DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nompC and HACE1

DIOPT Version :9

Sequence 1:	NP_523483.2	Gene:	nompC / 33768	FlyBaseID:	FBgn0016920	Length:	1761	Species:	Drosophila melanogaster
Sequence 2:	NP_065822.2	Gene:	HACE1 / 57531	HGNCID:	21033	Length:	909	Species:	Homo sapiens

Alignment Length:	1182	Identity:	213/1182 - (18%)
Similarity:	367/1182 - (31%)	Gaps:	434/1182 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   421 LQKGEKVDVTTNDN----YTALHIAVESAKPAVVETLLGFGADVHVRGGKLRETPLHIAARVKDG 481
            |::...|:: ..||    ||.:.:.:.....:|.|.|.....||:...|:::.:.|||||.....
Human    15 LRRARTVEL-PEDNETAVYTLMPMVMADQHRSVSELLSNSKFDVNYAFGRVKRSLLHIAANCGSV 78

  Fly   482 DRCALMLLKSGASPNLTTDDCLTPVHVAARHGNLATLMQLLEDEGDPLYKSNTGETPLHMACRAC 546
            : |.::|||.||:||.......||:|:|||:|....:.:|||...|
Human    79 E-CLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSAD------------------- 123

  Fly   547 HPDIVRHLIETVKEKHGPDKATTYINSVNEDGATALHYTCQITKEEVKIPESDKQIVRMLLENGA 611
                                    :|..|.:|.||:
Human   124 ------------------------VNICNNEGLTAI----------------------------- 135

  Fly   612 DVTLQTKTALETAFHYCAVAGNNDVLMEMISHMNPTDIQKAMNRQSSVGWTPLLIACHRGHMELV 676
                          |:.||.|..::|.:::.|::..|::.||      |.|.|.:||..||...|
Human   136 --------------HWLAVNGRTELLHDLVQHVSDVDVEDAM------GQTALHVACQNGHKTTV 180

  Fly   677 NNLLANHARVDVFDTEGRSALHLAAERGYLHVCDALLTNKAFINSKSRVGRTALHLAAMNGFTHL 741
            ..||.:.|.::..:..|.:.|:.|...|.......||...|
Human   181 QCLLDSGADINRPNVSGATPLYFACSHGQRDTAQILLLRGA------------------------ 221

  Fly   742 VKFLIKDHNAVIDILTLRKQTPLHLAAASGQMEVCQLL-----------LELGANIDATDDLGQK 795
             |:| .|.|.|         |||.|....|..|.|::|           :::..|.|..:::.::
Human   222 -KYL-PDKNGV---------TPLDLCVQGGYGETCEVLIQYHPRLFQTIIQMTQNEDLRENMLRQ 275

  Fly   796 PIHVAAQNNYSEVAKLFLQQHPSLVNATSKDGNTCAHI-----AAMQGSVKVIEELMKFDRSGVI 855
            .:...:|.:.|:..|:.    .||....:.:|:....:     |.|:..::::.......|.|..
Human   276 VLEHLSQQSESQYLKIL----TSLAEVATTNGHKLLSLSSNYDAQMKSLLRIVRMFCHVFRIGPS 336

  Fly   856 SARNKLT-----DATPLQLAAEGGHADVVKALVRAGASCTE----------ENKAGFTAVHLAAQ 905
            |..|.:.     :.||        .:.|.|.|.....|..|          :||...|.:.....
Human   337 SPSNGIDMGYNGNKTP--------RSQVFKPLELLWHSLDEWLVLIATELMKNKRDSTEITSILL 393

  Fly   906 NGHGQVLDVLKSTNSLRINSKKLGLTPLHVAAYYGQADTVRELLTSVPATVKSETPTGQSLFGDL 970
            ...||..|.                                       |::....|.|...:.:|
Human   394 KQKGQDQDA---------------------------------------ASIPPFEPPGPGSYENL 419

  Fly   971 GT---ESGMTPLHLA----AFSGNENVVRLLLNSAGVQVDAATIENGYNPLHLACFGGHMSVVGL 1028
            .|   ||  .|..||    |.:..::|:.:..|.....:.|         .::.|  ......|:
Human   420 STGTRES--KPDALAGRQEASADCQDVISMTANRLSAVIQA---------FYMCC--SCQMPPGM 471

  Fly  1029 LLSRSAELLQSQD--------RNGRTGLHIAAMHGHI---------QMVEILLGQGAEINATDRN 1076
            ...|..|.:...|        ||.:    |...|.|.         :.:.|:..|..:    ||.
Human   472 TSPRFIEFVCKHDEVLKCFVNRNPK----IIFDHFHFLLECPELMSRFMHIIKAQPFK----DRC 528

  Fly  1077 GW--TPLHCAAKAGHL----------------EVVKLLCEAGASPKSETNYGCA------AIWFA 1117
            .|  ..||.......:                .:.:..||.    .|:.|  ||      |:.|.
Human   529 EWFYEHLHSGQPDSDMVHRPVNENDILLVHRDSIFRSSCEV----VSKAN--CAKLKQGIAVRFH 587

  Fly  1118 ASEG-------------HNEVLR--YLM------------------NKEHDTYGLMEDKRFVYNL 1149
            ..||             .||::.  |.:                  |.:|..|     .||...:
Human   588 GEEGMGQGVVREWFDILSNEIVNPDYALFTQSADGTTFQPNSNSYVNPDHLNY-----FRFAGQI 647

  Fly  1150 MVVSKNHN-------NKPIQEFVLVSPAPVDTAAKL-----SNIYIVLSTKEKERAKDLVAAGKQ 1202
            :.::.||.       .:...:.:|..|......|.:     .|:..:|.....:...:|..:.:.
Human   648 LGLALNHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVET 712

