Protein Alignment H15 and Tbx2

DIOPT Version :9

• Sequence 1: NP_608926.2
• Gene: H15 / 33769
• FlyBaseID: FBgn0016660
• Length: 660
• Species: Drosophila melanogaster
• Sequence 2: NP_033350.2
• Gene: Tbx2 / 21385
• MGIID: 98494
• Length: 711
• Species: Mus musculus
• Alignment Length: 623
• Identity: 189/623 - (30%)
• Similarity: 244/623 - (39%)
• Gaps: 234/623 - (37%)

  Fly   222 GRSAAAVGAAATPSP-------PPPPPSQSPEELERLSPEESPAQQPTPKIVGSCNCDDLTPVQC 279
            |.:|||..|||....       .|.||:.....|:.|.||:.  .:..||:.
Mouse    59 GAAAAAAAAAAAAEAGLHVSALGPHPPAAHLRSLKSLEPEDE--VEDDPKVT------------- 108

  Fly   280 HLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGPLRQIQPADRYAVLLDVVPLDSRRYRYA 344
             ||.|||||:||:|||||:||||||||||..:|..||    :....:|.:|:|:|..|..||:
Mouse   109 -LEAKELWDQFHKLGTEMVITKSGRRMFPPFKVRVSG----LDKKAKYILLMDIVAADDCRYK-- 166

  Fly   345 YHRSSWLVAGKADPPPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNEMDKSGQVVLNSMHRYQ 409
            :|.|.|:|||||||..|.|:|.|||.|.:.|....:.|:|.|:|||||..||.|..:|||||:||
Mouse   167 FHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQ 231

  Fly   410 PRIHLVRLSHGQSIPGSPKELQDMDHKTFVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDSS 474
            ||.|:||.:....:|.|       ..:|:|||||.|.|||||||..||:||||:|||||||||:.
Mouse   232 PRFHIVRANDILKLPYS-------TFRTYVFPETDFIAVTAYQNDKITQLKIDNNPFAKGFRDTG 289

  Fly   475 RLSDFDRDPM---DAFFFDQHMR----------------------------TAPLRFF------- 501
            ......|..:   ....:::|.:                            .:|||..
Mouse   290 NGRREKRKQLTLPTLRLYEEHCKPERDGAESDASSCDPPPAREPPPSPSAAPSPLRLHRARAEEK 354

  Fly   502 -------PDPLMSQLTPQEADAA------------------------------------------ 517
                   |:|   :.|.:|..||
Mouse   355 PGAADSDPEP---ERTGEERSAAPLGRSPSRDASPARLTEPERSRERRSPERCSKEPTEGGGDGP 416

  Fly   518 -SMALLEKARQHLQM--FGRSPYTE----MLLPHLYQRSAAPPPPPPAPHLS--AFQLGMWQQQW 573
             |:..|||.|...:.  .||....|    .|.|.:.|..:|  .|..|.||.  ||...:..||:
Mouse   417 FSLRSLEKERPEARRKDEGRKDVGEGKEPSLAPLVVQTDSA--SPLGAGHLPGLAFSSHLHGQQF 479

  Fly   574 -----------------------------------------------PQLTAGF-------LASA 584
                                                           |...||.       .|||
Mouse   480 FGPLGAGQPLFLHPGQFAMGPGAFSAMGMGHLLASVAGGSGSSGGAGPGTAAGLDAGGLGPAASA 544

  Fly   585 NQQAA-------------------------------LALAAAGANRTPPPSMAVAPPAPATPTSS 618
            ...||                               :|.|||.|:..|..|.|.|..|.|...
Mouse   545 ASTAAPFPFHLSQHMLASQGIPMPTFGGLFPYPYTYMAAAAAAASALPATSAAAAAAAAAGSL-- 607

  Fly   619 CGSASPDL-RARPQLNHYPQRFSPYQVPQHQASPPASN 655
              |.||.| .|||:|     ||||||:|  ...||:::
Mouse   608 --SRSPFLGSARPRL-----RFSPYQIP--VTIPPSTS 636

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
H15	NP_608926.2	TBOX	276..475	CDD:238106	106/198 (54%)
Tbx2	NP_033350.2	TBOX	104..289	CDD:238106	108/211 (51%)
		TBX	305..382	CDD:204975	10/79 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	313..449		18/138 (13%)
		Repression domain 1 (RD1). /evidence=ECO:0000250	518..602		17/83 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	640..687

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831476
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740