DRSC/TRiP Functional Genomics Resources

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Protein Alignment nompC and Tnks2

DIOPT Version :9

Sequence 1:NP_523483.2 Gene:nompC / 33768 FlyBaseID:FBgn0016920 Length:1761 Species:Drosophila melanogaster
Sequence 2:NP_001157107.1 Gene:Tnks2 / 74493 MGIID:1921743 Length:1166 Species:Mus musculus


Alignment Length:1121 Identity:265/1121 - (23%)
Similarity:417/1121 - (37%) Gaps:332/1121 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   243 SGNQSMCRELLAAQTAEQLKATTANGDTALHLAARRRDVDMVRILV--DYGTNVDTQNGEGQTPL 305
            :|..:.|    |:..||.::.:...    |..|.|..||:.|:.||  :...:.||. |...|||
Mouse     7 AGGGAAC----ASAGAEAVEPSARE----LFEACRNGDVERVKRLVTPEKVNSRDTA-GRKSTPL 62

  Fly   306 HIAAAEGDEALLKYFYGVRASASIADNQDRTPMHLAAENGHAHVIEILADKFKASIFERTKDGST 370
            |.||..|.:.:::|.....|:....|:....|:|.|...|||.|:.:|                 
Mouse    63 HFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLL----------------- 110

  Fly   371 LMHIASLNGHAECATMLFKKGVYLHMPNKDGARSIHTAAAYGHTGIINTLLQKGEKVDVTTNDNY 435
            |.|.|..|.          :..:.:.|       :|.||..|...:...|||.|.:..:...|..
Mouse   111 LQHGADPNA----------RDNWNYTP-------LHEAAIKGKIDVCIVLLQHGAEPTIRNTDGR 158

  Fly   436 TALHIAVESAKPAVV-----ETLLGFGADVHVRGGKLRE-----TPLHIAARVKDGDRCALMLLK 490
            |||.:|..|||..:.     :.||     ...|.|...:     |||::.....||.:.      
Mouse   159 TALDLADPSAKAVLTGDYKKDELL-----ESARSGNEEKMMALLTPLNVNCHASDGRKS------ 212

  Fly   491 SGASPNLTTDDCLTPVHVAARHGNLATLMQLLEDEGDPLYKSNTGE-TPLHMACRACHPDIVRHL 554
                         ||:|:||.: |...::|||...|..::..:.|: .|||.||...|.::...|
Mouse   213 -------------TPLHLAAGY-NRVKIVQLLLHHGADVHAKDKGDLVPLHNACSYGHYEVTELL 263

  Fly   555 IETVKEKHGPDKATTYINSVNEDGATALHYTCQITKEEVKIPESDKQIVRMLLENGADVTL---Q 616
            :     |||     ..:|:::....|.||......:.||         ..:||..|||.||   .
Mouse   264 V-----KHG-----ACVNAMDLWQFTPLHEAASKNRIEV---------CSLLLSYGADPTLLNCH 309

  Fly   617 TKTALETA---------------FHYCAVAGNNDVL-------MEMISHMNPTDIQKAM------ 653
            .|:|::.|               ......|...||.       :||::..:|...:.|:      
Mouse   310 NKSAIDLAPTAQLKERLSYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAAS 374

  Fly   654 -------------------NRQSSVGWTPLLIACHRGHMELVNNLLANHARVDVFDTEGRSALHL 699
                               |.::....|||.:|....|.::|..::.:.|:|:..|:.|:::||.
Mouse   375 PYPKRKQICELLLRKGANTNEKTKEFLTPLHVASENAHNDVVEVVVKHEAKVNALDSLGQTSLHR 439

  Fly   700 AAERGYLHVCDALLTNKAFINSKSRVGRTALHL--------------------------AAMNGF 738
            ||..|:|..|..||:.....|..|..|.|||.:                          ||..|.
Mouse   440 AAHCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGASLGHSEADRQLLEAAKAGD 504

  Fly   739 THLVKFLIKDHNAVIDILTLRKQTPLHLAAASGQMEVCQLLLELGANIDATDDLGQKPIHVAAQN 803
            ...||.|....:.....:..|:.||||.||...::.|.:.||:.||::.|.|..|..|:|.|...
Mouse   505 VETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSY 569

