DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nompC and trpc2a

DIOPT Version :9

Sequence 1:	NP_523483.2	Gene:	nompC / 33768	FlyBaseID:	FBgn0016920	Length:	1761	Species:	Drosophila melanogaster
Sequence 2:	XP_017206723.1	Gene:	trpc2a / 559914	ZFINID:	ZDB-GENE-130530-602	Length:	855	Species:	Danio rerio

Alignment Length:	830	Identity:	181/830 - (21%)
Similarity:	318/830 - (38%)	Gaps:	245/830 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1014 LHLACFGGHMSVVGLLLSRS----AELLQSQDRNGRTGLHIAAMHGHIQ-MVEILLG-------- 1065
            |.||...|:|:.|..|||..    .:|.:|:||..|..|:::...|... |..:|||
Zfish    23 LILAIQEGNMAWVDSLLSLGDGIIRQLDESEDRLWREALNLSIRLGSEDIMTSLLLGVKFDFRQI 87

  Fly  1066 QGAEINATDRN-----------------------------------------GWTPLHCAAKAGH 1089
            ..|.:.|.|.|                                         |.|||..|.:...
Zfish    88 HEALLVAVDTNQPRFVKHLLDRLDLEKGNKMDVRSFSMAIFDHSIDDSQFAPGVTPLTLACQKDL 152

  Fly  1090 LEVVKLLCEAGASPKSETNYGCAAIWFAASEGHN-EVLRYLMNKEHDTYGLMEDKRFVYNLMVVS 1153
            .|:|.:|.:.|..........|..:  ..:.|.. ::|::.::: .:||..:..:.:   |.:.|
Zfish   153 YEIVMMLTQRGHDIPLPHAISCTCL--ECNNGRQYDLLKFSLSR-INTYRGIASRAY---LSITS 211

  Fly  1154 KN------HNNKPIQEFVLVSPAPVDTAAKLSNIYIVLSTKEKERAKDLVAAGKQCEAMATELLA 1212
            ::      |.:|.:::                     ||.||.|.....:|..:.|:..|.|||.
Zfish   212 EDAMLSAFHLSKELRK---------------------LSKKEPEFKPQYLALEELCQEFAVELLG 255

  Fly  1213 LAAGSDSAGKILQAT---------DKR-------NVEFLDVLIENEQKEVIAHTVVQRYLQELWH 1261
            :.........||.:.         |::       |:..|.:.:...||:.:.|.:.|:.|..:|.
Zfish   256 MCRNQSEVSTILNSAEGDSEDEELDEQTFEEGIPNLARLRLAVNYNQKQFVTHPICQQVLSSIWC 320

  Fly  1262 GSLT-W----ASWKILLLLVAFIVCPPV----WIGFTFPMGHKFNKVPIIKFMSYLTSHIYLMIH 1317
            |||: |    .:||:|:.|..|:..|.:    ||.....:| |..|||:|||:.:..|:::.:|.
Zfish   321 GSLSGWRGSRTTWKLLVSLGIFLTMPVLCLIYWIAPKSKLG-KLLKVPVIKFLLHSASYMWFLIA 384

  Fly  1318 LSIVGI-TPIY---------PVLRLSLVP------YWYEVGLLIWLSGL--LLFELTNPSDKSGL 1364
            |....| ..||         .:|..||..      :|:|. ..:|:.||  ...:|.|..|...|
Zfish   385 LLTESIFMEIYRTEFASRNQNILHNSLHMVWVAGFFWFEC-KEVWIEGLKSYFLDLWNILDMMVL 448

  Fly  1365 G------SIKVLVLLLGM-----AGVGVHVSAFLFVSKEYW----PTLVYCRNQCFALAFLLACV 1414
            .      ::::|::|.|.     :........|....:|.|    |.|:  ....||:..:|:..
Zfish   449 SMYLASFTLRILIMLKGYFLCQDSSTQELCDYFTNTVRENWRQEDPQLI--AETLFAVTSMLSFT 511

  Fly  1415 QILDFLSFHHLFGPWAIIIGDLLKDLARFLAVLAI----FVFG---------FSMHIVALNQSFA 1466
            ::...|..|...|...|.:|.::.|:.||:.:|.|    |:.|         .|.|:..||::|
Zfish   512 RLAYILPAHESLGTLQISMGRMIDDMMRFMFILMIIGTAFLCGINNIYVPYVISPHLGRLNETF- 575

