Protein Alignment H15 and TBX3

DIOPT Version :9

• Sequence 1: NP_608926.2
• Gene: H15 / 33769
• FlyBaseID: FBgn0016660
• Length: 660
• Species: Drosophila melanogaster
• Sequence 2: NP_057653.3
• Gene: TBX3 / 6926
• HGNCID: 11602
• Length: 743
• Species: Homo sapiens
• Alignment Length: 609
• Identity: 173/609 - (28%)
• Similarity: 231/609 - (37%)
• Gaps: 222/609 - (36%)

  Fly   228 VGAAATPSP-PPPPPSQSPEELERLSPEESPAQQPTPKIVGSCNCDDLTPVQCHLETKELWDKFH 291
            ||||.|..| ....|......|:.:.|||.....|                :.|||.|||||:||
Human    69 VGAAETGIPFSSLGPQAHLRPLKTMEPEEEVEDDP----------------KVHLEAKELWDQFH 117

  Fly   292 ELGTEMIITKSGRRMFPTVRVSFSGPLRQIQPADRYAVLLDVVPLDSRRYRYAYHRSSWLVAGKA 356
            :.||||:||||||||||..:|..||    :....:|.:|:|::..|..||:  :|.|.|:|||||
Human   118 KRGTEMVITKSGRRMFPPFKVRCSG----LDKKAKYILLMDIIAADDCRYK--FHNSRWMVAGKA 176

  Fly   357 DPPPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNEMDKSG--------------------QVV 401
            ||..|.|:|.|||.|.:.|....:||:|.|:|||||..||.|                    |.:
Human   177 DPEMPKRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQTI 241

  Fly   402 LNSMHRYQPRIHLVRLSHGQSIPGSPKELQDMDHKTFVFPETVFTAVTAYQNQLITKLKIDSNPF 466
            |||||:||||.|:||.:....:|.|       ..:|::||||.|.|||||||..||:||||:|||
Human   242 LNSMHKYQPRFHIVRANDILKLPYS-------TFRTYLFPETEFIAVTAYQNDKITQLKIDNNPF 299

  Fly   467 AKGFRD---------------SSRLSDFDRDPMDAFFFDQHMRTAPLRFF---PDPLMS------ 507
            ||||||               |.|:.|......:....:.....|....|   ..|..|
Human   300 AKGFRDTGNGRREKRKQLTLQSMRVFDERHKKENGTSDESSSEQAAFNCFAQASSPAASTVGTSN 364

  Fly   508 --QLTPQEADAASMALLEKARQH----------------------------LQMFG--------- 533
              .|.|.|.::.:.|  |...:|                            ..:|.
Human   365 LKDLCPSEGESDAEA--ESKEEHGPEACDAAKISTTTSEEPCRDKGSPAVKAHLFAAERPRDSGR 427

  Fly   534 ---------------------------RSPYTEMLLPHLYQRSAAPP-----------PPPPAPH 560
                                       |||..|...|...:.:.|.|           ....|.|
Human   428 LDKASPDSRHSPATISSSTRGLGAEERRSPVREGTAPAKVEEARALPGKEAFAPLTVQTDAAAAH 492

  Fly   561 LS-------AFQLGMWQQQW----------------------------PQL---------TAGFL 581
            |:       .|..|:..||:                            |.|         .:|..
Human   493 LAQGPLPGLGFAPGLAGQQFFNGHPLFLHPSQFAMGGAFSSMAAAGMGPLLATVSGASTGVSGLD 557

  Fly   582 ASANQQAALALAAAGANRTPPP-----------SMAVAP-----PAP-----ATPTSSCGSASPD 625
            ::|...||.|...:||:....|           .:|::|     |.|     |...:|..:||..
Human   558 STAMASAAAAQGLSGASAATLPFHLQQHVLASQGLAMSPFGSLFPYPYTYMAAAAAASSAAASSS 622

  Fly   626 LRARPQLN---HYPQ-RFSPYQVP 645
            :...|.||   ..|: |:|||.:|
Human   623 VHRHPFLNLNTMRPRLRYSPYSIP 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
H15	NP_608926.2	TBOX	276..475	CDD:238106	107/233 (46%)
TBX3	NP_057653.3	TBOX	104..307	CDD:238106	106/215 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	301..342		8/40 (20%)
		TBX	323..411	CDD:204975	12/89 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	357..465		12/109 (11%)
		Transcription repression	544..695		25/103 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	688..707

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141520
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740