DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nompC and tnks2

DIOPT Version :9

Sequence 1:	NP_523483.2	Gene:	nompC / 33768	FlyBaseID:	FBgn0016920	Length:	1761	Species:	Drosophila melanogaster
Sequence 2:	NP_001017008.2	Gene:	tnks2 / 549762	XenbaseID:	XB-GENE-968819	Length:	1167	Species:	Xenopus tropicalis

Alignment Length:	1103	Identity:	275/1103 - (24%)
Similarity:	410/1103 - (37%)	Gaps:	284/1103 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 LAAAGKDIRLKADGRGKIPLLLAVESGNQSMCRELLAAQTAEQLKATTANGDTALHLAARRRDVD 282
            :||||:..|         .|..|..:|:....|:|:.|..... :.|.....|.||.||.....|
Frog    19 MAAAGEPAR---------ELFEACRNGDVERVRKLVNADNVNS-RDTAGRKSTPLHFAAGFGRKD 73

  Fly   283 MVRILVDYGTNVDTQNGEGQTPLHIAAAEGDEALLKYFYGVRASASIADNQDRTPMHLAAENGHA 347
            :|..|:..|.||..::..|..|||.|.:.|...::.......|..:..||.:.||:|.||..|..
Frog    74 VVEHLLQSGANVHARDDGGLIPLHNACSFGHAEVVSLLLRHGADPNARDNWNYTPLHEAAIKGKI 138

  Fly   348 HVIEIL----ADKFKASIFERT------------------KDGSTLMHIASLNGHAECATMLFKK 390
            .|..:|    ||....:...||                  ||  .|:..|......:...:|...
Frog   139 DVCIVLLQHGADPTIRNTDSRTALDLSDPSAKAVLTGEYKKD--ELLESARSGNEEKMMALLTPL 201

  Fly   391 GVYLHMPNKDGARS--IHTAAAYGHTGIINTLLQKGEKVDVTTNDNYTALHIAVESAKPAVVETL 453
            .|..|.  .||.:|  :|.||.|....|:..|||.|..|......:...||.|.......|.|.|
Frog   202 NVNCHA--SDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELL 264

  Fly   454 LGFGADVHVRGGKLRETPLHIAARVKDGDRCALMLLKSGASPNLTTDDCLTPVHVAARHGNLATL 518
            :..||.|:.. ...:.||||.||.....:.|:| ||..||.|.:.  :|.....:     :||..
Frog   265 VKRGASVNAM-DLWQFTPLHEAASKNRVEVCSL-LLSYGADPTML--NCHNKSAI-----DLAPT 320

  Fly   519 MQLLEDEGDPLYKSNTGETPLHMACRACHPDIVRHL-IETVKEKHGPDKATTYINSVNEDGATAL 582
            .||.|    .|.....|.:.|..|..|....:.:|| :|.|..||            .:...|||
Frog   321 PQLKE----MLSYEFKGHSLLQAAREADLTRVKKHLSLEIVNFKH------------PQTHDTAL 369

  Fly   583 HYTCQITKEEVKIPESDKQIVRMLLENGADVTLQTKTALETAFHYCAVAGNNDVLMEMISHMNPT 647
            |  |..:....|    .||:..:|...||:|:.:||..|
Frog   370 H--CAASSPYPK----RKQVCELLFRKGANVSEKTKDFL-------------------------- 402

  Fly   648 DIQKAMNRQSSVGWTPLLIACHRGHMELVNNLLANHARVDVFDTEGRSALHLAAERGYLHVCDAL 712
                          |||.:|..:.|.::|..|:.:.|:|:..|..|:::||.||..|:|..|..|
Frog   403 --------------TPLHVASDKAHNDIVEVLIKHEAKVNALDNLGQTSLHRAAHCGHLQTCRLL 453

  Fly   713 LTNKAFINSKSRVGRTALHL--------------------------AAMNGFTHLVKFLIKDHNA 751
            |.:....:..|..|.|||.:                          ||..|....||.|....:.
Frog   454 LNSGCDPSIVSLQGFTALQMGNESVQQILQEGLPFSNTDADRQLLEAAKAGDVETVKKLCTSQSV 518

