DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nompC and Hace1

DIOPT Version :9

Sequence 1:	NP_523483.2	Gene:	nompC / 33768	FlyBaseID:	FBgn0016920	Length:	1761	Species:	Drosophila melanogaster
Sequence 2:	XP_006256657.1	Gene:	Hace1 / 361866	RGDID:	1306114	Length:	916	Species:	Rattus norvegicus

Alignment Length:	560	Identity:	120/560 - (21%)
Similarity:	215/560 - (38%)	Gaps:	131/560 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   738 FTHLVKFLIKDHNAVIDILTLR-----------KQTPLHLAAASGQMEVCQLLLELGANIDATDD 791
            :|.:...:...|.:|.::|:..           |::.||:||..|.:|...|||:.|||.:..|.
  Rat    32 YTLMPMVMADQHRSVSELLSNSKFDVNYAFGRVKRSLLHIAANCGSVECLVLLLKKGANPNYQDI 96

  Fly   792 LGQKPIHVAAQNNYSE-VAKLFLQQHPSLVNATSKDGNTCAHIAAMQGSVKVIEELMKFDRSGVI 855
            .|..|:|:||:|...: ::||.  ::.:.||..:.:|.|..|..|:.|..:::.:|::
  Rat    97 SGCTPLHLAARNGQKKCMSKLL--EYSADVNICNNEGLTAIHWLAVNGRTELLHDLVQ------- 152

  Fly   856 SARNKLTDA--------TPLQLAAEGGHADVVKALVRAGASCTEENKAGFTAVHLAAQNGHGQVL 912
                .:||.        |.|.:|.:.||...|:.|:.:||.....|.||.|.::.|..:|.....
  Rat   153 ----HVTDVDVEDAMGQTALHVACQNGHKTTVQCLLDSGADINRPNVAGATPLYFACSHGQRDTA 213

  Fly   913 DVLKSTNSLRINSKKLGLTPLHVAAYYGQADTVRELLTSVPATVKSETPTGQSLFGDLGTESGMT 977
            .:|....:..:..|. |:|||.:....|...|...|:...|...::.....|:  .||
  Rat   214 QILLLRGAKYLPDKN-GVTPLDLCVQGGYGQTCEVLIQYHPRLFQTIVQMTQN--EDL------- 268

  Fly   978 PLHLAAFSGNENVVRLLLNSAGVQVDAATIENGYNPLHLACFGGH--MSVVGLLLSRSAELLQSQ 1040
                     .||::|.:|.....|.::..::.......:|...||  :||..|:.|.|:    |.
  Rat   269 ---------RENMLRQVLQHLSQQSESQYLKILTGLAEVATTNGHKLLSVFRLVSSLSS----SY 320

  Fly  1041 DRNGRTGLHIAAMHGHIQMVEILLGQGAEINATDR--NGWTPLHCAAKAGHLEVVKLLCEAGASP 1103
            :...::.|.|..:..|:    ..:|..:..|..|.  ||                      ..:|
  Rat   321 EAQMKSLLRIVRIFCHV----FRIGPSSPSNGMDMGYNG----------------------NKTP 359

  Fly  1104 KSETNYGCAAIWFAASEGHNEVLRYLMNKEHDTYGLMEDKRFVYNLMVVSKNHNNKPIQEFVLVS 1168
            :|:.......:|.:..|....:...||..:       ||...:.::::..|..:    ||...:|
  Rat   360 RSQVFKPLELLWHSLDEWLVLIATELMKNK-------EDSADITSILLKQKGQD----QEASCIS 413

  Fly  1169 ----PAPVDTAAKLSNIYIVLSTKEKERAKDLVAAGKQCEAMATELLALAAGSDSAGKILQA--- 1226
                |.|        ..|..|||...|...|::|..::..|...:::::.|...||  ::||
  Rat   414 AFEPPGP--------GSYERLSTGPGESKPDVLAGKQEASADCQDVISVTANRLSA--VIQAFYM 468

  Fly  1227 ----------TDKRNVEF-------LDVLIENEQKEVIAH 1249
                      |..|.:||       |...:....|.:..|
  Rat   469 CCSCQMPPGMTSPRFIEFVCKHDEVLKCFVNRNPKIIFDH 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nompC	NP_523483.2	ANK repeat	129..157	CDD:293786
		Ank_2	131..228	CDD:289560
		ANK	155..319	CDD:238125
		ANK repeat	159..186	CDD:293786
		ANK repeat	232..265	CDD:293786
		Ank_2	237..331	CDD:289560
		ANK	263..387	CDD:238125
		ANK repeat	267..298	CDD:293786
		ANK repeat	300..331	CDD:293786
		Ank_2	305..398	CDD:289560
		ANK	329..454	CDD:238125
		ANK repeat	367..398	CDD:293786
		ANK repeat	400..431	CDD:293786
		Ank_2	405..498	CDD:289560
		ANK	428..555	CDD:238125
		ANK repeat	433..463	CDD:293786
		ANK repeat	469..499	CDD:293786
		ANK	496..641	CDD:238125
		ANK repeat	501..532	CDD:293786
		Ank_2	507..616	CDD:289560
		ANK repeat	534..575	CDD:293786
		ANK repeat	577..616	CDD:293786
		Ank_2	625..722	CDD:289560
		ANK	654..780	CDD:238125	12/52 (23%)
		ANK repeat	660..690	CDD:293786
		ANK repeat	692..723	CDD:293786
		Ank_2	697..790	CDD:289560	17/62 (27%)
		ANK	720..847	CDD:238125	33/120 (28%)
		ANK repeat	725..757	CDD:293786	3/18 (17%)
		ANK repeat	759..790	CDD:293786	13/41 (32%)
		Ank_5	779..834	CDD:290568	19/55 (35%)
		ANK	787..915	CDD:238125	34/136 (25%)
		ANK repeat	792..824	CDD:293786	10/32 (31%)
		ANK repeat	861..893	CDD:293786	11/39 (28%)
		Ank_4	865..915	CDD:290365	15/49 (31%)
		Ank_4	929..995	CDD:290365	14/65 (22%)
		ANK repeat	932..972	CDD:293786	9/39 (23%)
		ANK	969..1096	CDD:238125	24/130 (18%)
		ANK repeat	974..1007	CDD:293786	5/32 (16%)
		Ank_2	979..1074	CDD:289560	19/96 (20%)
		ANK repeat	1009..1041	CDD:293786	9/33 (27%)
		ANK	1039..1159	CDD:238125	18/121 (15%)
		ANK repeat	1043..1074	CDD:293786	5/30 (17%)
		Ank_2	1048..1135	CDD:289560	14/88 (16%)
		ANK repeat	1076..1101	CDD:293786	2/24 (8%)
		ANK repeat	1109..1134	CDD:293786	4/24 (17%)
		Ion_trans	<1393..1598	CDD:278921
Hace1	XP_006256657.1	ANK repeat	66..95	CDD:293786	12/28 (43%)
		ANK	66..93	CDD:197603	12/26 (46%)
		Ank_2	69..194	CDD:289560	40/137 (29%)
		ANK	92..217	CDD:238125	34/137 (25%)
		ANK repeat	97..128	CDD:293786	10/32 (31%)
		ANK repeat	130..161	CDD:293786	8/41 (20%)
		Ank_2	135..222	CDD:289560	22/97 (23%)
		ANK repeat	163..194	CDD:293786	9/30 (30%)
		ANK repeat	196..221	CDD:293786	6/24 (25%)
		Ank_4	199..249	CDD:290365	11/50 (22%)
		HECTc	561..910	CDD:238033
		HECTc	586..909	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900