  Fly  1203 CEAMATELLALAAGSDSAGKILQATDKRNVEFLDVLIENEQKEVIA----------HTVVQRYLQ 1257
            ....|.|.:.|..|   .|.|| .|.....|::.::.|......|.          |..:...|.
Human   713 DVFGAMEEVPLKPG---GGSIL-VTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLI 773

  Fly  1258 ELWHGSLTWASWKILLLLVAFIVCPPV----WIGFT-FPMGHKFNKVPIIKFMSYLTSHIYLMIH 1317
            :|:.      .:::.|||...   |.:    ||..| :..|:: .:.|:|::
Human   774 QLFD------EYELELLLSGM---PEIDVSDWIKNTEYTSGYE-REDPVIQW------------- 815

  Fly  1318 LSIVGITPIYPVLRLSLVPYWYEVGLLIWLSGLLLFELTNPSDK---SGLGSIKVLVLLLGMAGV 1379
                               :|..|..:.....:||.:....|.:   .|..:|        |.|.
Human   816 -------------------FWEVVEDITQEERVLLLQFVTGSSRVPHGGFANI--------MGGS 853

  Fly  1380 GVHVSAFLFVSKEYWPTLVYCRNQCFALAFLLACVQILDFLSFHHLFGPWAIIIGDLLKDLARFL 1444
            |  :..|...:..|.|.|:...:.|..:      :::.::.|            .::|||  |.|
Human   854 G--LQNFTIAAVPYTPNLLPTSSTCINM------LKLPEYPS------------KEILKD--RLL 896

  Fly  1445 AVLAIFVFGFSM 1456
            ..|....:|::|
Human   897 VALHCGSYGYTM 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nompC	NP_523483.2	ANK repeat	129..157	CDD:293786
		Ank_2	131..228	CDD:289560
		ANK	155..319	CDD:238125
		ANK repeat	159..186	CDD:293786
		ANK repeat	232..265	CDD:293786
		Ank_2	237..331	CDD:289560
		ANK	263..387	CDD:238125
		ANK repeat	267..298	CDD:293786
		ANK repeat	300..331	CDD:293786
		Ank_2	305..398	CDD:289560
		ANK	329..454	CDD:238125	8/36 (22%)
		ANK repeat	367..398	CDD:293786
		ANK repeat	400..431	CDD:293786	2/9 (22%)
		Ank_2	405..498	CDD:289560	25/80 (31%)
		ANK	428..555	CDD:238125	34/130 (26%)
		ANK repeat	433..463	CDD:293786	9/33 (27%)
		ANK repeat	469..499	CDD:293786	13/29 (45%)
		ANK	496..641	CDD:238125	22/144 (15%)
		ANK repeat	501..532	CDD:293786	11/30 (37%)
		Ank_2	507..616	CDD:289560	14/108 (13%)
		ANK repeat	534..575	CDD:293786	1/40 (3%)
		ANK repeat	577..616	CDD:293786	3/38 (8%)
		Ank_2	625..722	CDD:289560	27/96 (28%)
		ANK	654..780	CDD:238125	31/136 (23%)
		ANK repeat	660..690	CDD:293786	11/29 (38%)
		ANK repeat	692..723	CDD:293786	7/30 (23%)
		Ank_2	697..790	CDD:289560	21/103 (20%)
		ANK	720..847	CDD:238125	23/142 (16%)
		ANK repeat	725..757	CDD:293786	5/31 (16%)
		ANK repeat	759..790	CDD:293786	10/41 (24%)
		Ank_5	779..834	CDD:290568	9/70 (13%)
		ANK	787..915	CDD:238125	26/147 (18%)
		ANK repeat	792..824	CDD:293786	5/31 (16%)
		ANK repeat	861..893	CDD:293786	7/46 (15%)
		Ank_4	865..915	CDD:290365	13/59 (22%)
		Ank_4	929..995	CDD:290365	12/72 (17%)
		ANK repeat	932..972	CDD:293786	4/39 (10%)
		ANK	969..1096	CDD:238125	28/168 (17%)
		ANK repeat	974..1007	CDD:293786	8/36 (22%)
		Ank_2	979..1074	CDD:289560	18/115 (16%)
		ANK repeat	1009..1041	CDD:293786	4/31 (13%)
		ANK	1039..1159	CDD:238125	33/200 (17%)
		ANK repeat	1043..1074	CDD:293786	6/39 (15%)
		Ank_2	1048..1135	CDD:289560	24/152 (16%)
		ANK repeat	1076..1101	CDD:293786	5/42 (12%)
		ANK repeat	1109..1134	CDD:293786	10/63 (16%)
		Ion_trans	<1393..1598	CDD:278921	13/64 (20%)
HACE1	NP_065822.2	Ank_2	<27..>283	CDD:330894	80/383 (21%)
		ANK 1	64..93		12/29 (41%)
		ANK repeat	66..95	CDD:293786	13/29 (45%)
		ANK	92..217	CDD:238125	41/216 (19%)
		ANK repeat	97..128	CDD:293786	12/73 (16%)
		ANK 2	97..126		11/71 (15%)
		ANK repeat	130..161	CDD:293786	10/73 (14%)
		ANK 3	130..159		9/71 (13%)
		ANK repeat	163..194	CDD:293786	12/36 (33%)
		ANK 4	163..192		12/34 (35%)
		ANK 5	196..226		9/55 (16%)
		ANK repeat	196..221	CDD:293786	6/24 (25%)
		ANK 6	228..257		10/37 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..433		11/75 (15%)
		HECTc	554..903	CDD:238033	72/435 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810