  Fly   752 VIDILTLRKQTPLHLAAASGQMEVCQLLLELGANIDATDDLGQKPIHVAAQNNYSEVAKLFLQQH 816
            ....:..|:.||||.||...::.|.:.||:.||::.|.|..|..|:|.|....:.||.:| |.:|
Frog   519 NCRDIEGRQSTPLHFAAGYNRVAVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVTEL-LVKH 582

  Fly   817 PSLVNATSKDGNTCAHIAAMQGSVKVIEELMKFDRSGVISARNKLTDATPLQLAAEGGHADVVKA 881
            .:::|                     :.:|.||               |||..||..|..::.|.
Frog   583 GAVIN---------------------VADLWKF---------------TPLHEAAAKGKYEICKL 611

  Fly   882 LVRAGASCTEENKAGFTAVHLAAQNGHGQVLDVLKSTNSLRINSKKLGLTPLHVAAYYGQADTVR 946
            |::.||..|::|:.|.|.:.| .::|...:.|:|:...:|...:||            |....|:
Frog   612 LLQHGADSTKKNRDGNTPLDL-VKDGDTDIQDLLRGDAALLDAAKK------------GCVSRVK 663

  Fly   947 ELLTSVPATVKSETPTGQSLFGDLGTESGMTPLHLAAFSGNENVVRLLLNSAGVQVDAATIENGY 1011
            :|.|  |..|......|:.          .|||||||                          ||
Frog   664 KLCT--PENVNCRDTQGRH----------STPLHLAA--------------------------GY 690

  Fly  1012 NPLHLACFGGHMSVVGLLLSRSAELLQSQDRNGRTGLHIAAMHGHIQMVEILLGQGAEINATDRN 1076
            |.|.:|.:         ||...|: :.:||:.|...||.||.:||:.:..:|:...|.:||||:.
Frog   691 NNLEVAEY---------LLQNGAD-VNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKW 745

  Fly  1077 GWTPLHCAAKAGHLEVVKLLCEAGASPKSETNYGCAAIWFAASEGHNEVLRYLMNKEHDTYGLME 1141
            .:||||.||:.|..::..||...||.|..:...|.|.:....::....:|...|..
Frog   746 AFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQAPLDLVTADDVRALLTAAMPP--------- 801

  Fly  1142 DKRFVYNLMVVSKNHNNKPIQEFVLVSPAPVDTAAKLSNIYIVLSTKEKERAKDLVAAGKQCEAM 1206
                      .:.:...||  :.:.||.......|.||::.....|.....:.|.:|:|.. ||.
Frog   802 ----------AALSTFYKP--QLINVSQPSATAVATLSSVPSSSPTLSAASSLDNLASGFS-EAT 853

