DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nompC and CG10011

DIOPT Version :9

Sequence 1:	NP_523483.2	Gene:	nompC / 33768	FlyBaseID:	FBgn0016920	Length:	1761	Species:	Drosophila melanogaster
Sequence 2:	NP_651624.2	Gene:	CG10011 / 43387	FlyBaseID:	FBgn0039590	Length:	2119	Species:	Drosophila melanogaster

Alignment Length:	1103	Identity:	248/1103 - (22%)
Similarity:	408/1103 - (36%)	Gaps:	317/1103 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 RMIELGADVGARNNDNYNVLHIAAMYSRE----------DVVKLLLT--KRGVDPFSTGGSRSQT 197
            :|::|..:.|..|.::.|... :::.|.|          ::..|||:  |..:......||.|:.
  Fly  1142 KMLKLLIETGINNAESQNSCE-SSLMSPELSEKSQNIDFELADLLLSSEKSCLMETQRAGSPSEH 1205

  Fly   198 AVHLVSSRQTGTATNILRALLAAAGKDIRLKADGRGKIPL-LLAVESGNQSMCRELLAAQTAEQL 261
            :.....| |...|::.|..|  :....|.|.   :||..: :||.:..:|.:.|.|.|.::...|
  Fly  1206 SEPPAES-QDENASSTLHQL--SDSHHIELH---KGKALIHILANDGNHQLLERALNACKSPIDL 1264

  Fly   262 KATTANGDTALHLAARRRDVDMVRILVDYGTNVDTQNGEGQTPLHIAAAEGDEALLKYFYGVRAS 326
            :....||.|||::|||...:::|::|:.:  :....:|.|:..                   |..
  Fly  1265 EIEDYNGQTALNIAARNGHLEVVKLLLSF--SQPCNDGTGRMK-------------------RVD 1308

  Fly   327 ASIADNQDRTPMHLAAENGHAHVIEILADKFKASIFERTKDGSTLMHIASLNGHAECATMLFKKG 391
            .:.||....||:..|:..||:.|:.:|..:....|....|:|.|.:..|:.:||.:...:|.:.|
  Fly  1309 VNHADRDGWTPLRSASWGGHSEVVRLLIAQPACKIDLADKEGRTALRAAAWSGHEDILKLLIESG 1373

  Fly   392 VYLHMPNKDGARSIHTAAAYGHTGIINTLLQKGEKVDVTTNDNYTALHIAV---ESAKPAVVETL 453
            ..::..::.|..|:..|:..||..|:..||:.|..|:....|..:||.:|.   .|....|:.||
  Fly  1374 ADVNSVDRQGRTSLIAASYMGHYDIVEILLENGANVNHLDLDGRSALCVAALCGSSGYSKVISTL 1438

  Fly   454 LGFGADVHVRGGKLRETPLHIAARVKDGDRCALMLLKSGASPNLTTDDCLTPVHVAARHGNLATL 518
            |..||:.                                   :...:|.::|:.|::..||....
  Fly  1439 LDHGANT-----------------------------------DQLDNDGMSPLLVSSFEGNAEVC 1468

  Fly   519 MQLLEDEGDPLYKSNTGETPLHMACRACHPDIVRHLIETVKEKHGPDKATTY----INSVNEDGA 579
            ..|||:..||......|.|||..||.|.|..:|:.|:              :    |:.::.:|.
  Fly  1469 ELLLENAADPDLADFMGRTPLWAACTAGHATVVKLLL--------------FWGCGIDCMDSEGR 1519

  Fly   580 TALHYTCQITKEEVKIPESDKQIVRMLLENGADVTLQTKTALETAFHYCAVAGNNDVLMEMISHM 644
            |.|         .:...:.:.:.||.||:.|.|.|
  Fly  1520 TVL---------SIGAAQGNVETVRQLLDRGLDET------------------------------ 1545

  Fly   645 NPTDIQKAMNRQSSVGWTPLLIACHRGHMELVNNLLANHARVDVFDTEGRSALHLAAERGYLHVC 709
                      .:.:.|||||..|...|..|:...||.:.|::|..|.||::||||||:.|.||..
  Fly  1546 ----------HRDNAGWTPLHYAAFEGFHEVCLQLLESGAKIDECDNEGKTALHLAAQEGRLHCV 1600

