Protein Alignment H15 and TBX1

DIOPT Version :10

• Sequence 1: NP_608926.2
• Gene: H15 / 33769
• FlyBaseID: FBgn0016660
• Length: 660
• Species: Drosophila melanogaster
• Sequence 2: XP_016884416.2
• Gene: TBX1 / 6899
• HGNCID: 11592
• Length: 522
• Species: Homo sapiens
• Alignment Length: 519
• Identity: 179/519 - (34%)
• Similarity: 230/519 - (44%)
• Gaps: 172/519 - (33%)

  Fly   224 SAAAVGAAATPSPPPPP------PSQSPEELERLSPE------ESPAQQP---TPKIVGSCNCDD 273
            :|||.||   |.|||||      |:..........||      .:.|:.|   ..|:.|
Human    63 AAAAPGA---PGPPPPPHAYPFAPAAGAATSAAAEPEGPGASCAAAAKAPVKKNAKVAG------ 118

  Fly   274 LTPVQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGPLRQIQPADRYAVLLDVVPLDS 338
               |...||.|.|||:|::||||||:||:|||||||.:|...|    :.|...|.:|:|.||:|.
Human   119 ---VSVQLEMKALWDEFNQLGTEMIVTKAGRRMFPTFQVKLFG----MDPMADYMLLMDFVPVDD 176

  Fly   339 RRYRYAYHRSSWLVAGKADPPPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNEMDKSGQVVLN 403
            :|||||:|.|||||||||||..|.|::.|||.|.......||:|||:|:|||||.:|.:|.::||
Human   177 KRYRYAFHSSSWLVAGKADPATPGRVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHIILN 241

  Fly   404 SMHRYQPRIHLVRLSHGQSIPGSPKE-LQDMDHKTFVFPETVFTAVTAYQNQL------------ 455
            ||||||||.|:|.:.     |....| ..:.:.|||||.||.|||||||||..
Human   242 SMHRYQPRFHVVYVD-----PRKDSEKYAEENFKTFVFEETRFTAVTAYQNHRVRACGEDLSGFN 301

  Fly   456 ------ITKLKIDSNPFAKGFRDSSRLSDFDRDPMDAFFFDQHMRTAPLRFFPDPLMS------- 507
                  ||:|||.||||||||||.        ||.|   :.::.|...|     ||||
Human   302 ASGKAGITQLKIASNPFAKGFRDC--------DPED---WPRNHRPGAL-----PLMSAFARSRN 350

  Fly   508 ------QLTPQEADAASMALLEKARQHLQMFGRSPYTEMLLPHLYQRSAAPPP---PPPAPHLSA 563
                  |.:..|.|||      :||:.                 :||.|..|.   .|..|
Human   351 PVASPTQPSGTEKDAA------EARRE-----------------FQRDAGGPAVLGDPAHP---- 388

  Fly   564 FQLGMWQQQWPQLTAGFLASANQQAALALAAAGANRTPP----PSMAVAPPAPATPTSSCGSASP 624
                      |||.|..|:.:      ...|.||....|    |....:||.|.....:.|::.|
Human   389 ----------PQLLARVLSPS------LPGAGGAGGLVPLPGAPGGRPSPPNPELRLEAPGASEP 437

  Fly   625 DLRARPQLNHYPQRF---------------SPYQVP----------------QHQASPPASNRA 657
                   |:|:|.::               :||.:|                .|..||.|:..|
Human   438 -------LHHHPYKYPAAAYDHYLGAKSRPAPYPLPGLRGHGYHPHAHPHHHHHPVSPAAAAAA 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
H15	NP_608926.2	T-box_TBX20-like	277..473	CDD:410319	112/214 (52%)
TBX1	XP_016884416.2	T-box_TBX1_10-like	118..324	CDD:410313	112/223 (50%)