Protein Alignment H15 and Tbx18

DIOPT Version :9

• Sequence 1: NP_608926.2
• Gene: H15 / 33769
• FlyBaseID: FBgn0016660
• Length: 660
• Species: Drosophila melanogaster
• Sequence 2: NP_076303.3
• Gene: Tbx18 / 76365
• MGIID: 1923615
• Length: 613
• Species: Mus musculus
• Alignment Length: 568
• Identity: 200/568 - (35%)
• Similarity: 272/568 - (47%)
• Gaps: 127/568 - (22%)

  Fly   153 ALQAQQQARQALRVAQQQQQQQQQQRQQTHHHATTGKQQRQHHNHHSSNTNNSSNSGNSNTNSKS 217
            :|:|...:.:||..|::|||.|:::|:.....|....:..           ..|.||       .
Mouse    14 SLKAHAFSVEALIGAEKQQQLQKKRRKLATEEAAGAVEDA-----------GCSRSG-------G 60

  Fly   218 SSQRGRSAAAVGAAATPSPPPPP-----PSQSPEELER----------------------LSPEE 255
            :.:.|.|.|...|||   |||..     |::|..:.||                      .||..
Mouse    61 AGEHGCSEADEEAAA---PPPAAGAASGPARSCADAERSCGSRGAAGSCEDGFLQGASPLASPGG 122

  Fly   256 SPAQQPTPKIV--GSCNCDDLTPV------QCHLETKELWDKFHELGTEMIITKSGRRMFPTVRV 312
            ||...|.|.:.  |       ||:      :..|:..|||.:|||:||||||||:||||||.:||
Mouse   123 SPKGSPVPGLARPG-------TPLPAPQAPRVDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRV 180

  Fly   313 SFSGPLRQIQPADRYAVLLDVVPLDSRRYRYAYHRSSWLVAGKADPPPPSRIYAHPDCPLSPEAL 377
            ..||    :.|..:|.:.:|:||:|::||||.||.|.|:|||.||.|.|.|:|.|||.|.|.|..
Mouse   181 KISG----LDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADSPVPPRVYIHPDSPASGETW 241

  Fly   378 RKQVVSFEKVKLTNNEMDKSGQVVLNSMHRYQPRIHLVRLSHGQSIPGSP-KELQDMDH-KTFVF 440
            .:||:||:|:||||||:|..|.::|:|||:||||:|::|...|..:  || |.:...:. |.|.|
Mouse   242 MRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDCGDDL--SPIKPVPSGEGVKAFSF 304

  Fly   441 PETVFTAVTAYQNQLITKLKIDSNPFAKGFRDSSRLSDFDRDPMDAF-----FFDQHMRTAPLRF 500
            ||||||.|||||||.||:||||.||||||||||.|    :|..::|.     |:...:||.....
Mouse   305 PETVFTTVTAYQNQQITRLKIDRNPFAKGFRDSGR----NRMGLEALVESYAFWRPSLRTLTFED 365

  Fly   501 FPDPLMSQLTPQEADAASMALLEKARQHLQMFGRSPYTEMLLPHLYQRSAAPPPPPPAPHLSAFQ 565
            .|.      .|::.:.:|.|||:.....:      |.|.   |||...|:...|        ||.
Mouse   366 IPG------IPKQGNTSSSALLQGTGNAV------PATH---PHLLSGSSCSSP--------AFH 407

  Fly   566 LGMWQQQWPQLT-AGFLASANQQAAL-----ALAAAGANRTPPPSMAVAPPAPATPT-------- 616
            ||....|...|. |.:.|.|....||     :||...:..|...|...||  |.||:
Mouse   408 LGPNTSQLCSLAPADYSACARSGLALNRYSTSLAETYSRLTNQSSETFAP--PRTPSYVSVSSNP 470

  Fly   617 ---SSCGSASPDLRARPQ--LNHYPQRFSP---YQVPQHQASPPASNR 656
               .|.|....|..:.||  |:......||   |.:|....:..|:|:
Mouse   471 SVNMSMGGTDGDTFSCPQTSLSMQISGMSPQLQYIMPSPSGNAFAANQ 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
H15	NP_608926.2	TBOX	276..475	CDD:238106	114/206 (55%)
Tbx18	NP_076303.3	Engrailed homology 1 repressor. /evidence=ECO:0000305|PubMed:17584735	18..28		2/9 (22%)
		Nuclear localization signal. /evidence=ECO:0000305|PubMed:17584735	36..40		0/3 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	37..94		16/77 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	114..145		9/37 (24%)
		TBOX	145..340	CDD:238106	114/204 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	255	1.000	Inparanoid score	I3156
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.860