DRSC/TRiP Functional Genomics Resources

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Protein Alignment nompC and ANKRD53

DIOPT Version :9

Sequence 1:NP_523483.2 Gene:nompC / 33768 FlyBaseID:FBgn0016920 Length:1761 Species:Drosophila melanogaster
Sequence 2:NP_001108588.1 Gene:ANKRD53 / 79998 HGNCID:25691 Length:530 Species:Homo sapiens


Alignment Length:345 Identity:80/345 - (23%)
Similarity:132/345 - (38%) Gaps:71/345 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   899 AVHLAAQNGHGQVLDVLKSTNSLRINSKKLGLTPLHVAAYYGQADTVRELLTSVPATVKSETPTG 963
            |.||:||            ..:|....:...|||       .:||       ..|:....:|...
Human    64 ADHLSAQ------------ATALARPRRPASLTP-------PRAD-------PSPSKESDQT
AID 102

  Fly   964 QSLFGDLGTESGMTPLHLAAFSGNENVVRLLLNSAGVQVDAATIENGYNPLHLACFGGHMSVVGL 1028
            |:..|....       ..||..||...:|..||.:..::  .|.:.|:..:|.|...|.::.:.:
Human   103 QTAIGSYYQ-------LFAAAVGNVEWLRFCLNQSLREI--PTDDKGFTAIHFAAQWGKLACLQV 158

  Fly  1029 LLSRSAELLQSQDRNGRTGLHIAAMHGH----IQMVEILLGQGAEINATDRNGWTPLHCAAKAGH 1089
            |:......:.....|.:|.||:.....:    :..:..||.:||::||...||.||||.||:.|.
Human   159 LVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGL 223

  Fly  1090 LEVVKLLCEAGASPKSETNYGCAAIWFAASEGHNEVLRYL------MNKEHDTYGLMEDKRFVYN 1148
            |:.||:|.::||:..::...|...|.|.....|....|:|      .:|:.....:.:.|.|...
Human   224 LDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKDAMWKKDKKDFAREMTKMKMFKSQ 288

  Fly  1149 LMVVSKNH------NNKPIQEFV--------------LVSPAPVDTAAKLSNIYIVLSTKEKERA 1193
            |.::..|:      .:|.::|..              |||......|..||.   ....:|.:|:
Human   289 LTLMEHNYLIEYQKEHKILREAAIRKWLHGKLHPGHSLVSNTKQARATALSK---TPEQRESQRS 350

  Fly  1194 KDL---VAAGKQCEAMATEL 1210
            :..   |.|..||....||:
Human   351 RSFHPSVDARLQCIPQPTEM 370

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nompCNP_523483.2 ANK repeat 129..157 CDD:293786
Ank_2 131..228 CDD:289560
ANK 155..319 CDD:238125
ANK repeat 159..186 CDD:293786
ANK repeat 232..265 CDD:293786
Ank_2 237..331 CDD:289560
ANK 263..387 CDD:238125
ANK repeat 267..298 CDD:293786
ANK repeat 300..331 CDD:293786
Ank_2 305..398 CDD:289560
ANK 329..454 CDD:238125
ANK repeat 367..398 CDD:293786
ANK repeat 400..431 CDD:293786
Ank_2 405..498 CDD:289560
ANK 428..555 CDD:238125
ANK repeat 433..463 CDD:293786
ANK repeat 469..499 CDD:293786
ANK 496..641 CDD:238125
ANK repeat 501..532 CDD:293786
Ank_2 507..616 CDD:289560
ANK repeat 534..575 CDD:293786
ANK repeat 577..616 CDD:293786
Ank_2 625..722 CDD:289560
ANK 654..780 CDD:238125
ANK repeat 660..690 CDD:293786
ANK repeat 692..723 CDD:293786
Ank_2 697..790 CDD:289560
ANK 720..847 CDD:238125
ANK repeat 725..757 CDD:293786
ANK repeat 759..790 CDD:293786
Ank_5 779..834 CDD:290568
ANK 787..915 CDD:238125 5/15 (33%)
ANK repeat 792..824 CDD:293786
ANK repeat 861..893 CDD:293786
Ank_4 865..915 CDD:290365 5/15 (33%)
Ank_4 929..995 CDD:290365 14/65 (22%)
ANK repeat 932..972 CDD:293786 7/39 (18%)
ANK 969..1096 CDD:238125 35/130 (27%)
ANK repeat 974..1007 CDD:293786 7/32 (22%)
Ank_2 979..1074 CDD:289560 23/98 (23%)
ANK repeat 1009..1041 CDD:293786 5/31 (16%)
ANK 1039..1159 CDD:238125 36/135 (27%)
ANK repeat 1043..1074 CDD:293786 10/34 (29%)
Ank_2 1048..1135 CDD:289560 30/96 (31%)
ANK repeat 1076..1101 CDD:293786 13/24 (54%)
ANK repeat 1109..1134 CDD:293786 7/30 (23%)
Ion_trans <1393..1598 CDD:278921
ANKRD53NP_001108588.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..99 12/60 (20%)
Ank_4 112..160 CDD:290365 12/49 (24%)
ANK 136..263 CDD:238125 36/126 (29%)
ANK 1 139..169 5/29 (17%)
ANK repeat 140..171 CDD:293786 5/30 (17%)
Ank_2 144..241 CDD:289560 29/96 (30%)
ANK repeat 173..208 CDD:293786 10/34 (29%)
ANK 2 173..206 8/32 (25%)
ANK repeat 210..241 CDD:293786 15/30 (50%)
ANK 3 210..239 15/28 (54%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 323..360 9/39 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 383..402
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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