  Fly   710 DALL-TNKAFINSKSRVGRTALHLAAMNGFTHLVKFLIK---DHNAVIDILTLRKQTPLHLAAAS 770
            .||| .:.:|::.|:..|:||..||.:.|....|:||:|   |.|:    .....:|.|::.|..
  Fly  1601 QALLDIHSSFVDQKAHDGKTAFRLACLEGHMDTVEFLLKFCCDVNS----KDADSRTTLYILALE 1661

  Fly   771 GQMEVCQLLLELGANIDATDDLGQKPIHVAAQNNYSEVAKLFLQQHPSLVNATSKDGNTCAHIAA 835
            .::|:.:.||:: .|:|                                ||....:|.|..|:||
  Fly  1662 NKLEIVKYLLDM-TNVD--------------------------------VNIPDSEGRTALHVAA 1693

  Fly   836 MQGSVKVIEELMKFDRSGVISARNKLTDATPLQLAAEGGHADVVKALVRAGASCTEENKAGFTAV 900
            .|                                    ||||:||.|:.|||.....:....|.:
  Fly  1694 WQ------------------------------------GHADMVKTLIEAGADVNSMDLEARTPL 1722

  Fly   901 HLAAQNGHGQVLDVLKSTNSLRINSKKLGLTPLHVAAYYGQADTVRELLTSVPATVKSETPTGQS 965
            |..|..|:..|:::|....:|..::.|.|.|.|.::|..|....|..||.......||:
  Fly  1723 HSCAWQGNHDVMNILLYYGALADHACKQGATALGISAQEGHEKCVIALLQFGANPYKSD------ 1781

  Fly   966 LFGDLGTESGMTPLHLAAFSGNENVVRLLLNSAGVQVDAATIENGYNPLHLACFGGHMSVVGLLL 1030
                   ..|.||:.|||.|...:::::.        ::.|.....|| :...|..|
  Fly  1782 -------HCGRTPIKLAAKSSRTSILKIF--------ESYTKNEASNP-NEPKFHAH-------- 1822

  Fly  1031 SRSAELLQSQDRNGRTGLH--IAAMHGHIQMVEILLGQGAEINATDRNGWTPLHCAAKAGHLEVV 1093
               |.:|:|.|:.....||  :|....|.....:.   .|...||..||          .||.|:
  Fly  1823 ---ASMLRSPDQPPALPLHQNLAPYPAHASASSVC---SAATTATVHNG----------SHLHVL 1871

  Fly  1094 KLLCEAGASPKSETNYGCAAIWFAASEGHNEVLRYLMNKEHDTYGLMEDKRFVYNLMVVSKNHNN 1158
                .|.:|..|..|:                  |....:.||..|.:.|      .|:|.....
  Fly  1872 ----NASSSTHSSNNF------------------YQNTMQSDTSSLHKRK------SVISSQSTG 1908

