DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nompC and PIDD1

DIOPT Version :9

Sequence 1:	NP_523483.2	Gene:	nompC / 33768	FlyBaseID:	FBgn0016920	Length:	1761	Species:	Drosophila melanogaster
Sequence 2:	XP_005253062.1	Gene:	PIDD1 / 55367	HGNCID:	16491	Length:	934	Species:	Homo sapiens

Alignment Length:	283	Identity:	61/283 - (21%)
Similarity:	105/283 - (37%)	Gaps:	69/283 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   764 LHLAAASGQMEV-----CQLLLELGAN---IDATDDLGQKPIHVAAQNNYS----EVAKLFLQQH 816
            |..|||:|....     .:.|..||.|   :|......|:.:|:..|....    |..:|...:.
Human    10 LEAAAAAGDASEDSDAGSRALPFLGGNRLSLDLYPGGCQQLLHLCVQQPLQLLQVEFLRLSTHED 74

  Fly   817 PSLVNATSKDGNTCAHIAAMQGSVKVIEELM-----KFDRSGVISARNKLTDATPLQLA--AEGG 874
            |.|:.||         :|.:..|:..:..|:     :.|..|. ..|..||: .|..|:  |...
Human    75 PQLLEAT---------LAQLPQSLSCLRSLVLKGGQRRDTLGA-CLRGALTN-LPAGLSGLAHLA 128

  Fly   875 HADVVKALVRAGASCTEENKAGFTAVHLAAQNGHG------QVLDVLKSTNSLRINSKKLGLTP- 932
            |.|:....:....:|..:.: |..|:.|:    |.      :.|..|.:...|.:...:|...|
Human   129 HLDLSFNSLETLPACVLQMR-GLGALLLS----HNCLSELPEALGALPALTFLTVTHNRLQTLPP 188

  Fly   933 -LHVAAYYGQADTVRELLTSVPATVKSETPTGQSLFGDLGTESGMTPLHL---------AAFSGN 987
             |...:...:.|..:.||.::|..:           |.||:   :..|:|         |:.:|.
Human   189 ALGALSTLQRLDLSQNLLDTLPPEI-----------GGLGS---LLELNLASNRLQSLPASLAGL 239

  Fly   988 ENVVRLLLNS---AGVQVDAATI 1007
            .::..|:|:|   |.|..|.|.:
Human   240 RSLRLLVLHSNLLASVPADLARL 262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nompC	NP_523483.2	ANK repeat	129..157	CDD:293786
		Ank_2	131..228	CDD:289560
		ANK	155..319	CDD:238125
		ANK repeat	159..186	CDD:293786
		ANK repeat	232..265	CDD:293786
		Ank_2	237..331	CDD:289560
		ANK	263..387	CDD:238125
		ANK repeat	267..298	CDD:293786
		ANK repeat	300..331	CDD:293786
		Ank_2	305..398	CDD:289560
		ANK	329..454	CDD:238125
		ANK repeat	367..398	CDD:293786
		ANK repeat	400..431	CDD:293786
		Ank_2	405..498	CDD:289560
		ANK	428..555	CDD:238125
		ANK repeat	433..463	CDD:293786
		ANK repeat	469..499	CDD:293786
		ANK	496..641	CDD:238125
		ANK repeat	501..532	CDD:293786
		Ank_2	507..616	CDD:289560
		ANK repeat	534..575	CDD:293786
		ANK repeat	577..616	CDD:293786
		Ank_2	625..722	CDD:289560
		ANK	654..780	CDD:238125	5/20 (25%)
		ANK repeat	660..690	CDD:293786
		ANK repeat	692..723	CDD:293786
		Ank_2	697..790	CDD:289560	10/33 (30%)
		ANK	720..847	CDD:238125	21/94 (22%)
		ANK repeat	725..757	CDD:293786
		ANK repeat	759..790	CDD:293786	10/33 (30%)
		Ank_5	779..834	CDD:290568	14/61 (23%)
		ANK	787..915	CDD:238125	29/144 (20%)
		ANK repeat	792..824	CDD:293786	8/35 (23%)
		ANK repeat	861..893	CDD:293786	8/33 (24%)
		Ank_4	865..915	CDD:290365	11/57 (19%)
		Ank_4	929..995	CDD:290365	14/76 (18%)
		ANK repeat	932..972	CDD:293786	8/41 (20%)
		ANK	969..1096	CDD:238125	13/51 (25%)
		ANK repeat	974..1007	CDD:293786	11/44 (25%)
		Ank_2	979..1074	CDD:289560	11/41 (27%)
		ANK repeat	1009..1041	CDD:293786
		ANK	1039..1159	CDD:238125
		ANK repeat	1043..1074	CDD:293786
		Ank_2	1048..1135	CDD:289560
		ANK repeat	1076..1101	CDD:293786
		ANK repeat	1109..1134	CDD:293786
		Ion_trans	<1393..1598	CDD:278921
PIDD1	XP_005253062.1	leucine-rich repeat	39..63	CDD:275380	4/23 (17%)
		leucine-rich repeat	64..91	CDD:275380	8/35 (23%)
		LRR_RI	<117..>279	CDD:238064	34/165 (21%)
		LRR_8	126..183	CDD:290566	10/61 (16%)
		leucine-rich repeat	127..152	CDD:275380	4/25 (16%)
		leucine-rich repeat	153..172	CDD:275380	4/22 (18%)
		leucine-rich repeat	173..195	CDD:275380	4/21 (19%)
		LRR_8	194..252	CDD:290566	14/71 (20%)
		leucine-rich repeat	196..218	CDD:275380	6/32 (19%)
		leucine-rich repeat	219..241	CDD:275380	4/21 (19%)
		LRR_8	240..295	CDD:290566	7/23 (30%)
		leucine-rich repeat	242..264	CDD:275380	7/21 (33%)
		leucine-rich repeat	265..286	CDD:275380
		ZU5	325..398	CDD:295340
		Peptidase_S68	421..453	CDD:287439
		ZU5	465..537	CDD:295340
		Death_PIDD	812..897	CDD:260049
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900