DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nompC and Ank2

DIOPT Version :9

Sequence 1:	NP_523483.2	Gene:	nompC / 33768	FlyBaseID:	FBgn0016920	Length:	1761	Species:	Drosophila melanogaster
Sequence 2:	XP_038959927.1	Gene:	Ank2 / 362036	RGDID:	620156	Length:	4173	Species:	Rattus norvegicus

Alignment Length:	1193	Identity:	303/1193 - (25%)
Similarity:	474/1193 - (39%)	Gaps:	342/1193 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 EAELKKLEKYVANVGEDGNHIPLAGVHDMNTGMTPLMYATKDNKTAIMDRMIELGADVGARNNDN 160
            ||||.:.||.:....:....||                         .|||     :...:::.|
  Rat    13 EAELDEKEKNLERERKKQRKIP-------------------------RDRM-----ERKRKSDSN 47

  Fly   161 YNVLHIAAMYSREDVVKLLLTKRGVDPFSTGGSRSQTAVHLVSSRQTGTATNILRALLAAAGKDI 225
            .:.|..|...:.:.||:.|  |.|:| .:|.......|:|
  Rat    48 ASFLRAARAGNLDKVVEYL--KGGID-INTCNQNGLNALH------------------------- 84

  Fly   226 RLKADGRGKIPLLLAVESGNQSMCRELLAAQTAEQLKATTANGDTALHLAARRRDVDMVRILVDY 290
                         ||.:.|:..:.:|||.  ....:.:.|..|:||||:|:.....::|::||..
  Rat    85 -------------LAAKEGHVGLVQELLG--RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKE 134

  Fly   291 GTNVDTQNGEGQTPLHIAAAEGDEALLKYFYGVRASASIADNQDRTPMHLAAENGHAHVIEILAD 355
            |.|::.|:..|.|||::||.|....::||.....|:.|.|.....||:.:|.:.||...:.||.:
  Rat   135 GANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE 199

  Fly   356 ------------------------------------KFKASIFERTKDGSTLMHIASLNGHAECA 384
                                                :.|..:...|:.|.|.:|||:..|:...|
  Rat   200 NDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA 264

  Fly   385 TMLFKKGVYLHMPNKDGARSIHTAAAYGHTGIINTLLQKGEKVDVTTNDNYTALHIAVESAKPAV 449
            |:|..:|..:....::|...:|.|:..|:|.::..||.:|.::|..|.|..|.||.|..|....|
  Rat   265 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQV 329

  Fly   450 VETLLGFGADVHVRGGKLRETPLHIAARVKDGD--RCALMLLKSGASPNLTTDDCLTPVHVAARH 512
            ||.||..||.:..| .|...:|||:||:   ||  .|...||:..|..:..|.|.||.:||||..
  Rat   330 VELLLERGAPLLAR-TKNGLSPLHMAAQ---GDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHC 390

  Fly   513 GNLATLMQLLEDEGDPLYKSNTGETPLHMACRACHPDIVRHLIETVKEKHGPDKATTYINSVNED 577
            |:......||:...:|..::..|.||||:||:
  Rat   391 GHYRVTKLLLDKRANPNARALNGFTPLHIACK--------------------------------- 422

  Fly   578 GATALHYTCQITKEEVKIPESDKQIVRMLLENGADVTLQTKTALETAFHYCAVAGNNDVLMEMIS 642
                        |..:|:.|       :|::.||.:...|::
  Rat   423 ------------KNRIKVME-------LLVKYGASIQAITES----------------------- 445

  Fly   643 HMNPTDIQKAMNRQSSVGWTPLLIACHRGHMELVNNLLANHARVDVFDTEGRSALHLAAERGYLH 707
                             |.||:.:|...||:.:|..||.|.|..||.:..|.:|||:||..|.:.
  Rat   446 -----------------GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVE 493

  Fly   708 VCDALLTNKAFINSKSRVGRTALHLAAMNGFTHLVKFLIKDHNAVIDILTLRKQTPLHLAAASGQ 772
            |...||.|.|.:::::|..:|.||:|:..|.|.:|:.|:: |.|..|..|....||||::|..||
  Rat   494 VVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ-HMAHPDAATTNGYTPLHISAREGQ 557

