DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment H15 and Tbr1

DIOPT Version :9

Sequence 1:	NP_608926.2	Gene:	H15 / 33769	FlyBaseID:	FBgn0016660	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_033348.2	Gene:	Tbr1 / 21375	MGIID:	107404	Length:	681	Species:	Mus musculus

Alignment Length:	747	Identity:	204/747 - (27%)
Similarity:	275/747 - (36%)	Gaps:	222/747 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 QQIVSAAAAAAANIANGSSHHHHHQNHH---HHHPLNNHHNHNHNQHNISFATDFSIAAIMARG- 90
            :..:|.:...:....|.||.:.|.....   |.||:.:..::......:...|         ||
Mouse     4 EHCLSPSIMLSKKFLNVSSSYPHSGGSELVLHDHPIISTTDNLERSSPLKKIT---------RGM 59

  Fly    91 ------GNAPSSREPSERSLSPASVERYSGQDADDDVDVDVVDCSDSEMPSATAAAAAAATTAAA 149
                  .|.|.|::      ||..|:|.......|.|         ||:        ..:...:|
Mouse    60 TNQSDTDNFPDSKD------SPGDVQRSKLSPVLDGV---------SEL--------RHSFDGSA 101

  Fly   150 AAAALQAQQQARQALRVAQQQQQQQQQQRQQTHHHATTGKQQRQHHNHHSSNTNNSSNSGNSNTN 214
            |...|.:|....|:...|.........|....|...:.|...| :..||...||.:.||..||
Mouse   102 ADRYLLSQSSQPQSAATAPSAMFPYPSQHGPAHPAFSIGSPSR-YMAHHPVITNGAYNSLLSN-- 163

  Fly   215 SKSSSQRGRSAAAVGAAATPSPPPPPPSQSPEELERLSPEESPAQQPTPKIVGSCNCDDLTP--V 277
               ||.:|          .|:...|.|.|.....:.....:..:.||           .|.|  .
Mouse   164 ---SSPQG----------YPTAGYPYPQQYGHSYQGAPFYQFSSTQP-----------GLVPGKA 204

  Fly   278 QCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGPLRQIQPADRYAVLLDVVPLDSRRYR 342
            |.:|..:.||.|||...|||||||.||||||.:..:.||    :.|...|.:.:||:..|...:|
Mouse   205 QVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNISG----LDPTAHYNIFVDVILADPNHWR 265

  Fly   343 YAYHRSSWLVAGKADP-PPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNE--MDKSGQ-VVLN 403
              :....|:..||||. ...:|:|.|||.|.:.....:|.:||.|:|||||:  .:.:|| |||.
Mouse   266 --FQGGKWVPCGKADTNVQGNRVYMHPDSPNTGAHWMRQEISFGKLKLTNNKGASNNNGQMVVLQ 328

  Fly   404 SMHRYQPRIHLVRLSH-GQSIPGSPKELQDMDHKTFVFPETVFTAVTAYQNQLITKLKIDSNPFA 467
            |:|:||||:|:|.::. |......|..:|     ||.||||.|.|||||||..||:||||.||||
Mouse   329 SLHKYQPRLHVVEVNEDGTEDTSQPGRVQ-----TFTFPETQFIAVTAYQNTDITQLKIDHNPFA 388

  Fly   468 KGFRDSSRL----SDFDRDPMDAFFFDQHMRTAPLRFFPDPLMSQLTPQEADAASMALLE----- 523
            |||||:...    .|.||           :..:|    .|...||:.|....|.:.:.|:
Mouse   389 KGFRDNYDTIYTGCDMDR-----------LTPSP----NDSPRSQIVPGARYAMAGSFLQDQFVS 438

  Fly   524 ---KARQHLQM-FGRSPYTEMLLPH---LYQRSAAPPPPPPAPHLSAFQLGMWQQQWPQLTAG-- 579
               |||.|... .|..|.|:..:||   |.....|..|..|:|           |:|....|.
Mouse   439 NYAKARFHPGAGAGPGPGTDRSVPHTNGLLSPQQAEDPGAPSP-----------QRWFVTPANNR 492

  Fly   580 --FLASANQQA-------------------ALALAAAGAN---------------RTPP------ 602
              |.|||...|                   ||.|.|||..               |:||
Mouse   493 LDFAASAYDTATDFAGNAATLLSYAAAGVKALPLQAAGCTGRPLGYYADPSGWGARSPPQYCGAK 557

  Fly   603 --------PSMAVA-----------------------PPAPA----------------TPTSSCG 620
                    |:.|.|                       |.|||                ||:|...
Mouse   558 SGSVLPCWPNSAAAAARMAGANPYLGEEAEGLAAERSPLAPAAEDAKPKDLSDSSWIETPSSIKS 622

  Fly   621 SASPDLRARPQLNHYPQRFSPYQVPQHQASPP 652
            ..|.|.....|...  :|.||...|..::|.|
Mouse   623 IDSSDSGIYEQAKR--RRISPADTPVSESSSP 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H15	NP_608926.2	TBOX	276..475	CDD:238106	94/205 (46%)
Tbr1	NP_033348.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..83		10/54 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..127		3/18 (17%)
		TBOX	203..396	CDD:238106	93/203 (46%)
		T-box_assoc	418..679	CDD:374412	54/248 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	447..483		10/46 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	597..655		15/58 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831492
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740