DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment H15 and tbr1a

DIOPT Version :9

Sequence 1:	NP_608926.2	Gene:	H15 / 33769	FlyBaseID:	FBgn0016660	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	XP_693121.1	Gene:	tbr1a / 564699	ZFINID:	ZDB-GENE-060810-93	Length:	585	Species:	Danio rerio

Alignment Length:	443	Identity:	134/443 - (30%)
Similarity:	196/443 - (44%)	Gaps:	93/443 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 SSNTNNSSNSGNSNTNSKSSSQRGRSAAAV----GAAATP-------SPPPPPPS--------QS 244
            |.|...:.::|.|....:||..|...|:.:    |....|       ||.|...|        ..
Zfish    56 SPNARETQDNGESENKPESSDPRTDFASEMFSYAGQHVVPALSGHYMSPQPVISSGLYSGMSYSY 120

  Fly   245 PEELERLSPEESPAQQPTPKIVGSCNCDDLTPVQCHLETKELWDKFHELGTEMIITKSGRRMFPT 309
            |:..|:  ...:.|....|.:.|.        .|.:|..:.||.|||...|||||||.||||||.
Zfish   121 PQPYEQ--TYANAAVYSFPAVSGK--------AQVYLCNRALWFKFHRHQTEMIITKQGRRMFPC 175

  Fly   310 VRVSFSGPLRQIQPADRYAVLLDVVPLDSRRYRYAYHRSSWLVAGKADP-PPPSRIYAHPDCPLS 373
            :..:.||    :.||..|.:.:||:..|...:|  :....|:..||||. ...:|:|.|||.|.:
Zfish   176 LTFNVSG----LDPAGHYNIAVDVILADPNHWR--FQGGKWVPCGKADTNVTGNRVYTHPDSPNT 234

  Fly   374 PEALRKQVVSFEKVKLTNNE---MDKSGQVVLNSMHRYQPRIHLVRLSHGQSIPGSPKELQDMDH 435
            .....:|.:||.|:|||||:   .:.:..:||.|:|:||||:|::.:|..:.     ::..|.|.
Zfish   235 GAHWMRQEISFGKLKLTNNKGASSNNTQMIVLQSLHKYQPRVHVIEISKNED-----EDTSDPDG 294

  Fly   436 -KTFVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDSSRLSDFDRDPMDAFFFDQHMRTAPLR 499
             :||.||||.|.:||||||..||:||||.|||||||||     ::|    ..:..|...|..|
Zfish   295 VQTFTFPETQFISVTAYQNTDITQLKIDHNPFAKGFRD-----NYD----TKYSMDNTDRLTP-- 348

  Fly   500 FFPDPLMSQLTPQEADAASMALLEKARQHLQMFGRSPYT------------EMLLPHLYQRSAAP 552
              .|...|||.|....|...||.::  |.:..:.:|.:|            .::..:..|.|:..
Zfish   349 --SDSPHSQLLPSSRYAMPSALFQE--QFVDSYTKSCFTTGTPERGLEFTNSIMTSNQTQESSVT 409

  Fly   553 PPPPPAPHLSAFQLGMWQQQW----PQLTAGFLASANQQAALALAAAGANRTP 601
            .                .|:|    |.:.: :.|..:..|.|:...||....|
Zfish   410 S----------------GQRWFVSSPSVPS-YEADVDTAALLSYTTAGVKNLP 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H15	NP_608926.2	TBOX	276..475	CDD:238106	89/203 (44%)
tbr1a	XP_693121.1	TBOX	142..335	CDD:238106	89/216 (41%)
tbr1a	XP_693121.1	T-box_assoc	355..550	CDD:292794	20/110 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574513
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740