  Fly  1207 ATELLALAAGSDSAGKILQATDKRNVEF------------------------LDVLIENEQKE 1245
            :..    :.|::.|..:.:..:...||.                        ||||||...||
Frog   854 SVS----SGGAEGASGLDKKEEVPGVELSINQFLRNLGLEHLIDIFEREQITLDVLIEMGHKE 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nompC	NP_523483.2	ANK repeat	129..157	CDD:293786
		Ank_2	131..228	CDD:289560	5/9 (56%)
		ANK	155..319	CDD:238125	29/100 (29%)
		ANK repeat	159..186	CDD:293786
		ANK repeat	232..265	CDD:293786	6/32 (19%)
		Ank_2	237..331	CDD:289560	25/93 (27%)
		ANK	263..387	CDD:238125	37/145 (26%)
		ANK repeat	267..298	CDD:293786	11/30 (37%)
		ANK repeat	300..331	CDD:293786	7/30 (23%)
		Ank_2	305..398	CDD:289560	26/114 (23%)
		ANK	329..454	CDD:238125	39/148 (26%)
		ANK repeat	367..398	CDD:293786	6/30 (20%)
		ANK repeat	400..431	CDD:293786	13/32 (41%)
		Ank_2	405..498	CDD:289560	32/92 (35%)
		ANK	428..555	CDD:238125	35/127 (28%)
		ANK repeat	433..463	CDD:293786	9/29 (31%)
		ANK repeat	469..499	CDD:293786	13/29 (45%)
		ANK	496..641	CDD:238125	32/145 (22%)
		ANK repeat	501..532	CDD:293786	7/30 (23%)
		Ank_2	507..616	CDD:289560	28/109 (26%)
		ANK repeat	534..575	CDD:293786	10/41 (24%)
		ANK repeat	577..616	CDD:293786	12/38 (32%)
		Ank_2	625..722	CDD:289560	20/96 (21%)
		ANK	654..780	CDD:238125	39/151 (26%)
		ANK repeat	660..690	CDD:293786	9/29 (31%)
		ANK repeat	692..723	CDD:293786	10/30 (33%)
		Ank_2	697..790	CDD:289560	33/118 (28%)
		ANK	720..847	CDD:238125	35/152 (23%)
		ANK repeat	725..757	CDD:293786	10/57 (18%)
		ANK repeat	759..790	CDD:293786	13/30 (43%)
		Ank_5	779..834	CDD:290568	16/54 (30%)
		ANK	787..915	CDD:238125	32/127 (25%)
		ANK repeat	792..824	CDD:293786	10/31 (32%)
		ANK repeat	861..893	CDD:293786	11/31 (35%)
		Ank_4	865..915	CDD:290365	17/49 (35%)
		Ank_4	929..995	CDD:290365	14/65 (22%)
		ANK repeat	932..972	CDD:293786	7/39 (18%)
		ANK	969..1096	CDD:238125	37/126 (29%)
		ANK repeat	974..1007	CDD:293786	7/32 (22%)
		Ank_2	979..1074	CDD:289560	26/94 (28%)
		ANK repeat	1009..1041	CDD:293786	8/31 (26%)
		ANK	1039..1159	CDD:238125	31/119 (26%)
		ANK repeat	1043..1074	CDD:293786	11/30 (37%)
		Ank_2	1048..1135	CDD:289560	28/86 (33%)
		ANK repeat	1076..1101	CDD:293786	9/24 (38%)
		ANK repeat	1109..1134	CDD:293786	4/24 (17%)
		Ion_trans	<1393..1598	CDD:278921
tnks2	NP_001017008.2	PTZ00322	28..>114	CDD:140343	24/86 (28%)
		ANK repeat	61..89	CDD:293786	11/27 (41%)
		PHA02876	<74..>438	CDD:165207	111/438 (25%)
		ANK repeat	91..122	CDD:293786	7/30 (23%)
		ANK repeat	124..155	CDD:293786	10/30 (33%)
		ANK repeat	214..242	CDD:293786	10/27 (37%)
		ANK repeat	244..275	CDD:293786	9/31 (29%)
		ANK repeat	277..308	CDD:293786	13/33 (39%)
		ANKYR	310..>472	CDD:223738	55/228 (24%)
		ANK repeat	366..398	CDD:293786	12/37 (32%)
		ANK repeat	400..431	CDD:293786	10/70 (14%)
		ANK repeat	434..522	CDD:293786	21/87 (24%)
		PHA03095	495..>804	CDD:222980	107/425 (25%)
		ANK repeat	529..557	CDD:293786	12/27 (44%)
		ANK repeat	559..590	CDD:293786	10/52 (19%)
		ANK repeat	592..623	CDD:293786	13/45 (29%)
		ANK repeat	645..675	CDD:293786	9/43 (21%)
		ANK repeat	682..710	CDD:293786	15/63 (24%)
		ANK repeat	712..743	CDD:293786	11/30 (37%)
		ANK repeat	745..776	CDD:293786	12/30 (40%)
		SAM_tankyrase1,2	872..937	CDD:188923	10/41 (24%)
		tankyrase_like	940..1161	CDD:238718
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1759
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940