DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nompC and TNKS2

DIOPT Version :9

Sequence 1:	NP_523483.2	Gene:	nompC / 33768	FlyBaseID:	FBgn0016920	Length:	1761	Species:	Drosophila melanogaster
Sequence 2:	XP_005270242.2	Gene:	TNKS2 / 80351	HGNCID:	15677	Length:	1190	Species:	Homo sapiens

Alignment Length:	938	Identity:	253/938 - (26%)
Similarity:	364/938 - (38%)	Gaps:	249/938 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 GRGKIPLLLAVESGNQSMCRELLAAQTAEQLKATTANGDTALHLAARRRDVDMVRILVDYGTNVD 295
            ||...||..|  :||:.. |.|.:.||.......|..|         |:||  |..|:..|.||.
Human    56 GRKSTPLHFA--AGNRGQ-RPLASLQTPPAQPGPTGFG---------RKDV--VEYLLQNGANVQ 106

  Fly   296 TQNGEGQTPLHIAAAEGDEALLKYFYGVRASASIADNQDRTPMHLAAENGHAHV-IEILADKFKA 359
            .::..|..|||.|.:.|...::.......|..:..||.:.||:|.||..|...| |.:|....:.
Human   107 ARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEP 171

  Fly   360 SIFERTKDGSTLMHIASLNGHAECATMLFKKGVYLHMPN--------------------KDGARS 404
            :|  |..||.|.:.:|..:..| ..|..:||...|....                    .||.:|
Human   172 TI--RNTDGRTALDLADPSAKA-VLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKS 233

  Fly   405 --IHTAAAYGHTGIINTLLQKGEKVDVTTNDNYTALHIAVESAKPAVVETLLGFGADVHVRGGKL 467
              :|.||.|....|:..|||.|..|......:...||.|.......|.|.|:..||.|:.. ...
Human   234 TPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAM-DLW 297

  Fly   468 RETPLHIAARVKDGDRCALMLLKSGASPNLTTDDCLTPVHVAARHGNLATLMQLLEDEGDPLYKS 532
            :.||||.||.....:.|:| ||..||.|.|.  :|.....:     :||...||.|    .|...
Human   298 QFTPLHEAASKNRVEVCSL-LLSYGADPTLL--NCHNKSAI-----DLAPTPQLKE----RLAYE 350

  Fly   533 NTGETPLHMACRACHPDIVRHL-IETVKEKHGPDKATTYINSVNEDGATALHYTCQITKEEVKIP 596
            ..|.:.|..|..|....|.:|| :|.|..||            .:...||||  |.......|
Human   351 FKGHSLLQAAREADVTRIKKHLSLEMVNFKH------------PQTHETALH--CAAASPYPK-- 399

  Fly   597 ESDKQIVRMLLENGADVTLQTKTALETAFHYCAVAGNNDVLMEMISHMNPTDIQKAMNRQSSVGW 661
              .|||..:||..||::..:||..|
Human   400 --RKQICELLLRKGANINEKTKEFL---------------------------------------- 422

  Fly   662 TPLLIACHRGHMELVNNLLANHARVDVFDTEGRSALHLAAERGYLHVCDALLTNKAFINSKSRVG 726
            |||.:|..:.|.::|..::.:.|:|:..|..|:::||.||..|:|..|..||:.....|..|..|
Human   423 TPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQG 487

  Fly   727 RTALHLAAMNGFTHLVKFLIKD--HN-------------------AVIDILTL------------ 758
            .|||.:...|     |:.|::|  ||                   ::..|..|
Human   488 FTALQMGNEN-----VQQLLQDLVHNLPNCKRTLLSDEMPSIKLGSIFQIEKLCTVQSVNCRDIE 547

  Fly   759 -RKQTPLHLAAASGQMEVCQLLLELGANIDATDDLGQKPIHVAAQNNYSEVAKLFLQQHPSLVNA 822
             |:.||||.||...::.|.:.||:.||::.|.|..|..|:|.|....:.|||:| |.:|.::||
Human   548 GRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAEL-LVKHGAVVN- 610

  Fly   823 TSKDGNTCAHIAAMQGSVKVIEELMKFDRSGVISARNKLTDATPLQLAAEGGHADVVKALVRAGA 887
                                :.:|.||               |||..||..|..::.|.|::.||
Human   611 --------------------VADLWKF---------------TPLHEAAAKGKYEICKLLLQHGA 640

  Fly   888 SCTEENKAGFTAVHLAAQNGHGQVLDVLKSTNSLRINSKKLGLTPLHVAAYYGQADTVRELLTSV 952
            ..|::|:.|.|.:.| .::|...:.|:|:...:|...:||            |....|::|  |.
Human   641 DPTKKNRDGNTPLDL-VKDGDTDIQDLLRGDAALLDAAKK------------GCLARVKKL--SS 690

  Fly   953 PATVKSETPTGQSLFGDLGTESGMTPLHLAAFSGNENVVRLLLNSAGVQVDAATIENGYNPLHLA 1017
            |..|......|:.          .|||||||                          |||.|.:|
Human   691 PDNVNCRDTQGRH----------STPLHLAA--------------------------GYNNLEVA 719