  Fly   773 MEVCQLLLELGANIDATDDLGQKPIHVAAQNNYSEVAKLFLQQHPSLVNATSKDGNTCAHIAAMQ 837
            ::|..:|||.||........|..|:||||:....:||||.||:. :..::..|:|.|..|:||..
  Rat   558 VDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRR-AAADSAGKNGLTPLHVAAHY 621

  Fly   838 GSVKVIEELMKFDRSGVISARNKLTDATPLQLAAEGGHADVVKALVRAGASCTEENKAGFTAVHL 902
            .:.||...|::...|...:|:|   ..|||.:||:.....:...|:..||......|.|.|.:||
  Rat   622 DNQKVALLLLEKGASPHATAKN---GYTPLHIAAKKNQMQIASTLLNYGAETNTVTKQGVTPLHL 683

  Fly   903 AAQNGHGQVLDVL--KSTNSLRINSKKLGLTPLHVAAYYGQADTVRELLTSVPATVKSETPTGQS 965
            |:|.||..::.:|  |..|             :|
  Rat   684 ASQEGHTDMVTLLLEKGAN-------------IH------------------------------- 704

  Fly   966 LFGDLGTESGMTPLHLAAFSGNENVVRLLLNSAGVQVDAATIENGYNPLHLACFGGHMSVVGLLL 1030
                :.|:||:|.|||||.....||.. :|...|...||.| :.||.||.:||.
  Rat   705 ----MSTKSGLTSLHLAAQEDKVNVAD-ILTKHGADQDAYT-KLGYTPLIVACH----------- 752

  Fly  1031 SRSAELLQSQDRNGRTGLHIAAMHGHIQMVEILLGQGAEINATDRNGWTPLHCAAKAGHLEVVKL 1095
                                   :|:::||..||.|||.:||..:||:||||.||:.||..::.:
  Rat   753 -----------------------YGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINV 794

  Fly  1096 LCEAGASPKSETNYGCAAIWFAASEGHNEVLRYLMNKEHDTYGLMEDKRFVYNLMVVSKNHNNKP 1160
            |.:.||.|.:.|..|..|:..|...|:..|:        ||..::.::.......:..|:..|.|
  Rat   795 LLQHGAKPNATTANGNTALAIAKRLGYISVV--------DTLKVVTEEVTTTTTTITEKHKLNVP 851

  Fly  1161 IQEFVLVSPAPVDTAAKLSNIYIVLSTKEKERAKDLVAAGKQCEAMATELLALAAGSDS----AG 1221
                        :|..:      ||...::|..|.........||::.      :|.|:    .|
  Rat   852 ------------ETMTE------VLDVSDEEALKQFGDHFIDGEALSD------SGDDTVTGDGG 892

