DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nompC and Ank3

DIOPT Version :9

Sequence 1:	NP_523483.2	Gene:	nompC / 33768	FlyBaseID:	FBgn0016920	Length:	1761	Species:	Drosophila melanogaster
Sequence 2:	XP_038954762.1	Gene:	Ank3 / 361833	RGDID:	620157	Length:	4329	Species:	Rattus norvegicus

Alignment Length:	1145	Identity:	310/1145 - (27%)
Similarity:	490/1145 - (42%)	Gaps:	251/1145 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   255 AQTAEQLKAT-----TANGDTALHLAARRRDVDMVRILVDYGTNVDTQNGEGQTPLHIAAAEGDE 314
            |..|.|||..     .|..:|......|:|..|..:           ::....:.|..|.|...|
  Rat     2 AHAASQLKKNRDLEINAEEETEKKKKHRKRSRDRKK-----------KSDANASYLRAARAGHLE 55

  Fly   315 ALLKYF-YGVRASASIADNQDRTPMHLAAENGHAHVIEILADKFKASIFERTKDGSTLMHIASLN 378
            ..|.|. .||  ..:|.:......:|||::.||..|:..|..: :|::...||.|:|.:|||||.
  Rat    56 KALDYIKNGV--DVNICNQNGLNALHLASKEGHVEVVSELLQR-EANVDAATKKGNTALHIASLA 117

  Fly   379 GHAECATMLFKKGVYLHMPNKDGARSIHTAAAYGHTGIINTLLQKGEKVDVTTNDNYTALHIAVE 443
            |.||...:|...|..::..:::|...::.||...|..::..||..|....:.|.|.:|.|.:|::
  Rat   118 GQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVRFLLDNGASQSLATEDGFTPLAVALQ 182

  Fly   444 SAKPAVVETLLGFGADVHVRGGKLRETPLHIAARVKDGDRCALMLLKSGASPNLTTDDCLTPVHV 508
            .....||..||     .:...||:|...|||||| ||..:.|.:||::..:.::.:....||:|:
  Rat   183 QGHDQVVSLLL-----ENDTKGKVRLPALHIAAR-KDDTKAAALLLQNDTNADIESKSGFTPLHI 241

  Fly   509 AARHGNLATLMQLLEDEGDPLYKSNTGETPLHMACRACHPDIVRHLIETVKEKHGPDKATTYINS 573
            ||.:||:.....||.......:.:....||||:|.:..:.::|:.|::...:          |::
  Rat   242 AAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAK----------IDA 296

  Fly   574 VNEDGATALHYTCQITKEEVKIPESDKQIVRMLLENGADVTLQTKTALETAFHYCAVAGNNDVLM 638
            ...||.|.||...:         ...:|:|.|||:..|.:..:||.
  Rat   297 KTRDGLTPLHCGAR---------SGHEQVVEMLLDRAAPILSKTKN------------------- 333

  Fly   639 EMISHMNPTDIQKAMNRQSSVGWTPLLIACHRGHMELVNNLLANHARVDVFDTEGRSALHLAAER 703
                                 |.:||.:|....|:..|..||.::..||....:..:|||:||..
  Rat   334 ---------------------GLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHC 377

  Fly   704 GYLHVCDALLTNKAFINSKSRVGRTALHLAAMNGFTHLVKFLIKDHNAVIDILTLRKQTPLHLAA 768
            |:..|...||..||..|:|           |:|||                       ||||:|.
  Rat   378 GHYKVAKVLLDKKANPNAK-----------ALNGF-----------------------TPLHIAC 408

  Fly   769 ASGQMEVCQLLLELGANIDATDDLGQKPIHVAAQNNYSEVAKLFLQQHPSLVNATSKDGNTCAHI 833
            ...::.|.:|||:.||:|.|..:.|..||||||...:..:... |..|.:..|.|:..|.|..|:
  Rat   409 KKNRIRVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQ-LMHHGASPNTTNVRGETALHM 472

