DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nompC and ankrd28b

DIOPT Version :9

Sequence 1:	NP_523483.2	Gene:	nompC / 33768	FlyBaseID:	FBgn0016920	Length:	1761	Species:	Drosophila melanogaster
Sequence 2:	XP_009290540.1	Gene:	ankrd28b / 560747	ZFINID:	ZDB-GENE-070622-4	Length:	1052	Species:	Danio rerio

Alignment Length:	1064	Identity:	300/1064 - (28%)
Similarity:	475/1064 - (44%)	Gaps:	106/1064 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 EDGNHIPLAGVHDMNTGMTPLMYATKDNKTAIMDRMIELGADVGARNNDNYNVLHIAAMYSREDV 175
            ||.|      |.| |...|||..|.......|::.:|..||.|.|::|.....||.|.....|:.
Zfish    32 EDVN------VQD-NEKRTPLHAAAYLGDAEIIELLILSGARVNAKDNKWLTPLHRAVASCSEEA 89

  Fly   176 VKLLLTKRGVDPFSTGGSRSQTAVHLVSSRQTGTATNILRALLAAAGKDIRLKADGRGKIPLLLA 240
            |::|| |...| .:......||.:|:.::.:.......|..||:...     .:|..|:..|..|
Zfish    90 VQVLL-KHSAD-VNARDKNWQTPLHVAAANKAVRCAEALVPLLSNVN-----VSDRAGRTALHHA 147

  Fly   241 VESGNQSMCRELLAAQTAEQLKATTANGDTALHLAARRRDVDMVRILVDYGTNVDTQNGEGQTPL 305
            ..||:..|.|.||:  ....:.|.......|:|.||....:::|::||.:|..|..::.:..|||
Zfish   148 AFSGHLEMVRLLLS--RGANINAFDKKDRRAIHWAAYMGHMEVVKLLVSHGAEVPCKDKKAYTPL 210

  Fly   306 HIAAAEGDEALLKYFYGVRASASIADNQDRTPMHLAAENGHAHVIEILADKFKASIFERTKDGST 370
            |.||:.|..:::||...:....:..:....||:|:|..||...|:..|.: ..|::.:..:.|..
Zfish   211 HAAASSGMISVVKYLLDMGVDMNEPNAYGNTPLHVACYNGQDVVVNELIE-CGANVNQVNEKGFA 274

  Fly   371 LMHIASLNGH-AECATMLFKKGVYLHMPNKDGARSIHTAAAYGHTGIINTLLQKGEKVDVTTNDN 434
            .:|..:.:.| |.|..:|...|..:::.:|||...:|..|.:|.......::|.|.::|....:.
Zfish   275 PLHFTAASRHGALCLELLVGNGADVNIKSKDGKTPLHMTAIHGRFSRSQAIIQNGAEIDCEDKNG 339

  Fly   435 YTALHIAVESAKPAVVETLLGFGADVHVRG--GKLRETPLHIAARVKDGDRCALMLLKSGASPNL 497
            .|.||||.......::.||:..|||...||  |..   |||:||.....| |...||.||...:.
Zfish   340 NTPLHIAARYGHELLINTLITNGADTAKRGVHGMF---PLHLAALSGFSD-CCRKLLSSGFDIDT 400

  Fly   498 TTDDCLTPVHVAARHGNLATLMQLLEDEGDPLYKSNTGETPLHMACRACHPDIVRHLIETVKEKH 562
            ..|...|.:|.||..|||..|..||....|...|.:.|.||||.|...|:...:..|:.:
Zfish   401 PDDFGRTCLHAAAAGGNLECLNLLLNTGADFNRKDSFGRTPLHYAAANCNYQCLFALVGS----- 460

  Fly   563 GPDKATTYINSVNEDGATALHYTCQITKEEVKIPESDKQIVRMLLENGADVTLQTKTALETAFHY 627
            |.:     :|.:::.|.|.|||..        ..::|.:.:..||.|.|:..::..... .|.||
Zfish   461 GAN-----VNELDKRGCTPLHYAA--------ASDADGKCLEYLLRNDANPGIRDNQGY-NAVHY 511

  Fly   628 CAVAGNN------------DVLMEMISHMNPTDIQKAMNRQSSVGWTPLLIACHRGHMELVNNLL 680
            .:..|:.            |||||    .:.|||....:..:.|  :||.:|.:.||.:.:..|:
Zfish   512 ASAYGHRLCLELIASETPLDVLME----TSGTDILNDSDVLAPV--SPLHLAAYHGHHQALEVLV 570

  Fly   681 ANHARVDVFDTEGRSALHLAAERGYLHVCDALLTNKAFINSKS-RVGRTALHLAAMNGFTHLVKF 744
            .:...:||...:|.:.|.|||.:|::...|.|:...|.|..|. .:.||.:|.||.||.:..::.
Zfish   571 QSLLDLDVRTAQGHTPLDLAAFKGHVECVDVLINQGASILVKDYTLKRTPIHAAATNGHSECLRL 635

