DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nompC and TRPC4

DIOPT Version :9

Sequence 1:	NP_523483.2	Gene:	nompC / 33768	FlyBaseID:	FBgn0016920	Length:	1761	Species:	Drosophila melanogaster
Sequence 2:	NP_003297.1	Gene:	TRPC4 / 7223	HGNCID:	12336	Length:	982	Species:	Homo sapiens

Alignment Length:	747	Identity:	179/747 - (23%)
Similarity:	287/747 - (38%)	Gaps:	187/747 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   975 GMTPLHLAAFSGNENVVRLLLNSAGVQVDAATIENGYNPLHLACFGGHMSVVGLLLSRSAELLQS 1039
            |.|.|.:|..:.|..::.||| |..|.|..|.       ||..    ...|||     :.|||.:
Human    70 GRTALLIAIENENLELIELLL-SFNVYVGDAL-------LHAI----RKEVVG-----AVELLLN 117

  Fly  1040 QDRNGRTGLHIAAMHGHIQMVEILLGQGAEINATDRNGWTPLHCAAKAGHLEVVKLLCEAGASPK 1104
            ..:..          |..|:..|||.:.......|   .||:..||...:.|::|||.:.|.|..
Human   118 HKKPS----------GEKQVPPILLDKQFSEFTPD---ITPIILAAHTNNYEIIKLLVQKGVSVP 169

  Fly  1105 SETNYGCAAIWFAASEGHNEVLRYLMNKEHDTYGLMEDKRFVYNLMVVSKNHNNKPIQEF-VLVS 1168
            ......|..:...:|..                             |.|..|:...:..: .|.|
Human   170 RPHEVRCNCVECVSSSD-----------------------------VDSLRHSRSRLNIYKALAS 205

  Fly  1169 PA--------PVDTAAKLSNIYIVLSTKEKERAKDLVAAGKQCEAMATELLALAAGSDSAGKILQ 1225
            |:        |..||.:||.....||..|.|...:.....:||:..|.:||.....|.....||.
Human   206 PSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILN 270

  Fly  1226 ATDK---------RNVEFLDVLIENEQKEVIAHTVVQRYLQELWHGSLT------WA-----SWK 1270
            ..|.         .::..|.:.|:..|||.:|....|:.|...|:....      ||     .:.
Human   271 YRDDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFI 335

  Fly  1271 ILLLLVAFIVCPPVWIGFTFPMGHKFNKVPIIKFM----SYLTSHIYLMI---HLSIVGITPIYP 1328
            |.||...|.||  ..|....|:| .|.:.|.|||:    ||||....|::   |:....:.
Human   336 IGLLFPVFSVC--YLIAPKSPLG-LFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLN---- 393

  Fly  1329 VLRLSLVPYWYEVGLLIWLSGLLLFELTNPSDKSGL--------GSIKVLVLLLGMAGVGVHVSA 1385
              |....|...|..:|.|:.|.:..|:....| .||        ..:..::..|.:|.:.:.:.|
Human   394 --RQGPPPTIVEWMILPWVLGFIWGEIKQMWD-GGLQDYIHDWWNLMDFVMNSLYLATISLKIVA 455

  Fly  1386 FLFVS----KEYW----PTLVYCRNQCFALAFLLACVQILDFLSFHHLFGPWAIIIGDLLKDLAR 1442
            |:..|    :|.|    ||||  ....||:|.:.:.::::...:.:...||..|.:|.:|.|:.:
Human   456 FVKYSALNPRESWDMWHPTLV--AEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILK 518

  Fly  1443 FLAVLAIFVFGFSMHIVALNQSFANFSPEDLRSF-------EKKNRNRGYFSDDDMPTPRPPPVE 1500
            ||.:..:.:..|:.   .|||.:  |..|:.:..       ||:|
Human   519 FLFIYCLVLLAFAN---GLNQLY--FYYEETKGLTCKGIRCEKQN-------------------- 558

