DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment H15 and Tbx21

DIOPT Version :9

Sequence 1:	NP_608926.2	Gene:	H15 / 33769	FlyBaseID:	FBgn0016660	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_001100513.1	Gene:	Tbx21 / 303496	RGDID:	1308264	Length:	528	Species:	Rattus norvegicus

Alignment Length:	544	Identity:	153/544 - (28%)
Similarity:	230/544 - (42%)	Gaps:	136/544 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 TGKQQRQHHNHHSSNTNNSSNSGNSNTNSKSSSQRGRSAAAVGAAATPSPPP--------PPPSQ 243
            ||..|:....:..|...:.       |:.::.|..|.|.:  |:|..|:||.        ||.:|
  Rat    26 TGADQQHRFFYPESGAQDP-------TDRRAVSSLGSSYS--GSALVPAPPGRFLGAYAYPPRAQ 81

  Fly   244 S------------PEELERLSPEES-PAQQPTPKIVGSCNCDDLTP--------VQCHLETKELW 287
            :            |...|...|.:. .|..|...:......|...|        ::..|....||
  Rat    82 ATGFPGPGESFPPPAGAEGYPPVDGYAAPDPRAGLYPGPREDYALPAGLEVSGKLRVALSNHLLW 146

  Fly   288 DKFHELGTEMIITKSGRRMFPTVRVSFSGPLRQIQPADRYAVLLDVVPLDSRRYRYAYHRSSWLV 352
            .||::..|||||||.||||||.:..:.:|    ::|...|.:.:|||.:|...:|  |....|:.
  Rat   147 SKFNQHQTEMIITKQGRRMFPFLSFTVAG----LEPTSHYRMFVDVVLVDQHHWR--YQSGKWVQ 205

  Fly   353 AGKAD-PPPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNE---MDKSGQVVLNSMHRYQPRIH 413
            .|||: ..|.:|:|.|||.|.:.....:|.|||.|:|||||:   .:.:..:||.|:|:||||:|
  Rat   206 CGKAEGSMPGNRLYVHPDSPNTGAHWMRQEVSFGKLKLTNNKGASNNVTQMIVLQSLHKYQPRLH 270

  Fly   414 LVRLSHGQSIPGSPKELQDMDHKTFVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDS--SRL 476
            :|.::.|:     |:.....:...|.|.||.|.|||||||..||:||||:||||||||::  |..
  Rat   271 IVEVNDGE-----PEAACSANTHIFTFQETQFIAVTAYQNAEITQLKIDNNPFAKGFRENFESMY 330

  Fly   477 SDFDR---------------DPMDAFFFDQHMRTAPLRFFPD------PLMSQL----TPQE--- 513
            :..|.               ||......:|:..::  ||:||      .::||.    ||:|
  Rat   331 TSVDTSVPSPPGPNCQLLGGDPYSPLLSNQYPVSS--RFYPDLPGQPKDMVSQSYWLGTPREPSY 393

  Fly   514 -----ADAASMALLEKARQHLQMFGRSPYTEMLLPHLYQRSAAPPPPPPAPHLSAFQLGMWQQQW 573
                 |.:.....|..|......:.|.|  ::|.|......|...||..:|
  Rat   394 ETEFRAVSVKPTFLPSAPGTTVPYYRGP--DVLAPGAGWPMAPQYPPKMSP-------------- 442

  Fly   574 PQLTAGF------------LASANQQAALALAAAGANRTPPPS-----------MAVAP-PAPAT 614
                ||:            |.|:.:|.:.:|.....:..|.||           ..::| |:...
  Rat   443 ----AGWFRTMRTLPMDPGLGSSEEQGSPSLWTEVTSLQPEPSDSGLGEGDTKRRRISPYPSSGD 503

  Fly   615 PTSSCGSASP-DLRARPQL-NHYP 636
            .:|..|:.|| |.....|. |::|
  Rat   504 SSSPAGAPSPFDKETEGQFYNYFP 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H15	NP_608926.2	TBOX	276..475	CDD:238106	87/212 (41%)
Tbx21	NP_001100513.1	T-box	138..324	CDD:279278	85/196 (43%)
Tbx21	NP_001100513.1	T-box_assoc	<392..518	CDD:292794	27/145 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335227
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740