  Fly   745 LI--KDHNAVIDILTLRKQTPLHLAAASGQMEVCQLLLELGANIDATDDLGQKPIHVAAQNNYSE 807
            ||  .|..:.:||.....||||.|:...|..:....|:..|||:||.|..|:..:|..|...:.|
Zfish   636 LIGNADLQSAVDIQDGIGQTPLMLSVLGGHTDCVYSLINKGANVDAKDKWGRTALHRGAVTGHEE 700

  Fly   808 VAKLFLQQHPSLVNATSKDGNTCAHIAAMQGSVKVIEELMKFDRSGVISARNKLTD---ATPLQL 869
            ..:..||...|.:....: |.:..|:|:..|.|.|:..|:...:|  :.:...:||   .|||..
Zfish   701 CVEALLQHSASFMVRDCR-GRSPVHLASACGHVGVLGGLLHAAQS--VESIPVITDHQGYTPLHW 762

  Fly   870 AAEGGHADVVKALVRAGA-SCTEENKAGFTAVHLAAQNGHGQVLDVLKSTNS---LRINSKKLGL 930
            |...||...|:.|:.... ..||.|.  |:.:|.|..|.:...:::|..|.|   :..|..| ..
Zfish   763 ACYNGHDTCVEVLLEQELFHKTEGNP--FSPLHCAVINDNEGAVELLIETLSPVIVNANDSK-NR 824

  Fly   931 TPLHVAAYYGQADTVRELLTSVPATVKSETPTGQSLFGDLGTESGMTPLHLAAFSGNENVVRLLL 995
            ||||.||:....:.::.||             |.:...:.....|.|||.:||.:|..|.|.:|:
Zfish   825 TPLHAAAFTDHVECLQLLL-------------GHNAQVNCVDAGGKTPLMMAAENGQTNAVEVLV 876

  Fly   996 NSAGVQVDAATIE--NGYNPLHLACFGGHMSVVGLLLSRSAE--LLQSQDRNGRTGLHIAAMHGH 1056
            :||...:   |::  |....|||||..||.:...|:|.:..:  |:.|.:...:|.||:||.:|.
Zfish   877 SSAKADL---TLQDANKNTALHLACSKGHETSALLILEKITDRNLINSTNAALQTPLHVAARNGL 938

  Fly  1057 IQMVEILLGQGAEINATDRNGWTP-LHCAAKAGHLEVVKLLCEAGASPKSETNYGCAAIWFAASE 1120
            ..:|:.||.:||.:.|.|.||:|| |.||......:.:.|:. |...|.|........:.|:|..
Zfish   939 TVVVQELLAKGASVLAVDENGYTPALACAPNKDVADCLALIL-ATMMPVSPGGGSVPTLTFSAIN 1002