  Fly  1501 NYVDSRFSEFRRKHKDDLRMHPINSFELLFFAVFGQTTTEQTQVDKIKNVATPTQPYWVEYLFKI 1565
                :.||..            ..:.:.||:::||......|.|        ..|..:.|::...
Human   559 ----NAFSTL------------FETLQSLFWSIFGLINLYVTNV--------KAQHEFTEFVGAT 599

  Fly  1566 VFGIYMLVSVVVLINLLIAMMSDTYQRIQAQSDIEWKFGLSKL-IRNMHRTTTAPSPLNLV---- 1625
            :||.|.::|:|||:|:|||||:::||.|...:||||||..:|| :.......|.|:|.|::
Human   600 MFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPK 664

  Fly  1626 TTWFM--WIVEKVKARMKKKKRPSLVQMMGIR 1655
            :.|::  ||...: .:.|.:::|.....:|:|
Human   665 SLWYLIKWIWTHL-CKKKMRRKPESFGTIGVR 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nompC	NP_523483.2	ANK repeat	129..157	CDD:293786
		Ank_2	131..228	CDD:289560
		ANK	155..319	CDD:238125
		ANK repeat	159..186	CDD:293786
		ANK repeat	232..265	CDD:293786
		Ank_2	237..331	CDD:289560
		ANK	263..387	CDD:238125
		ANK repeat	267..298	CDD:293786
		ANK repeat	300..331	CDD:293786
		Ank_2	305..398	CDD:289560
		ANK	329..454	CDD:238125
		ANK repeat	367..398	CDD:293786
		ANK repeat	400..431	CDD:293786
		Ank_2	405..498	CDD:289560
		ANK	428..555	CDD:238125
		ANK repeat	433..463	CDD:293786
		ANK repeat	469..499	CDD:293786
		ANK	496..641	CDD:238125
		ANK repeat	501..532	CDD:293786
		Ank_2	507..616	CDD:289560
		ANK repeat	534..575	CDD:293786
		ANK repeat	577..616	CDD:293786
		Ank_2	625..722	CDD:289560
		ANK	654..780	CDD:238125
		ANK repeat	660..690	CDD:293786
		ANK repeat	692..723	CDD:293786
		Ank_2	697..790	CDD:289560
		ANK	720..847	CDD:238125
		ANK repeat	725..757	CDD:293786
		ANK repeat	759..790	CDD:293786
		Ank_5	779..834	CDD:290568
		ANK	787..915	CDD:238125
		ANK repeat	792..824	CDD:293786
		ANK repeat	861..893	CDD:293786
		Ank_4	865..915	CDD:290365
		Ank_4	929..995	CDD:290365	6/19 (32%)
		ANK repeat	932..972	CDD:293786
		ANK	969..1096	CDD:238125	32/120 (27%)
		ANK repeat	974..1007	CDD:293786	12/31 (39%)
		Ank_2	979..1074	CDD:289560	23/94 (24%)
		ANK repeat	1009..1041	CDD:293786	8/31 (26%)
		ANK	1039..1159	CDD:238125	21/119 (18%)
		ANK repeat	1043..1074	CDD:293786	5/30 (17%)
		Ank_2	1048..1135	CDD:289560	18/86 (21%)
		ANK repeat	1076..1101	CDD:293786	8/24 (33%)
		ANK repeat	1109..1134	CDD:293786	2/24 (8%)
		Ion_trans	<1393..1598	CDD:278921	51/215 (24%)
TRPC4	NP_003297.1	trp	17..754	CDD:273311	179/747 (24%)
		ANK 1	31..60
		ANK 2	69..97		10/27 (37%)
		Multimerization domain. /evidence=ECO:0000250	87..172		31/114 (27%)
		ANK repeat	122..167	CDD:293786	15/57 (26%)
		Multimerization domain. /evidence=ECO:0000250	254..304		12/49 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..795
		PDZ-binding domain	980..982
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3609
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810