  Fly  1222 KILQATDKRNV--------EFLD 1236
            :.|:..|.:.:        :|||
  Rat   893 EYLRPEDLKELGDDSLPSSQFLD 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nompC	NP_523483.2	ANK repeat	129..157	CDD:293786	3/27 (11%)
		Ank_2	131..228	CDD:289560	15/96 (16%)
		ANK	155..319	CDD:238125	38/163 (23%)
		ANK repeat	159..186	CDD:293786	8/26 (31%)
		ANK repeat	232..265	CDD:293786	6/32 (19%)
		Ank_2	237..331	CDD:289560	30/93 (32%)
		ANK	263..387	CDD:238125	42/159 (26%)
		ANK repeat	267..298	CDD:293786	11/30 (37%)
		ANK repeat	300..331	CDD:293786	11/30 (37%)
		Ank_2	305..398	CDD:289560	28/128 (22%)
		ANK	329..454	CDD:238125	39/160 (24%)
		ANK repeat	367..398	CDD:293786	10/30 (33%)
		ANK repeat	400..431	CDD:293786	9/30 (30%)
		Ank_2	405..498	CDD:289560	35/94 (37%)
		ANK	428..555	CDD:238125	47/128 (37%)
		ANK repeat	433..463	CDD:293786	13/29 (45%)
		ANK repeat	469..499	CDD:293786	11/31 (35%)
		ANK	496..641	CDD:238125	26/144 (18%)
		ANK repeat	501..532	CDD:293786	11/30 (37%)
		Ank_2	507..616	CDD:289560	21/108 (19%)
		ANK repeat	534..575	CDD:293786	7/40 (18%)
		ANK repeat	577..616	CDD:293786	6/38 (16%)
		Ank_2	625..722	CDD:289560	25/96 (26%)
		ANK	654..780	CDD:238125	46/125 (37%)
		ANK repeat	660..690	CDD:293786	13/29 (45%)
		ANK repeat	692..723	CDD:293786	12/30 (40%)
		Ank_2	697..790	CDD:289560	36/92 (39%)
		ANK	720..847	CDD:238125	46/126 (37%)
		ANK repeat	725..757	CDD:293786	11/31 (35%)
		ANK repeat	759..790	CDD:293786	13/30 (43%)
		Ank_5	779..834	CDD:290568	21/54 (39%)
		ANK	787..915	CDD:238125	41/127 (32%)
		ANK repeat	792..824	CDD:293786	12/31 (39%)
		ANK repeat	861..893	CDD:293786	8/31 (26%)
		Ank_4	865..915	CDD:290365	17/49 (35%)
		Ank_4	929..995	CDD:290365	12/65 (18%)
		ANK repeat	932..972	CDD:293786	1/39 (3%)
		ANK	969..1096	CDD:238125	42/126 (33%)
		ANK repeat	974..1007	CDD:293786	14/32 (44%)
		Ank_2	979..1074	CDD:289560	28/94 (30%)
		ANK repeat	1009..1041	CDD:293786	6/31 (19%)
		ANK	1039..1159	CDD:238125	33/119 (28%)
		ANK repeat	1043..1074	CDD:293786	10/30 (33%)
		Ank_2	1048..1135	CDD:289560	30/86 (35%)
		ANK repeat	1076..1101	CDD:293786	11/24 (46%)
		ANK repeat	1109..1134	CDD:293786	5/24 (21%)
		Ion_trans	<1393..1598	CDD:278921
Ank2	XP_038959927.1	Ank_2	52..>309	CDD:423045	68/299 (23%)
		ANK repeat	78..109	CDD:293786	8/70 (11%)
		ANK repeat	111..142	CDD:293786	11/30 (37%)
		ANK repeat	144..169	CDD:293786	9/24 (38%)
		Ank_2	200..>442	CDD:423045	73/297 (25%)
		ANK repeat	210..245	CDD:293786	1/34 (3%)
		ANK repeat	247..278	CDD:293786	10/30 (33%)
		ANK repeat	280..311	CDD:293786	9/30 (30%)
		ANK repeat	313..343	CDD:293786	13/29 (45%)
		ANK repeat	346..377	CDD:293786	11/33 (33%)
		ANK repeat	379..409	CDD:293786	11/29 (38%)
		ANK repeat	412..443	CDD:293786	13/82 (16%)
		PHA03095	419..>704	CDD:222980	104/394 (26%)
		ANK repeat	445..476	CDD:293786	13/70 (19%)
		ANK repeat	478..509	CDD:293786	12/30 (40%)
		ANK repeat	511..540	CDD:293786	10/29 (34%)
		ANK repeat	544..569	CDD:293786	11/24 (46%)
		Ank_2	576..>800	CDD:423045	88/311 (28%)
		ANK repeat	577..602	CDD:293786	12/25 (48%)
		ANK repeat	610..641	CDD:293786	9/30 (30%)
		ANK repeat	643..674	CDD:293786	9/33 (27%)
		ANK repeat	676..705	CDD:293786	12/76 (16%)
		ANK repeat	709..740	CDD:293786	14/31 (45%)
		ANK repeat	742..773	CDD:293786	16/64 (25%)
		ANK repeat	775..804	CDD:293786	14/28 (50%)
		Ank_4	776..828	CDD:372654	20/59 (34%)
		ZU5	1023..1160	CDD:128514
		UPA_2	1381..1510	CDD:375346
		PTZ00121	<1611..2375	CDD:173412
		PHA03307	1760..>2041	CDD:223039
		PHA03307	3231..>3468	CDD:223039
		Death_ank2	3616..3699	CDD:260066
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910