  Fly  1121 GHNEVLRY-------LMNKEHDTY 1137
            .:....:.       ::..||.:|
Zfish  1003 HYTSPTKSVTFDSLPMLRSEHSSY 1026

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nompC	NP_523483.2	ANK repeat	129..157	CDD:293786	10/27 (37%)
		Ank_2	131..228	CDD:289560	24/96 (25%)
		ANK	155..319	CDD:238125	44/163 (27%)
		ANK repeat	159..186	CDD:293786	8/26 (31%)
		ANK repeat	232..265	CDD:293786	10/32 (31%)
		Ank_2	237..331	CDD:289560	27/93 (29%)
		ANK	263..387	CDD:238125	33/124 (27%)
		ANK repeat	267..298	CDD:293786	9/30 (30%)
		ANK repeat	300..331	CDD:293786	9/30 (30%)
		Ank_2	305..398	CDD:289560	23/93 (25%)
		ANK	329..454	CDD:238125	31/125 (25%)
		ANK repeat	367..398	CDD:293786	7/31 (23%)
		ANK repeat	400..431	CDD:293786	8/30 (27%)
		Ank_2	405..498	CDD:289560	30/94 (32%)
		ANK	428..555	CDD:238125	45/128 (35%)
		ANK repeat	433..463	CDD:293786	10/29 (34%)
		ANK repeat	469..499	CDD:293786	11/29 (38%)
		ANK	496..641	CDD:238125	42/156 (27%)
		ANK repeat	501..532	CDD:293786	11/30 (37%)
		Ank_2	507..616	CDD:289560	31/108 (29%)
		ANK repeat	534..575	CDD:293786	10/40 (25%)
		ANK repeat	577..616	CDD:293786	10/38 (26%)
		Ank_2	625..722	CDD:289560	30/108 (28%)
		ANK	654..780	CDD:238125	38/128 (30%)
		ANK repeat	660..690	CDD:293786	8/29 (28%)
		ANK repeat	692..723	CDD:293786	10/30 (33%)
		Ank_2	697..790	CDD:289560	34/95 (36%)
		ANK	720..847	CDD:238125	39/129 (30%)
		ANK repeat	725..757	CDD:293786	12/33 (36%)
		ANK repeat	759..790	CDD:293786	12/30 (40%)
		Ank_5	779..834	CDD:290568	16/54 (30%)
		ANK	787..915	CDD:238125	35/131 (27%)
		ANK repeat	792..824	CDD:293786	7/31 (23%)
		ANK repeat	861..893	CDD:293786	12/35 (34%)
		Ank_4	865..915	CDD:290365	15/50 (30%)
		Ank_4	929..995	CDD:290365	18/65 (28%)
		ANK repeat	932..972	CDD:293786	8/39 (21%)
		ANK	969..1096	CDD:238125	45/131 (34%)
		ANK repeat	974..1007	CDD:293786	12/32 (38%)
		Ank_2	979..1074	CDD:289560	34/98 (35%)
		ANK repeat	1009..1041	CDD:293786	12/33 (36%)
		ANK	1039..1159	CDD:238125	30/107 (28%)
		ANK repeat	1043..1074	CDD:293786	12/30 (40%)
		Ank_2	1048..1135	CDD:289560	26/94 (28%)
		ANK repeat	1076..1101	CDD:293786	9/25 (36%)
		ANK repeat	1109..1134	CDD:293786	2/31 (6%)
		Ion_trans	<1393..1598	CDD:278921
ankrd28b	XP_009290540.1	ANK repeat	11..38	CDD:293786	4/11 (36%)
		Ank_2	12..104	CDD:289560	26/80 (33%)
		ANK repeat	40..71	CDD:293786	10/30 (33%)
		Ank	42..72	CDD:278452	10/29 (34%)
		ANK	68..193	CDD:238125	33/133 (25%)
		ANK repeat	76..104	CDD:293786	9/29 (31%)
		ANK repeat	106..137	CDD:293786	6/35 (17%)
		Ank_2	111..203	CDD:289560	24/98 (24%)
		ANK	134..259	CDD:238125	36/131 (27%)
		ANK repeat	140..170	CDD:293786	10/31 (32%)
		ANK repeat	172..203	CDD:293786	9/30 (30%)
		Ank_2	177..269	CDD:289560	26/92 (28%)
		ANK repeat	205..236	CDD:293786	9/30 (30%)
		ANK repeat	238..269	CDD:293786	9/31 (29%)
		Ank_5	258..312	CDD:290568	12/54 (22%)
		ANK repeat	271..302	CDD:293786	7/30 (23%)
		ANK	300..416	CDD:238125	38/119 (32%)
		ANK repeat	305..336	CDD:293786	8/30 (27%)
		Ank_2	310..402	CDD:289560	30/95 (32%)
		ANK repeat	338..363	CDD:293786	7/24 (29%)
		ANK repeat	371..402	CDD:293786	12/34 (35%)
		Ank_2	376..468	CDD:289560	33/102 (32%)
		ANK	399..524	CDD:238125	37/143 (26%)
		ANK repeat	404..435	CDD:293786	11/30 (37%)
		ANK repeat	437..468	CDD:293786	10/40 (25%)
		ANK repeat	470..502	CDD:293786	10/39 (26%)
		Ank_2	475..613	CDD:289560	39/152 (26%)
		ANK repeat	552..580	CDD:293786	8/27 (30%)
		ANK	577..706	CDD:238125	42/128 (33%)
		ANK repeat	583..613	CDD:293786	10/29 (34%)
		Ank_2	587..683	CDD:289560	34/95 (36%)
		ANK repeat	618..650	CDD:293786	12/31 (39%)
		ANK	647..776	CDD:238125	39/131 (30%)
		ANK repeat	652..683	CDD:293786	12/30 (40%)
		ANK repeat	685..710	CDD:293786	6/24 (25%)
		Ank_4	686..735	CDD:290365	12/49 (24%)
		ANK repeat	718..746	CDD:293786	8/30 (27%)
		Ank_4	756..808	CDD:290365	15/53 (28%)
		ANK repeat	787..820	CDD:293786	8/34 (24%)
		Ank_2	792..887	CDD:289560	30/111 (27%)
		ANK	817..946	CDD:238125	43/145 (30%)
		ANK repeat	824..853	CDD:293786	9/41 (22%)
		ANK repeat	855..887	CDD:293786	13/34 (38%)
		Ank_2	860..956	CDD:289560	34/98 (35%)
		ANK repeat	889..920	CDD:293786	11/30 (37%)
		ANK repeat	925..956	CDD:293786	12/30 (40%)
		Ank_2	930..>990	CDD:289560	23/60 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920