DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nompC and ankrd67

DIOPT Version :9

Sequence 1:	NP_523483.2	Gene:	nompC / 33768	FlyBaseID:	FBgn0016920	Length:	1761	Species:	Drosophila melanogaster
Sequence 2:	NP_001122202.1	Gene:	ankrd67 / 566073	ZFINID:	ZDB-GENE-050419-160	Length:	422	Species:	Danio rerio

Alignment Length:	451	Identity:	123/451 - (27%)
Similarity:	191/451 - (42%)	Gaps:	100/451 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   697 LHLAAERGYLHVCDALLTNKAFINSKSRVGRTALHLAAMNGFTHLVKFLIKDHNAVIDILTLRKQ 761
            ||.||..|.|....|:|......|.:...|.||:|.|:..|...|:|||::.....::.......
Zfish    55 LHYAAWDGCLEQVKAMLERGVPANCQDPYGWTAVHHASFKGHLMLIKFLLQTGQVEVNNQDFFNC 119

  Fly   762 TPLHLAAASGQMEVCQLLLELGANIDATDDLGQKPIHVAAQNNYSEVAKLFLQQHPSLVNATSKD 826
            |.||.:.:.|..|...|||:.||:.......||.|:|:||.:.:...|::.||.   |.:...:|
Zfish   120 TALHRSCSGGNPETTDLLLQKGASHSTRSCSGQTPLHLAAASGHLGTARVLLQH---LASPNPQD 181

  Fly   827 GNTCAHIAAMQGSVKVIEELMKFDRSGVISARNKLTDATPLQLAAEGGHADVVKALVRAGASCTE 891
            .|..|                                  ||..|..||..||.:.|:..||.
Zfish   182 FNKWA----------------------------------PLHWAIFGGWGDVAELLLDNGAD--- 209

  Fly   892 ENKAGFTAVHLAAQNGHGQVLDVLKSTNSLRINSKKLGLTPLHVAAYYGQADTVRELLTSVPATV 956
                        .:.|.|                  :|::||.:|...|....|| ||....|..
Zfish   210 ------------VEGGKG------------------VGMSPLQLAVLVGNEAGVR-LLLQRGADA 243

  Fly   957 KSETPTGQSLFGDLGTESGMTPLHLAAFSGNENVVRLLLNSAGVQVDAATIENG--YNPLHLACF 1019
            ....|.|:            |.:||.|.||::.:::.|| :.|.:||   :.:|  .:|||||..
Zfish   244 NMRGPNGR------------TAMHLCACSGDKKILQQLL-AGGARVD---VRDGDVASPLHLAAR 292

  Fly  1020 GGHMSVVGLLLSRSAELLQSQDRNGRTGLHIAAMHGHIQMVEILLGQGAEINATDRNGWTPLHCA 1084
            .|..:||.||:...|. |:.:|....|.||.:.:..:|:..::||..||::||.:|.|.||||.|
Zfish   293 SGSRAVVHLLILNGAG-LEDRDNLKMTPLHYSTLRDNIEAAKLLLHYGADVNAVERLGQTPLHLA 356

  Fly  1085 AKAGHLEVVKLLCEAGASPKSETNYGCAAIWFAASE----GHNEVLRYLMNKEHDTYGLME 1141
            ::.||.:|:|:|.:.||.|...::      |...:|    .||::....:.::|.|..:.|
Zfish   357 SERGHCKVLKVLLDKGADPNLRSS------WRETAEDIARAHNQLAVIQLLQQHQTVSMRE 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nompC	NP_523483.2	ANK repeat	129..157	CDD:293786
		Ank_2	131..228	CDD:289560
		ANK	155..319	CDD:238125
		ANK repeat	159..186	CDD:293786
		ANK repeat	232..265	CDD:293786
		Ank_2	237..331	CDD:289560
		ANK	263..387	CDD:238125
		ANK repeat	267..298	CDD:293786
		ANK repeat	300..331	CDD:293786
		Ank_2	305..398	CDD:289560
		ANK	329..454	CDD:238125
		ANK repeat	367..398	CDD:293786
		ANK repeat	400..431	CDD:293786
		Ank_2	405..498	CDD:289560
		ANK	428..555	CDD:238125
		ANK repeat	433..463	CDD:293786
		ANK repeat	469..499	CDD:293786
		ANK	496..641	CDD:238125
		ANK repeat	501..532	CDD:293786
		Ank_2	507..616	CDD:289560
		ANK repeat	534..575	CDD:293786
		ANK repeat	577..616	CDD:293786
		Ank_2	625..722	CDD:289560	9/24 (38%)
		ANK	654..780	CDD:238125	25/82 (30%)
		ANK repeat	660..690	CDD:293786
		ANK repeat	692..723	CDD:293786	9/25 (36%)
		Ank_2	697..790	CDD:289560	29/92 (32%)
		ANK	720..847	CDD:238125	34/126 (27%)
		ANK repeat	725..757	CDD:293786	10/31 (32%)
		ANK repeat	759..790	CDD:293786	10/30 (33%)
		Ank_5	779..834	CDD:290568	17/54 (31%)
		ANK	787..915	CDD:238125	25/127 (20%)
		ANK repeat	792..824	CDD:293786	10/31 (32%)
		ANK repeat	861..893	CDD:293786	10/31 (32%)
		Ank_4	865..915	CDD:290365	12/49 (24%)
		Ank_4	929..995	CDD:290365	18/65 (28%)
		ANK repeat	932..972	CDD:293786	11/39 (28%)
		ANK	969..1096	CDD:238125	46/128 (36%)
		ANK repeat	974..1007	CDD:293786	11/32 (34%)
		Ank_2	979..1074	CDD:289560	34/96 (35%)
		ANK repeat	1009..1041	CDD:293786	13/33 (39%)
		ANK	1039..1159	CDD:238125	33/107 (31%)
		ANK repeat	1043..1074	CDD:293786	10/30 (33%)
		Ank_2	1048..1135	CDD:289560	28/90 (31%)
		ANK repeat	1076..1101	CDD:293786	11/24 (46%)
		ANK repeat	1109..1134	CDD:293786	4/28 (14%)
		Ion_trans	<1393..1598	CDD:278921
ankrd67	NP_001122202.1	Ank_4	55..104	CDD:290365	18/48 (38%)
		ANK repeat	55..81	CDD:293786	9/25 (36%)
		ANK	78..204	CDD:238125	41/162 (25%)
		ANK repeat	83..115	CDD:293786	10/31 (32%)
		Ank_2	89..181	CDD:289560	27/94 (29%)
		ANK repeat	119..148	CDD:293786	10/28 (36%)
		ANK repeat	150..181	CDD:293786	10/33 (30%)
		Ank_2	155..246	CDD:289560	32/161 (20%)
		ANK repeat	183..211	CDD:293786	12/76 (16%)
		ANK repeat	216..246	CDD:293786	10/30 (33%)
		ANK	217..245	CDD:197603	10/28 (36%)
		ANK	244..369	CDD:238125	48/141 (34%)
		ANK repeat	249..280	CDD:293786	12/46 (26%)
		Ank_4	250..303	CDD:290365	22/68 (32%)
		ANK repeat	285..313	CDD:293786	12/28 (43%)
		Ank_2	287..378	CDD:289560	37/91 (41%)
		ANK repeat	315..346	CDD:293786	10/30 (33%)
		ANK	343..>404	CDD:238125	21/66 (32%)
		ANK repeat	348..378	CDD:293786	14/29 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910