  Fly  1159 KPIQEFVLVSPAPVDTAAKLSNIYIVLSTKEKERAKDLVAAGKQCEAMATELLALAAGSDSAG 1221
            ....:..|.....:...:|||:            ..:|:...|...:..      |||..|:|
  Fly  1909 SSNDQAPLTFTQQLQRQSKLSS------------RNNLMVNSKHASSSG------AAGHKSSG 1953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nompC	NP_523483.2	ANK repeat	129..157	CDD:293786	3/11 (27%)
		Ank_2	131..228	CDD:289560	20/94 (21%)
		ANK	155..319	CDD:238125	39/176 (22%)
		ANK repeat	159..186	CDD:293786	7/38 (18%)
		ANK repeat	232..265	CDD:293786	9/33 (27%)
		Ank_2	237..331	CDD:289560	20/94 (21%)
		ANK	263..387	CDD:238125	29/123 (24%)
		ANK repeat	267..298	CDD:293786	10/30 (33%)
		ANK repeat	300..331	CDD:293786	2/30 (7%)
		Ank_2	305..398	CDD:289560	19/92 (21%)
		ANK	329..454	CDD:238125	35/127 (28%)
		ANK repeat	367..398	CDD:293786	7/30 (23%)
		ANK repeat	400..431	CDD:293786	10/30 (33%)
		Ank_2	405..498	CDD:289560	19/95 (20%)
		ANK	428..555	CDD:238125	30/129 (23%)
		ANK repeat	433..463	CDD:293786	11/32 (34%)
		ANK repeat	469..499	CDD:293786	0/29 (0%)
		ANK	496..641	CDD:238125	31/148 (21%)
		ANK repeat	501..532	CDD:293786	10/30 (33%)
		Ank_2	507..616	CDD:289560	29/112 (26%)
		ANK repeat	534..575	CDD:293786	11/44 (25%)
		ANK repeat	577..616	CDD:293786	10/38 (26%)
		Ank_2	625..722	CDD:289560	28/97 (29%)
		ANK	654..780	CDD:238125	45/129 (35%)
		ANK repeat	660..690	CDD:293786	12/29 (41%)
		ANK repeat	692..723	CDD:293786	15/31 (48%)
		Ank_2	697..790	CDD:289560	33/96 (34%)
		ANK	720..847	CDD:238125	29/129 (22%)
		ANK repeat	725..757	CDD:293786	12/34 (35%)
		ANK repeat	759..790	CDD:293786	8/30 (27%)
		Ank_5	779..834	CDD:290568	9/54 (17%)
		ANK	787..915	CDD:238125	24/127 (19%)
		ANK repeat	792..824	CDD:293786	2/31 (6%)
		ANK repeat	861..893	CDD:293786	10/31 (32%)
		Ank_4	865..915	CDD:290365	15/49 (31%)
		Ank_4	929..995	CDD:290365	17/65 (26%)
		ANK repeat	932..972	CDD:293786	8/39 (21%)
		ANK	969..1096	CDD:238125	28/128 (22%)
		ANK repeat	974..1007	CDD:293786	7/32 (22%)
		Ank_2	979..1074	CDD:289560	19/96 (20%)
		ANK repeat	1009..1041	CDD:293786	7/31 (23%)
		ANK	1039..1159	CDD:238125	25/121 (21%)
		ANK repeat	1043..1074	CDD:293786	6/32 (19%)
		Ank_2	1048..1135	CDD:289560	17/88 (19%)
		ANK repeat	1076..1101	CDD:293786	6/24 (25%)
		ANK repeat	1109..1134	CDD:293786	1/24 (4%)
		Ion_trans	<1393..1598	CDD:278921
CG10011	NP_651624.2	AAA	344..457	CDD:214640
		Methylase_S	<772..885	CDD:279728
		Ank_4	1237..1291	CDD:290365	16/53 (30%)
		ANK	1266..1403	CDD:238125	37/157 (24%)
		ANK repeat	1270..1313	CDD:293786	13/63 (21%)
		Ank_2	1275..1380	CDD:289560	27/125 (22%)
		ANK repeat	1315..1347	CDD:293786	8/31 (26%)
		ANK repeat	1349..1380	CDD:293786	7/30 (23%)
		Ank_2	1354..1449	CDD:289560	26/129 (20%)
		ANK repeat	1382..1413	CDD:293786	10/30 (33%)
		ANK	1410..1538	CDD:238125	37/185 (20%)
		ANK repeat	1415..1446	CDD:293786	11/65 (17%)
		Ank_5	1438..1489	CDD:290568	16/85 (19%)
		ANK	1479..1604	CDD:238125	46/187 (25%)
		ANK repeat	1484..1515	CDD:293786	11/44 (25%)
		Ank_2	1489..1581	CDD:289560	30/154 (19%)
		ANK repeat	1517..1548	CDD:293786	10/79 (13%)
		ANK repeat	1550..1581	CDD:293786	12/30 (40%)
		Ank_2	1555..1648	CDD:289560	37/96 (39%)
		ANK	1578..1705	CDD:238125	52/199 (26%)
		ANK repeat	1617..1648	CDD:293786	12/34 (35%)
		Ank_2	1624..1715	CDD:289560	35/163 (21%)
		ANK	1645..1771	CDD:238125	41/198 (21%)
		ANK repeat	1650..1682	CDD:293786	10/64 (16%)
		ANK repeat	1684..1715	CDD:293786	16/66 (24%)
		Ank_2	1689..1781	CDD:289560	31/127 (24%)
		ANK repeat	1717..1742	CDD:293786	6/24 (25%)
		ANK repeat	1750..1775	CDD:293786	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3248
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.920