DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nompC and ANKRD44

DIOPT Version :9

Sequence 1:	NP_523483.2	Gene:	nompC / 33768	FlyBaseID:	FBgn0016920	Length:	1761	Species:	Drosophila melanogaster
Sequence 2:	NP_001354424.1	Gene:	ANKRD44 / 91526	HGNCID:	25259	Length:	1074	Species:	Homo sapiens

Alignment Length:	1071	Identity:	309/1071 - (28%)
Similarity:	472/1071 - (44%)	Gaps:	152/1071 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 DMNT----GMTPLMYATKDNKTAIMDRMIELGADVGARNNDNYNVLHIAAMYSREDVVKLLLTKR 183
            |:||    ..|||..|.......|::.:|..||.|.|::|.....||.|.....|:.|::|: |.
Human    33 DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLI-KH 96

  Fly   184 GVDPFSTGGSRSQTAVHLVSSRQTGTATNILRALLAAAGKDIRLKADGRGKIPLLLAVESGNQSM 248
            ..| .:......||.:|:.::.:......::..||::..     .:|..|:..|..|..:|:..|
Human    97 SAD-VNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVN-----VSDRGGRTALHHAALNGHVEM 155

  Fly   249 CRELLAAQTAEQLKATTANGDTALHLAARRRDVDMVRILVDYGTNVDTQNGEGQTPLHIAAAEGD 313
            ...|||  ....:.|.......|||.||....:|:|.:|:::|..|..::.:|.||||.||:.|.
Human   156 VNLLLA--KGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQ 218

  Fly   314 EALLKYFYGVRASASIADNQDRTPMHLAAENGHAHVIEILADKFKASIFERTKDGSTLMHIASLN 378
            ..::|:...:.......:....|.:|:|..||...|:..|.| :.|::.:...:|.|.:|.|:.:
Human   219 INVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELID-YGANVNQPNNNGFTPLHFAAAS 282

  Fly   379 GH-AECATMLFKKGVYLHMPNKDGARSIHTAAAYGHTGIINTLLQKGEKVDVTTNDNYTALHIAV 442
            .| |.|..:|...|..:::.:|||...:|..|.:|......||:|.|.::|....|..|.||:|.
Human   283 THGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAA 347

  Fly   443 ESAKPAVVETLLGFGADVHVRGGKLRETPLHIAARVKDGDRCALMLLKSG--------------- 492
            ......::.||:..|||. .:.|.....|||:||.....| |...||.||
Human   348 RYGHELLINTLITSGADT-AKCGIHSMFPLHLAALNAHSD-CCRKLLSSGQKYSIVSLFSNEHVL 410

  Fly   493 -ASPNLTTDD-----CLTPVHVAARHGNLATLMQLLEDEGDPLYKSN-TGETPLHMACRACHPDI 550
             |...:.|.|     ||   |.||..||:..: :||:..|...:|.: .|.||||.|...||
Human   411 SAGFEIDTPDKFGRTCL---HAAAAGGNVECI-KLLQSSGADFHKKDKCGRTPLHYAAANCH--- 468

  Fly   551 VRHLIETVKEKHGPDKATT--YINSVNEDGATALHY--------------TCQITKEEV----KI 595
             .|.|||:        .||  .:|..::.|.|||||              ......||:    ::
Human   469 -FHCIETL--------VTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERAREL 524

  Fly   596 PESDKQI-VRMLLENGADVTLQTKTALETAFHYCAVAGNNDVLMEMISHMNPTDIQKAMNRQSSV 659
            .|.:..: :..||:|.|:.:::.|... .:.||.|..|:...|..::...|      :...:|..
Human   525 KEKEATLCLEFLLQNDANPSIRDKEGY-NSIHYAAAYGHRQCLELLLERTN------SGFEESDS 582

  Fly   660 GWT--PLLIACHRGHMELVNNLLANHARVDVFDTEGRSALHLAAERGYLHVCDALLTNKAFINSK 722
            |.|  ||.:|.:.||.:.:..||.:...:|:.|.:||:||.|||.:|:....:||:...|.|..|
Human   583 GATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINQGASIFVK 647

  Fly   723 SRV-GRTALHLAAMNGFTHLVKFL--IKDHNAVIDILTLRKQTPLHLAAASGQMEVCQLLLELGA 784
            ..| .||.||.:.:||.|..::.|  |.|:...:|:...:.||||.||.|.|.::...||||..|
Human   648 DNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEA 712

  Fly   785 NIDATDDLGQKPIHVAAQNNYSEVAKLFLQQHPSLVNATSKDGNTCAHIAAMQGSVKVIEELMKF 849
            |:|..|.||...:|......:.|..::.|:|..|::...|: |.|..|.||.:|....:.||::.
Human   713 NVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSR-GRTPLHYAAARGHATWLSELLQM 776

  Fly   850 ----------DRSGVISARNKLTDATPLQLAAEGGHADVVKALVRAGASCTEENKA-------GF 897
                      |..|.          |||..|...|:.:.::.|:        |.|.       .|
Human   777 ALSEEDCCFKDNQGY----------TPLHWACYNGNENCIEVLL--------EQKCFRKFIGNPF 823

  Fly   898 TAVHLAAQNGHGQVLDVLKSTNSLRINSKK--LGLTPLHVAAYYGQADTVRELLT-SVPATVKSE 959
            |.:|.|..|.||....:|.......|.|.:  .|.||||.||:....:.::.||. |.|.....
Human   824 TPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLHAAAFADHVECLQLLLRHSAPVNAVD- 887