  Fly   804 NYSEVAKLFLQQHPSLVNATSKDGNTCAHIAAMQGSVKVIEELMKFDRSGVISARNKLTDATPLQ 868
            .:.|||:| |.:|.::||                     :.:|.||               |||.
Mouse   570 GHYEVAEL-LVKHGAVVN---------------------VADLWKF---------------TPLH 597

  Fly   869 LAAEGGHADVVKALVRAGASCTEENKAGFTAVHLAAQNGHGQVLDVLKSTNSLRINSKKLGLTPL 933
            .||..|..::.|.|::.||..|::|:.|.|.:.| .::|...:.|:|:...:|...:||      
Mouse   598 EAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDL-VKDGDTDIQDLLRGDAALLDAAKK------ 655

  Fly   934 HVAAYYGQADTVRELLTSVPATVKSETPTGQSLFGDLGTESGMTPLHLAAFSGNENVVRLLLNSA 998
                  |....|::|  |.|..|......|:.          .|||||||               
Mouse   656 ------GCLARVKKL--SSPDNVNCRDTQGRH----------STPLHLAA--------------- 687

  Fly   999 GVQVDAATIENGYNPLHLACFGGHMSVVGLLLSRSAELLQSQDRNGRTGLHIAAMHGHIQMVEIL 1063
                       |||.|.:|.:         ||...|: :.:||:.|...||.||.:||:.:..:|
Mouse   688 -----------GYNNLEVAEY---------LLQHGAD-VNAQDKGGLIPLHNAASYGHVDVAALL 731

  Fly  1064 LGQGAEINATDRNGWTPLHCAAKAGHLEVVKLLCEAGASPKSETNYGCAAIWFAASEGHNEVLRY 1128
            :...|.:||||:..:||||.||:.|..::..||...||.|..:...|...:...:::..:.:|..
Mouse   732 IKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTA 796

  Fly  1129 LMNKEHDTYGLMEDKRFVYNLMVVSKNHNNKPIQEFVL---VSPAPVDTAAKLSNIYIVLSTKEK 1190
            .|..        ......|...|:|.........:.:.   .||:.:..|:.|.|:         
Mouse   797 AMPP--------SALPTCYKPQVLSGVRGPGATADALSSGPSSPSSLSAASSLDNL--------- 844

  Fly  1191 ERAKDLVAAGKQCEAMATELLALAAGSDSAGKI-LQATDKRNVEF-------------------- 1234
                         ....:||.|:.:.|.:.|.. ||..:...::|                    
Mouse   845 -------------SGSFSELSAVVSSSAAEGATGLQRKEDSGIDFSITQFIRNLGLEHLMDIFER 896

