back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nompC and ank1b

DIOPT Version :10

Sequence 1:	NP_523483.2	Gene:	nompC / 33768	FlyBaseID:	FBgn0016920	Length:	1761	Species:	Drosophila melanogaster
Sequence 2:	XP_021324740.2	Gene:	ank1b / 797662	ZFINID:	ZDB-GENE-091113-6	Length:	1963	Species:	Danio rerio

Alignment Length:	1091	Identity:	317/1091 - (29%)
Similarity:	481/1091 - (44%)	Gaps:	227/1091 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 RNNDNYNVLHIAAMYSREDVVKLLLTKRGVDPFSTGGSRSQTAVHLVSSRQTGTATNILRALLAA 220
            |:.|.....|         ||:..|..:.....:.|.|.:|........|...| |:.|||..:.
Zfish    35 RSRDRRRKAH---------VVQRWLVHQDSSLSAEGSSETQGGKWHFDGRADAT-TSFLRAARSG 89

  Fly   221 ----------AGKDIRLKADGRGKIPLLLAVESGNQSMCRELLAAQTAEQLKATTANGDTALHLA 275
                      .|.||.: |:..|...|.||.:.|:..|..|||  .....|:.||..|:||||:|
Zfish    90 NLEKALDHIKNGIDINI-ANQNGLNGLHLASKEGHVKMVLELL--HNGIDLETTTKKGNTALHIA 151

  Fly   276 ARRRDVDMVRILVDYGTNVDTQNGEGQTPLHIAAAEGDEALLKYFYGVRASASIADNQDRTPMHL 340
            |......:|..|::||.||:.|:.:|.:||::||.|....::||.....|:.|:......||:.:
Zfish   152 ALAGQEKVVAELINYGANVNAQSQKGFSPLYMAAQENHLEVVKYLLEHGANQSLPTEDGFTPLAV 216

  Fly   341 AAENGHAHVIEILAD---KFKASIFERTKDGSTLMHIASLNGHAECATMLFKKGVYLHMPNKDGA 402
            |.:.||.:|:.:|.:   |.|..:        ..:|||:.|                     |..
Zfish   217 ALQQGHENVVALLINYGTKGKVRL--------PALHIAARN---------------------DDT 252

  Fly   403 RSIHTAAAYGHTGIINTLLQKGEKVDVTTNDNYTALHIAVESAKPAVVETLLGFGADVHVRGGKL 467
            |   |||         .|||.....||.:...:|.||||......:|.:.||..||:|:.. .|.
Zfish   253 R---TAA---------VLLQNDPNPDVLSKTGFTPLHIAAHYENLSVAQLLLNRGANVNFT-PKN 304

  Fly   468 RETPLHIAARVKDGDRCALMLLKSGASPNLTTDDCLTPVHVAARHGNLATLMQLLEDEGDPLY-K 531
            ..||||||:| :.......:||..||..:..|.|.|||:|.|||:|:: .::::|.|:|.||. |
Zfish   305 GITPLHIASR-RGNVIMVRLLLDRGAQIDAKTKDELTPLHCAARNGHV-RVVEILLDQGAPLQAK 367

  Fly   532 SNTGETPLHMACRACHPDIVRHLIETVKEKHGPDKATTYINSVNEDGATALHYTCQITKEEVKIP 596
            :..|.:|:|||.:..|.|.||.|::...|          |:.:..|..|.||.....
Zfish   368 TKNGLSPIHMAAQGDHMDCVRQLLQYNAE----------IDDITLDHLTPLHVAAHC-------- 414

  Fly   597 ESDKQIVRMLLENGADVTLQTKTALETAFHYCAVAGNNDVLMEMISHMNPTDIQKAMNRQSSVGW 661
             ...::|::||:.||...                                   .:|:|     |:
Zfish   415 -GHHRMVKVLLDKGAKAN-----------------------------------ARALN-----GF 438

