Protein Alignment H15 and TBX2

DIOPT Version :9

• Sequence 1: NP_608926.2
• Gene: H15 / 33769
• FlyBaseID: FBgn0016660
• Length: 660
• Species: Drosophila melanogaster
• Sequence 2: NP_005985.3
• Gene: TBX2 / 6909
• HGNCID: 11597
• Length: 712
• Species: Homo sapiens
• Alignment Length: 619
• Identity: 186/619 - (30%)
• Similarity: 246/619 - (39%)
• Gaps: 227/619 - (36%)

  Fly   222 GRSAAAVGAAATPSP-------PPPPPSQSPEELERLSPEESPAQQPTPKIVGSCNCDDLTPVQC 279
            |.:|||..|||....       .|.||:.....|:.|.||:.  .:..||:.
Human    59 GAAAAAAAAAAAAEAGLHVSALGPHPPAAHLRSLKSLEPEDE--VEDDPKVT------------- 108

  Fly   280 HLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGPLRQIQPADRYAVLLDVVPLDSRRYRYA 344
             ||.|||||:||:|||||:||||||||||..:|..||    :....:|.:|:|:|..|..||:
Human   109 -LEAKELWDQFHKLGTEMVITKSGRRMFPPFKVRVSG----LDKKAKYILLMDIVAADDCRYK-- 166

  Fly   345 YHRSSWLVAGKADPPPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNEMDKSGQVVLNSMHRYQ 409
            :|.|.|:|||||||..|.|:|.|||.|.:.|....:.|:|.|:|||||..||.|..:|||||:||
Human   167 FHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQ 231

  Fly   410 PRIHLVRLSHGQSIPGSPKELQDMDHKTFVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDSS 474
            ||.|:||.:....:|.|       ..:|:|||||.|.|||||||..||:||||:|||||||||:.
Human   232 PRFHIVRANDILKLPYS-------TFRTYVFPETDFIAVTAYQNDKITQLKIDNNPFAKGFRDTG 289

  Fly   475 RLSDFDRDPM---DAFFFDQHMR----------------------------TAPLRFF------- 501
            ......|..:   ....:::|.:                            .:|||..
Human   290 NGRREKRKQLTLPSLRLYEEHCKPERDGAESDASSCDPPPAREPPTSPGAAPSPLRLHRARAEEK 354

  Fly   502 -----PDPLMSQLTPQEA----------DAASMALL------------EKARQHLQMFGRSPY-- 537
                 .||...:|:.:.|          |:||...|            |:.::..:..|..|:
Human   355 SCAADSDPEPERLSEERAGAPLGRSPAPDSASPTRLTEPERARERRSPERGKEPAESGGDGPFGL 419

  Fly   538 ------------------------TEMLLPHLYQRSAAPPPPPPAPHLS--AFQLGMWQQQW--- 573
                                    .:.|.|.:.|..:|  .|..|.||.  ||...:..||:
Human   420 RSLEKERAEARRKDEGRKEAAEGKEQGLAPLVVQTDSA--SPLGAGHLPGLAFSSHLHGQQFFGP 482

  Fly   574 -------------------------------------------PQLTAGF-------LASANQQA 588
                                                       |...||.       .|||...|
Human   483 LGAGQPLFLHPGQFTMGPGAFSAMGMGHLLASVAGGGNGGGGGPGTAAGLDAGGLGPAASAASTA 547

  Fly   589 A-------------------------------LALAAAGANRTPPPSMAVAPPAPATPTSSCGSA 622
            |                               :|.|||.|:..|..|.|.|..|.|...    |.
Human   548 APFPFHLSQHMLASQGIPMPTFGGLFPYPYTYMAAAAAAASALPATSAAAAAAAAAGSL----SR 608

  Fly   623 SPDL-RARPQLNHYPQRFSPYQVPQHQASPPASN 655
            ||.| .|||:|     ||||||:|  ...||:::
Human   609 SPFLGSARPRL-----RFSPYQIP--VTIPPSTS 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
H15	NP_608926.2	TBOX	276..475	CDD:238106	106/198 (54%)
TBX2	NP_005985.3	T-box_TBX2_3-like	103..287	CDD:410314	106/210 (50%)
		PHA03307	300..>467	CDD:223039	23/168 (14%)
		TBX	305..383	CDD:403708	8/77 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	313..450		15/136 (11%)
		Repression domain 1 (RD1)	518..601		17/82 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	637..687

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141522
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740