  Fly  1235 ----LDVLIENEQKEV 1246
                ||||:|...||:
Mouse   897 EQITLDVLVEMGHKEL 912

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nompCNP_523483.2 ANK repeat 129..157 CDD:293786
Ank_2 131..228 CDD:289560
ANK 155..319 CDD:238125 23/77 (30%)
ANK repeat 159..186 CDD:293786
ANK repeat 232..265 CDD:293786 5/21 (24%)
Ank_2 237..331 CDD:289560 25/89 (28%)
ANK 263..387 CDD:238125 33/125 (26%)
ANK repeat 267..298 CDD:293786 10/32 (31%)
ANK repeat 300..331 CDD:293786 9/30 (30%)
Ank_2 305..398 CDD:289560 20/92 (22%)
ANK 329..454 CDD:238125 30/129 (23%)
ANK repeat 367..398 CDD:293786 4/30 (13%)
ANK repeat 400..431 CDD:293786 8/30 (27%)
Ank_2 405..498 CDD:289560 25/102 (25%)
ANK 428..555 CDD:238125 34/137 (25%)
ANK repeat 433..463 CDD:293786 10/34 (29%)
ANK repeat 469..499 CDD:293786 5/34 (15%)
ANK 496..641 CDD:238125 41/170 (24%)
ANK repeat 501..532 CDD:293786 10/30 (33%)
Ank_2 507..616 CDD:289560 32/112 (29%)
ANK repeat 534..575 CDD:293786 12/41 (29%)
ANK repeat 577..616 CDD:293786 12/41 (29%)
Ank_2 625..722 CDD:289560 28/128 (22%)
ANK 654..780 CDD:238125 40/151 (26%)
ANK repeat 660..690 CDD:293786 8/29 (28%)
ANK repeat 692..723 CDD:293786 11/30 (37%)
Ank_2 697..790 CDD:289560 34/118 (29%)
ANK 720..847 CDD:238125 38/152 (25%)
ANK repeat 725..757 CDD:293786 10/57 (18%)
ANK repeat 759..790 CDD:293786 13/30 (43%)
Ank_5 779..834 CDD:290568 18/54 (33%)
ANK 787..915 CDD:238125 34/127 (27%)
ANK repeat 792..824 CDD:293786 12/31 (39%)
ANK repeat 861..893 CDD:293786 11/31 (35%)
Ank_4 865..915 CDD:290365 17/49 (35%)
Ank_4 929..995 CDD:290365 14/65 (22%)
ANK repeat 932..972 CDD:293786 7/39 (18%)
ANK 969..1096 CDD:238125 37/126 (29%)
ANK repeat 974..1007 CDD:293786 7/32 (22%)
Ank_2 979..1074 CDD:289560 26/94 (28%)
ANK repeat 1009..1041 CDD:293786 8/31 (26%)
ANK 1039..1159 CDD:238125 33/119 (28%)
ANK repeat 1043..1074 CDD:293786 11/30 (37%)
Ank_2 1048..1135 CDD:289560 27/86 (31%)
ANK repeat 1076..1101 CDD:293786 9/24 (38%)
ANK repeat 1109..1134 CDD:293786 3/24 (13%)
Ion_trans <1393..1598 CDD:278921
Tnks2NP_001157107.1 ANK 1 23..52 8/32 (25%)
Ank_4 28..78 CDD:290365 19/50 (38%)
ANK 50..164 CDD:238125 38/148 (26%)
ANK 2 57..86 9/28 (32%)
ANK repeat 60..88 CDD:293786 9/27 (33%)
Ank_2 62..154 CDD:289560 29/125 (23%)
ANK repeat 90..121 CDD:293786 12/57 (21%)
ANK 3 90..119 11/45 (24%)
ANK repeat 123..154 CDD:293786 9/37 (24%)
ANK 4 123..152 9/35 (26%)
ANK 203..317 CDD:238125 38/152 (25%)
ANK 5 210..239 10/48 (21%)
ANK repeat 213..241 CDD:293786 10/28 (36%)
Ank_2 215..307 CDD:289560 32/111 (29%)
ANK repeat 243..274 CDD:293786 12/40 (30%)
ANK 6 243..272 11/38 (29%)
ANK repeat 276..307 CDD:293786 12/39 (31%)
ANK 7 276..305 10/37 (27%)
ANK 8 363..395 1/31 (3%)
ANK repeat 365..397 CDD:293786 2/31 (6%)
Ank_2 368..461 CDD:289560 20/92 (22%)
ANK 394..579 CDD:238125 54/185 (29%)
ANK repeat 399..430 CDD:293786 8/30 (27%)
ANK 9 399..428 8/28 (29%)
ANK 10 432..461 10/28 (36%)
ANK repeat 433..521 CDD:293786 22/87 (25%)
Ank_2 437..556 CDD:289560 34/118 (29%)
ANK 11 463..489 5/25 (20%)
ANK 518..643 CDD:238125 46/162 (28%)
ANK 12 525..554 12/28 (43%)
ANK repeat 528..556 CDD:293786 12/27 (44%)
Ank_2 530..622 CDD:289560 37/128 (29%)
HIF1AN-binding. /evidence=ECO:0000250|UniProtKB:Q9H2K2 545..553 4/7 (57%)
ANK repeat 558..589 CDD:293786 12/52 (23%)
ANK 13 558..587 12/50 (24%)
ANK repeat 591..622 CDD:293786 13/45 (29%)
ANK 14 591..620 12/43 (28%)
ANK 15 624..652 7/28 (25%)
ANK repeat 644..674 CDD:293786 9/43 (21%)
ANK 671..787 CDD:238125 44/161 (27%)
ANK 16 678..707 15/74 (20%)
ANK repeat 681..709 CDD:293786 15/63 (24%)
Ank_2 683..775 CDD:289560 40/127 (31%)
ANK repeat 711..742 CDD:293786 11/30 (37%)
ANK 17 711..740 9/28 (32%)
ANK repeat 744..775 CDD:293786 12/30 (40%)
ANK 18 744..773 12/28 (43%)
SAM_tankyrase1,2 871..936 CDD:188923 8/42 (19%)
SAM 877..933 CDD:197735 7/36 (19%)
tankyrase_like 938..1160 CDD:238718
PARP 952..1155 CDD:279038
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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