  Fly   662 TPLLIACHRGHMELVNNLLANHARVDVFDTEGRSALHLAAERGYLHVCDALLTNKAFINSKSRVG 726
            |||.|||.:.||..::.||.:.|.::.....|.:.||:||..|:|::..:||...|..|:.:...
Zfish   439 TPLHIACKKNHMRSMDLLLKHSASLEAVTESGLTPLHVAAFMGHLNIVKSLLQRGASPNASNVKV 503

  Fly   727 RTALHLAAMNGFTHLVKFLIKDHNAVIDILTLRKQTPLHLAAASGQMEVCQLLLELGANIDATDD 791
            .|.||:||..|...:.:||:: :||.:|......|||||.||..|..|:.:||:|..||.|:...
Zfish   504 ETPLHMAARAGHCEVAQFLLQ-NNAQVDAKAKDDQTPLHCAARMGHKELVKLLMEHKANPDSATT 567

  Fly   792 LGQKPIHVAAQNNYSEVAKLFLQQHPSLVNATSKDGNTCAHIAAMQGSVKVIEELMKFDRSGVIS 856
            .|..|:|:||:..:::..::.|.::......|.| |.|..|:|...|.|.|.|.|::...:...:
Zfish   568 AGHTPLHIAAREGHAQTTRILLDENAQQTKMTKK-GFTPLHVACKYGKVDVAELLLERGANPNAA 631

  Fly   857 ARNKLTDATPLQLAAEGGHADVVKALVRAGASCTEENKAGFTAVHLAAQNGHGQVLDVLKSTNSL 921
            .:|.|   |||.:|....:.||||.||..|.|.....:.|:||:|:||:....:|...|....:
Zfish   632 GKNGL---TPLHVAVHHNNLDVVKLLVSKGGSPHSTARNGYTALHIAAKQNQLEVASSLLQYGA- 692

  Fly   922 RINSKKL-GLTPLHVAAYYGQADTVRELLTSVPATVKSETPTGQSLFGDLGTESGMTPLHLAAFS 985
            ..||:.| |:||||:|:..||.|.| .||.|..|.|            :||.::|:|||||.|..
Zfish   693 NANSESLQGITPLHLASQEGQPDMV-ALLISKQANV------------NLGNKNGLTPLHLVAQE 744

  Fly   986 GNENVVRLLLNSAGVQVDAATIENGYNPLHLACFGGHMSVVGLLLSRSAELLQSQDRNGRTGLHI 1050
            |:..:..:|:.. |..|.||: ..||.|||:||.
Zfish   745 GHVGIADMLVKQ-GASVYAAS-RMGYTPLHVACH------------------------------- 776

  Fly  1051 AAMHGHIQMVEILLGQGAEINATDRNGWTPLHCAAKAGHLEVVKLLCEAGASPKSETNYGCAAIW 1115
               :|:|:||:.||.|.|.:|:..|.|:||||.||:.||.::|.||.:.||.|...|..|.:.:.
Zfish   777 ---YGNIKMVKFLLQQQAHVNSKTRLGYTPLHQAAQQGHTDIVTLLLKHGALPNEITTNGTSPLG 838

  Fly  1116 FAASEGHNEVLRYLMNKEHDTYGLMEDKRFVYNLMVVSKNHNNKPIQEFVLVSPAPVDTAAKLSN 1180
            .|...|:..|:        |...|:.::..   .|:.::.|.        :..|..||.
Zfish   839 IAKRLGYISVI--------DVLKLVTEESV---SMITTEKHR--------MSFPETVDE------ 878

  Fly  1181 IYIVLSTKEKERAKDLVAAGKQCEAMATELLALAAGSDSAGKILQATDKRN 1231
               :|...|.|....|        .:..|||    |.|.| :.|:..|.::
Zfish   879 ---ILDVSEDEGVAQL--------TLGDELL----GMDGA-RYLKLDDLKD 913

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.