  Fly  1467 NFSPEDLRSFEKKNRNRGYFSDDDMPTPRPPPVENYVDSRFSEFRRKHKDDLRMHPINSFELLFF 1531
            ||                                                            ||:
Zfish   576 NF------------------------------------------------------------LFW 580

  Fly  1532 AVFGQTTTEQTQVDKIKNVATPTQPYW--VEYLFKIVFGIYMLVSVVVLINLLIAMMSDTYQRIQ 1594
            .:||.  ..|..||         .|.:  .|::.:|.:||:.|:.|:||:|:||||:|:::|||:
Zfish   581 TMFGM--ANQGYVD---------MPDYALAEFVGRIFYGIFTLLIVIVLLNMLIAMISNSFQRIE 634

  Fly  1595 AQSDIEWKFGLSKLIRNMHRT-TTAPSPLNLVTT--WFMWIVEKVKARM---KKKKRPSLVQMMG 1653
            ..:|:||||..|||..:..|. .|.|.|.|::.:  .|.:|:..:..::   .:||.|....:..
Zfish   635 DDADVEWKFARSKLYLSYFREGLTMPVPFNIIPSPKAFFYILRGIFQKICCCCQKKAPEYPPITS 699

  Fly  1654 IRQASPRTKAGAKWLSKIK-KDSVALSQVHLSPLGSQASFSQANQNRIEN 1702
            : .::.....|.:...::. :..|..:.||.....::..|.::.:..:.|
Zfish   700 V-SSNAMNSGGGQGEGRVPYRLQVTKALVHRYIEAARREFEESTRKDVGN 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nompC	NP_523483.2	ANK repeat	129..157	CDD:293786
		Ank_2	131..228	CDD:289560
		ANK	155..319	CDD:238125
		ANK repeat	159..186	CDD:293786
		ANK repeat	232..265	CDD:293786
		Ank_2	237..331	CDD:289560
		ANK	263..387	CDD:238125
		ANK repeat	267..298	CDD:293786
		ANK repeat	300..331	CDD:293786
		Ank_2	305..398	CDD:289560
		ANK	329..454	CDD:238125
		ANK repeat	367..398	CDD:293786
		ANK repeat	400..431	CDD:293786
		Ank_2	405..498	CDD:289560
		ANK	428..555	CDD:238125
		ANK repeat	433..463	CDD:293786
		ANK repeat	469..499	CDD:293786
		ANK	496..641	CDD:238125
		ANK repeat	501..532	CDD:293786
		Ank_2	507..616	CDD:289560
		ANK repeat	534..575	CDD:293786
		ANK repeat	577..616	CDD:293786
		Ank_2	625..722	CDD:289560
		ANK	654..780	CDD:238125
		ANK repeat	660..690	CDD:293786
		ANK repeat	692..723	CDD:293786
		Ank_2	697..790	CDD:289560
		ANK	720..847	CDD:238125
		ANK repeat	725..757	CDD:293786
		ANK repeat	759..790	CDD:293786
		Ank_5	779..834	CDD:290568
		ANK	787..915	CDD:238125
		ANK repeat	792..824	CDD:293786
		ANK repeat	861..893	CDD:293786
		Ank_4	865..915	CDD:290365
		Ank_4	929..995	CDD:290365
		ANK repeat	932..972	CDD:293786
		ANK	969..1096	CDD:238125	31/135 (23%)
		ANK repeat	974..1007	CDD:293786
		Ank_2	979..1074	CDD:289560	22/72 (31%)
		ANK repeat	1009..1041	CDD:293786	11/30 (37%)
		ANK	1039..1159	CDD:238125	31/176 (18%)
		ANK repeat	1043..1074	CDD:293786	9/39 (23%)
		Ank_2	1048..1135	CDD:289560	22/137 (16%)
		ANK repeat	1076..1101	CDD:293786	9/65 (14%)
		ANK repeat	1109..1134	CDD:293786	3/25 (12%)
		Ion_trans	<1393..1598	CDD:278921	50/223 (22%)
trpc2a	XP_017206723.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910