  Fly   960 TPTGQSLFGDLGTESGMTPLHLAAFSGNENVVRLLLNSAGVQVDAATIENGYN-PLHLACFGGHM 1023
                         .||.|.|.:||.:|....|.:|:|||  |.|....:...| ||||||..||.
Human   888 -------------NSGKTALMMAAENGQAGAVDILVNSA--QADLTVKDKDLNTPLHLACSKGHE 937

  Fly  1024 SVVGLLLSR--SAELLQSQDRNGRTGLHIAAMHGHIQMVEILLGQGAEINATDRNGWTP-LHCAA 1085
            ....|:|.:  ...|:..::...:|.||:||.:|...:||.||.:||.:.|.|.||.|| |.||.
Human   938 KCALLILDKIQDESLINEKNNALQTPLHVAARNGLKVVVEELLAKGACVLAVDENGHTPALACAP 1002

  Fly  1086 KAGHLEVVKLLCEA--GASPKS---ETNYGC 1111
            .....:.:.|:...  ..||.|   ..|:.|
Human  1003 NKDVADCLALILATMMPFSPSSTMMAVNFVC 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nompC	NP_523483.2	ANK repeat	129..157	CDD:293786	10/27 (37%)
		Ank_2	131..228	CDD:289560	22/96 (23%)
		ANK	155..319	CDD:238125	43/163 (26%)
		ANK repeat	159..186	CDD:293786	7/26 (27%)
		ANK repeat	232..265	CDD:293786	9/32 (28%)
		Ank_2	237..331	CDD:289560	27/93 (29%)
		ANK	263..387	CDD:238125	36/124 (29%)
		ANK repeat	267..298	CDD:293786	10/30 (33%)
		ANK repeat	300..331	CDD:293786	9/30 (30%)
		Ank_2	305..398	CDD:289560	24/93 (26%)
		ANK	329..454	CDD:238125	35/125 (28%)
		ANK repeat	367..398	CDD:293786	9/31 (29%)
		ANK repeat	400..431	CDD:293786	10/30 (33%)
		Ank_2	405..498	CDD:289560	31/108 (29%)
		ANK	428..555	CDD:238125	46/148 (31%)
		ANK repeat	433..463	CDD:293786	10/29 (34%)
		ANK repeat	469..499	CDD:293786	12/45 (27%)
		ANK	496..641	CDD:238125	47/171 (27%)
		ANK repeat	501..532	CDD:293786	11/35 (31%)
		Ank_2	507..616	CDD:289560	37/130 (28%)
		ANK repeat	534..575	CDD:293786	15/42 (36%)
		ANK repeat	577..616	CDD:293786	13/57 (23%)
		Ank_2	625..722	CDD:289560	30/98 (31%)
		ANK	654..780	CDD:238125	46/130 (35%)
		ANK repeat	660..690	CDD:293786	10/31 (32%)
		ANK repeat	692..723	CDD:293786	12/30 (40%)
		Ank_2	697..790	CDD:289560	37/95 (39%)
		ANK	720..847	CDD:238125	44/129 (34%)
		ANK repeat	725..757	CDD:293786	12/34 (35%)
		ANK repeat	759..790	CDD:293786	15/30 (50%)
		Ank_5	779..834	CDD:290568	18/54 (33%)
		ANK	787..915	CDD:238125	35/144 (24%)
		ANK repeat	792..824	CDD:293786	7/31 (23%)
		ANK repeat	861..893	CDD:293786	6/31 (19%)
		Ank_4	865..915	CDD:290365	15/56 (27%)
		Ank_4	929..995	CDD:290365	19/66 (29%)
		ANK repeat	932..972	CDD:293786	9/40 (23%)
		ANK	969..1096	CDD:238125	47/130 (36%)
		ANK repeat	974..1007	CDD:293786	14/32 (44%)
		Ank_2	979..1074	CDD:289560	36/97 (37%)
		ANK repeat	1009..1041	CDD:293786	12/34 (35%)
		ANK	1039..1159	CDD:238125	27/79 (34%)
		ANK repeat	1043..1074	CDD:293786	13/30 (43%)
		Ank_2	1048..1135	CDD:289560	26/70 (37%)
		ANK repeat	1076..1101	CDD:293786	8/27 (30%)
		ANK repeat	1109..1134	CDD:293786	1/3 (33%)
		Ion_trans	<1393..1598	CDD:278921
ANKRD44	NP_001354424.1	ANK 1	7..36		1/2 (50%)
		ANK 2	40..69		9/28 (32%)
		ANK 3	73..102		8/30 (27%)
		ANK 4	106..135		5/33 (15%)
		ANK 5	139..168		8/30 (27%)
		ANK 6	172..201		10/28 (36%)
		ANK 7	205..234		9/28 (32%)
		ANK 8	238..267		9/29 (31%)
		ANK 9	271..301		9/29 (31%)
		ANK 10	305..334		9/28 (32%)
		ANK 11	338..367		10/29 (34%)
		ANK 13	422..451		10/32 (31%)
		ANK 14	455..484		14/40 (35%)
		ANK 15	488..516		6/27 (22%)
		ANK 16	549..579		6/36 (17%)
		ANK 17	584..613		8/28 (29%)
		ANK 18	617..646		12/28 (43%)
		ANK 19	651..680		10/28 (36%)
		ANK 20	687..716		14/28 (50%)
		ANK 21	720..749		7/28 (25%)
		ANK 22	753..782		8/29 (28%)
		ANK 23	789..818		9/46 (20%)
		ANK 24	821..850		8/28 (29%)
		ANK 25	856..885		11/28 (39%)
		ANK 26	889..919		14/31 (45%)
		ANK 27	923..952		11/28 (39%)
		ANK 28	959..988		12/28 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	323	1.000	Inparanoid score	I2508
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.870