLDSRRYRYAYHRSSWLVAGKADPPPPSRIYAHPDCP 371
            ||:.:|..:|    :.|..:|.:|:|:||.|..||::..::  |:|||||:|..|.|:|.|||.|
Human   160 FPSYKVKVTG----MNPKTKYILLIDIVPADDHRYKFCDNK--WMVAGKAEPAMPGRLYVHPDSP 218

  Fly   372 LSPEALRKQVVSFEKVKLTNNEMDKSGQVVLNSMHRYQPRIHLVRLSHGQSIPGSPKELQDMDHK 436
            .:.....:|:|||:|:|||||.:|..|.::|||||:||||:|:|:.....:. ||    ::....
Human   219 ATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNAF-GS----KNTAFC 278

  Fly   437 TFVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDS-------SRLSDFDRDPMDAFFFDQHMR 494
            |.|||||.|.:||:|||..||:|||::||||||||.|       :||...:...:......|.:.
Human   279 THVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDSDLRVARLQSKEYPVISKSIMRQRLI 343

  Fly   495 TAPLRFFPD--PLM----------------SQLT----------PQEADAASMALLEKAR----Q 527
            :..|...||  ||:                |||.          |.:.|::......|.|    :
Human   344 SPQLSATPDVGPLLGTHQALQHYQHENGAHSQLAEPQDLPLSTFPTQRDSSLFYHCLKRRADGTR 408

  Fly   528 HLQMFGRSPYTEMLLP------HLYQRSAAPPP-------PPPAPHLSAFQLGMWQQQWPQLTAG 579
            ||.:..:..|.|  .|      |.::   :|||       |.....::..:..|:....|:: ||
Human   409 HLDLPCKRSYLE--APSSVGEDHYFR---SPPPYDQQMLSPSYCSEVTPREACMYSGSGPEI-AG 467

  Fly   580 FLASANQQAALALAAAGANRTPPPSM------AVAP-----------------PA--------PA 613
                          .:|.:..|||.:      :|:|                 |.        |.
Human   468 --------------VSGVDDLPPPPLSCNMWTSVSPYTSYSVQTMETVPYQPFPTHFTATTMMPR 518

  Fly   614 TPTSSCGSASPDLRARPQLNHYPQRFSPY-QVPQHQA---SPPAS 654
            .||.|..|:.|...|         .||.| |:.|.|.   .|.||
Human   519 LPTLSAQSSQPPGNA---------HFSVYNQLSQSQVRERGPSAS 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
H15	NP_608926.2	T-box_TBX20-like	277..473	CDD:410319	98/195 (50%)
TBX4	XP_011523792.1	T-box_TBX4_5-like	130..314	CDD:410315	97/194 (50%)