  Fly  1018 CFGGHMSVVGLLLSRSAELLQSQDRNGRTGLHIAAMHGHIQMVEILLGQGAEINATDRNGWTPLH 1082
            .:         ||...|: :.:||:.|...||.||.:||:.:..:|:...|.:||||:..:||||
Human   720 EY---------LLQHGAD-VNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLH 774

  Fly  1083 CAAKAGHLEVVKLLCEAGASPKSETNYG 1110
            .||:.|..::..||...||.|..:...|
Human   775 EAAQKGRTQLCALLLAHGADPTLKNQEG 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nompC	NP_523483.2	ANK repeat	129..157	CDD:293786
		Ank_2	131..228	CDD:289560
		ANK	155..319	CDD:238125	27/87 (31%)
		ANK repeat	159..186	CDD:293786
		ANK repeat	232..265	CDD:293786	10/32 (31%)
		Ank_2	237..331	CDD:289560	25/93 (27%)
		ANK	263..387	CDD:238125	36/124 (29%)
		ANK repeat	267..298	CDD:293786	9/30 (30%)
		ANK repeat	300..331	CDD:293786	7/30 (23%)
		Ank_2	305..398	CDD:289560	27/93 (29%)
		ANK	329..454	CDD:238125	40/147 (27%)
		ANK repeat	367..398	CDD:293786	9/30 (30%)
		ANK repeat	400..431	CDD:293786	13/32 (41%)
		Ank_2	405..498	CDD:289560	32/92 (35%)
		ANK	428..555	CDD:238125	37/127 (29%)
		ANK repeat	433..463	CDD:293786	9/29 (31%)
		ANK repeat	469..499	CDD:293786	14/29 (48%)
		ANK	496..641	CDD:238125	35/145 (24%)
		ANK repeat	501..532	CDD:293786	7/30 (23%)
		Ank_2	507..616	CDD:289560	30/109 (28%)
		ANK repeat	534..575	CDD:293786	11/41 (27%)
		ANK repeat	577..616	CDD:293786	13/38 (34%)
		Ank_2	625..722	CDD:289560	20/96 (21%)
		ANK	654..780	CDD:238125	41/159 (26%)
		ANK repeat	660..690	CDD:293786	8/29 (28%)
		ANK repeat	692..723	CDD:293786	11/30 (37%)
		Ank_2	697..790	CDD:289560	36/126 (29%)
		ANK	720..847	CDD:238125	40/160 (25%)
		ANK repeat	725..757	CDD:293786	11/52 (21%)
		ANK repeat	759..790	CDD:293786	13/30 (43%)
		Ank_5	779..834	CDD:290568	18/54 (33%)
		ANK	787..915	CDD:238125	34/127 (27%)
		ANK repeat	792..824	CDD:293786	12/31 (39%)
		ANK repeat	861..893	CDD:293786	11/31 (35%)
		Ank_4	865..915	CDD:290365	17/49 (35%)
		Ank_4	929..995	CDD:290365	14/65 (22%)
		ANK repeat	932..972	CDD:293786	7/39 (18%)
		ANK	969..1096	CDD:238125	37/126 (29%)
		ANK repeat	974..1007	CDD:293786	7/32 (22%)
		Ank_2	979..1074	CDD:289560	26/94 (28%)
		ANK repeat	1009..1041	CDD:293786	8/31 (26%)
		ANK	1039..1159	CDD:238125	28/72 (39%)
		ANK repeat	1043..1074	CDD:293786	11/30 (37%)
		Ank_2	1048..1135	CDD:289560	25/63 (40%)
		ANK repeat	1076..1101	CDD:293786	9/24 (38%)
		ANK repeat	1109..1134	CDD:293786	1/2 (50%)
		Ion_trans	<1393..1598	CDD:278921
TNKS2	XP_005270242.2	Ank_2	28..142	CDD:372319	28/99 (28%)
		ANK repeat	60..109	CDD:293786	19/62 (31%)
		PHA02876	<94..>479	CDD:165207	124/460 (27%)
		ANK repeat	111..142	CDD:293786	7/30 (23%)
		ANK repeat	144..175	CDD:293786	10/32 (31%)
		ANK repeat	234..262	CDD:293786	10/27 (37%)
		ANK repeat	264..295	CDD:293786	9/31 (29%)
		ANK repeat	297..328	CDD:293786	14/33 (42%)
		ANK repeat	386..418	CDD:293786	13/37 (35%)
		ANK repeat	420..451	CDD:293786	9/70 (13%)
		ANK repeat	453..482	CDD:293786	10/28 (36%)
		PHA03095	540..>826	CDD:222980	100/361 (28%)
		ANK repeat	552..580	CDD:293786	12/27 (44%)
		ANK repeat	582..613	CDD:293786	12/52 (23%)
		ANK repeat	615..646	CDD:293786	13/45 (29%)
		ANK repeat	668..698	CDD:293786	9/43 (21%)
		ANK repeat	705..733	CDD:293786	15/63 (24%)
		ANK repeat	735..766	CDD:293786	11/30 (37%)
		ANK repeat	768..799	CDD:293786	12/30 (40%)
		SAM_tankyrase1,2	895..960	CDD:188923
		tankyrase_like	962..1184	CDD:238718
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810