Protein Alignment H15 and tbx2

DIOPT Version :10

• Sequence 1: NP_608926.2
• Gene: H15 / 33769
• FlyBaseID: FBgn0016660
• Length: 660
• Species: Drosophila melanogaster
• Sequence 2: NP_001030291.1
• Gene: tbx2 / 619588
• XenbaseID: XB-GENE-1018115
• Length: 685
• Species: Xenopus tropicalis
• Alignment Length: 637
• Identity: 193/637 - (30%)
• Similarity: 249/637 - (39%)
• Gaps: 240/637 - (37%)

  Fly   230 AAATPSPPP----PP-----PSQSP------------------------EELERLSPEESPAQQP 261
            |||.||..|    ||     |...|                        ..|:.|.|||.  .:.
 Frog    31 AAAQPSFFPALTLPPAALGKPLSDPSLAGAAEAGLHVSALGHHHQAAHLRSLKSLEPEEE--VED 93

  Fly   262 TPKIVGSCNCDDLTPVQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGPLRQIQPADR 326
            .||:.              ||.|||||:||:|||||:||||||||||..:|..||    :....:
 Frog    94 DPKVT--------------LEAKELWDQFHKLGTEMVITKSGRRMFPPFKVRVSG----LDKKAK 140

  Fly   327 YAVLLDVVPLDSRRYRYAYHRSSWLVAGKADPPPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTN 391
            |.:|:|:|..|..||:  :|.|.|:|||||||..|.|:|.|||.|.:.|....:.|:|.|:||||
 Frog   141 YILLMDIVAADDCRYK--FHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTN 203

  Fly   392 NEMDKSGQVVLNSMHRYQPRIHLVRLSHGQSIPGSPKELQDMDHKTFVFPETVFTAVTAYQNQLI 456
            |..||.|..:|||||:||||.|:||.:....:|.|       ..:|:|||||.|.|||||||..|
 Frog   204 NISDKHGFTILNSMHKYQPRFHIVRANDILKLPYS-------TFRTYVFPETDFIAVTAYQNDKI 261

  Fly   457 TKLKIDSNPFAKGFRD---------------SSRL------SDFDRDPMDAFFFD----QHMRTA 496
            |:||||:|||||||||               |.|:      :|.|....||...|    :....:
 Frog   262 TQLKIDNNPFAKGFRDTGNGRREKRKQLSLPSLRMYEEQCKADRDGAESDASSCDPAPGRDSLHS 326

  Fly   497 PLRFFPDPLMSQLTPQE----ADA---ASMALLEKARQHLQMFGRSPYTEMLL------------ 542
            ||...|.||....:.:|    ||:   .....:..||.|..:..|||.:...|
 Frog   327 PLSTEPSPLRLHRSNREEKFGADSDQELDRREVRTARSHSPVGHRSPPSSPRLEDRGKDKNTPEK 391

  Fly   543 ------------PHLYQRSA---------------------------AP-------PPPPPAPHL 561
                        .:::.||.                           ||       ||...|.||
 Frog   392 KSESPESRKDGGDNVFSRSLEKDKGESRRKEDSKSDPECGSLSKETFAPLMVQTDSPPHLSASHL 456

  Fly   562 SAFQL-GMWQQQW--------------PQLTAG-----------FLASANQQAAL---------- 590
            .:..| |:..||:              .|.|.|           .|||....:||
 Frog   457 QSLALSGLHGQQFFNPLNAAQPLFIHPGQFTMGPGAFSAMGMGHLLASMTGASALDNGSLSSVQG 521

  Fly   591 ALAAA-----------GANRTPPPSM------------AVAPPAPATPTSSCGSASPD----LRA 628
            |..||           .:...|.|:.            |.|..|.|.|.:|..:..|.    ...
 Frog   522 ATGAATFPFHLSQHMLASQGIPMPAFGGLFPYPYTYMAAAAAAASAMPATSAATTMPRNPFLSST 586

  Fly   629 RPQLNHYPQRFSPYQV--------------------PQHQASPPASNRAESP 660
            ||:|     ||:|||:                    |..::|.|.|:|..||
 Frog   587 RPRL-----RFNPYQIPVGIPPSTNLLTTGLSASLNPGSESSKPGSSRESSP 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
H15	NP_608926.2	T-box_TBX20-like	277..473	CDD:410319	106/210 (50%)
tbx2	NP_001030291.1	T-box_TBX2_3-like	96..277	CDD:410314	105/207 (51%)
		T-box	99..277		104/190 (55%)
		TBX	295..371	CDD:432659	17/75 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	606..660		7/28 (25%)