Protein Alignment H15 and Eomes

DIOPT Version :10

• Sequence 1: NP_608926.2
• Gene: H15 / 33769
• FlyBaseID: FBgn0016660
• Length: 660
• Species: Drosophila melanogaster
• Sequence 2: NP_034266.2
• Gene: Eomes / 13813
• MGIID: 1201683
• Length: 707
• Species: Mus musculus
• Alignment Length: 690
• Identity: 179/690 - (25%)
• Similarity: 253/690 - (36%)
• Gaps: 187/690 - (27%)

  Fly    91 GNAPSSREPSERSLSPASVERYSGQDADDDVDVDVVDC-SDSEMPSATAAAAAAA---------T 145
            |.|||   |....|..|| :::.|.          :.| :.|..|:...|.|.||         |
Mouse    48 GAAPS---PQRLDLDKAS-KKFPGS----------LPCQAGSAEPAGAGAGAPAAMLSDADAGDT 98

  Fly   146 TAAAAAAALQAQQQARQALRVAQQQQQQQQQQRQQTHHHATTGKQQRQHHNHHSSNTNNSSNSGN 210
            ..:.:|.|.......|:....|:::....          ||.....|...:..||......:.|.
Mouse    99 FGSTSAVAKPGPPDGRKGSPCAEEELPSA----------ATAAATARYSMDSLSSERYYLPSPGP 153

  Fly   211 SNTNSKSSSQRGRSAAAVGAAATPSPP-------------PP---PPSQSPEELERLSP------ 253
            ..:...:.....:..||.|||..|..|             ||   |.:..|....:..|
Mouse   154 QGSELAAPCSLFQYPAAAGAAHGPVYPASNGARYPYGSMLPPGGFPAAVCPPARAQFGPAAGSGS 218

  Fly   254 ------------------EESPAQQPTPKIVGSCNCDDL----TP-----VQCHLETKELWDKFH 291
                              :.||...|......:.:|..|    .|     ...:|..:.||.|||
Mouse   219 GAGSSGGGAGGPGAYPYGQGSPLYGPYAGTSAAGSCGGLGGLGVPGSGFRAHVYLCNRPLWLKFH 283

  Fly   292 ELGTEMIITKSGRRMFPTVRVSFSGPLRQIQPADRYAVLLDVVPLDSRRYRYAYHRSSWLVAGKA 356
            ...|||||||.||||||.:..:.:|    :.|...|.|.::||..|...:|  :....|:..|||
Mouse   284 RHQTEMIITKQGRRMFPFLSFNING----LNPTAHYNVFVEVVLADPNHWR--FQGGKWVTCGKA 342

  Fly   357 D-PPPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNE---MDKSGQVVLNSMHRYQPRIHLVRL 417
            | ....:::|.||:.|.:.....:|.:||.|:|||||:   .:.:..:||.|:|:||||:|:|.:
Mouse   343 DNNMQGNKMYVHPESPNTGSHWMRQEISFGKLKLTNNKGANNNNTQMIVLQSLHKYQPRLHIVEV 407

  Fly   418 SH-GQSIPGSPKELQDMDHKTFVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDS----SRLS 477
            :. |......|.:.|     ||.|.||.|.|||||||..||:||||.|||||||||:    ...|
Mouse   408 TEDGVEDLNEPSKTQ-----TFTFSETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDSMYTAS 467

  Fly   478 DFDR---DPMDAFFFDQHM---RTAPLRFFPDPLMSQLTPQEADAASMALLEKARQHLQMFGRS- 535
            :.||   .|.|:....|.:   |.....|||:|.::.| ||            ||.:   .|..
Mouse   468 ENDRLTPSPTDSPRSHQIVPGGRYGVQNFFPEPFVNTL-PQ------------ARYY---NGERT 516

  Fly   536 -PYTEMLLPHLYQRSAAPPP------PPPAPHLSAFQLGMWQQQWPQLT---------------- 577
             |.|..||........|.||      |...|..:...:|.::.::...|
Mouse   517 VPQTNGLLSPQQSEEVANPPQRWLVTPVQQPVTNKLDIGSYESEYTSSTLLPYGIKSLPLQTSHA 581

  Fly   578 ------------AGFLASANQQAALALAAAGANRTPPP------------------SMAVAPPAP 612
                        ||:......|..:|......:|..||                  |....||:.
Mouse   582 LGYYPDPTFPAMAGWGGRGAYQRKMAAGLPWTSRMSPPVFPEDQLAKEKVKEEISSSWIETPPSI 646

  Fly   613 ATPTSSCGSASPDLRARPQLNHYPQRFSPYQVPQHQASPP 652
            .:..||..........|       :|.|| ..|.:..|||
Mouse   647 KSLDSSDSGVYNSACKR-------KRLSP-STPSNGNSPP 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
H15	NP_608926.2	T-box_TBX20-like	277..473	CDD:410319	85/200 (43%)
Eomes	NP_034266.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..125		21/90 (23%)
		T-box_TBR2	268..458	CDD:410331	84/200 (42%)
		T-box_assoc	484..705	CDD:465042	43/219 (20%)
		Required for transcription activation. /evidence=ECO:0000250	592..707		20/95 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	642..689		12/45 (27%)