  Fly   834 AAMQGSVKVIEELMKFDRSGVISARNKLTDATPLQLAAEGGHADVVKALVRAGASCTEENKAGFT 898
            ||..|..:|:..|::  ....:.|:.| .|.|||.::|..|.||:|:.|::.|||......:|:|
  Rat   473 AARSGQAEVVRYLVQ--DGAQVEAKAK-DDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYT 534

  Fly   899 AVHLAAQNGHGQVLD-VLKSTNSLRINSKKLGLTPLHVAAYYGQADTVRELLTSVPATVKSETPT 962
            .:||:|:.||..|.. :|....||.|.:|| |.|||||||.||:.:....||.      ||.:|
  Rat   535 PLHLSAREGHEDVAAFLLDHGASLSITTKK-GFTPLHVAAKYGKLEVASLLLQ------KSASP- 591

  Fly   963 GQSLFGDLGTESGMTPLHLAAFSGNENVVRLLLNSAGVQVDAATIENGYNPLHLAC--------- 1018
                  |...:||:||||:||...|:.|..|||:. |....||. :|||.|||:|.
  Rat   592 ------DAAGKSGLTPLHVAAHYDNQKVALLLLDQ-GASPHAAA-KNGYTPLHIAAKKNQMDIAT 648

  Fly  1019 ----FG--------------------GHMSVVGLLLSRSAELLQSQDRNGRTGLHIAAMHGHIQM 1059
                :|                    ||:.:|.|||||:|.:..| :::|.|.||:||....:.:
  Rat   649 SLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLSRNANVNLS-NKSGLTPLHLAAQEDRVNV 712

  Fly  1060 VEILLGQGAEINATDRNGWTPLHCAAKAGHLEVVKLLCEAGASPKSETNYGCAAIWFAASEGHNE 1124
            .|:|:.|||.::|..:.|:||||.....|::::|..|.:..|...::|..|...:..||.:||..
  Rat   713 AEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTH 777

  Fly  1125 VLRYLMNKE--------HDTYGLMEDKRFVY-----NLMVVS-----------KNHNNKP--IQE 1163
            ::..|:...        :....|...:|..|     .|.||:           |:..|.|  :.|
  Rat   778 IINVLLQNNASPNELTVNGNTALAIARRLGYISVVDTLKVVTEEIMTTTTITEKHKMNVPETMNE 842

  Fly  1164 FVLVSPAPVDTAA---KLSNIYIVLSTKEKERA-----------KDLVAAGKQCEAMATE-LLAL 1213
            .:.:|...|..|:   |||:...:...:|.|.|           :||...|.  :::..| .:..
  Rat   843 VLDMSDDEVGKASAPEKLSDGEYISDGEEGEDAITGDTDKYLGPQDLKELGD--DSLPAEGYVGF 905

  Fly  1214 AAGSDSA-------------GKILQATDKRNVEFLDVLIENEQKEVIAHTVVQRYLQELWHGSLT 1265
            :.|:.||             .:...|.|...:|  ::|:.::::.:       .:.:|....||.
  Rat   906 SLGARSASLRSFSSDRSYTLNRSSYARDSMMIE--ELLVPSKEQHL-------PFTREFDSDSLR 961

  Fly  1266 WASWKILLLLVAFIVCPPVWIGFTFPMGHKFNKVPIIKFM 1305
            ..||....|....:|..||..||            ::.||
  Rat   962 HYSWAADTLDNVNLVSSPVHSGF------------LVSFM 989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nompC	NP_523483.2	ANK repeat	129..157	CDD:293786
		Ank_2	131..228	CDD:289560
		ANK	155..319	CDD:238125	15/68 (22%)
		ANK repeat	159..186	CDD:293786
		ANK repeat	232..265	CDD:293786	5/14 (36%)
		Ank_2	237..331	CDD:289560	19/81 (23%)
		ANK	263..387	CDD:238125	34/129 (26%)
		ANK repeat	267..298	CDD:293786	4/30 (13%)
		ANK repeat	300..331	CDD:293786	9/31 (29%)
		Ank_2	305..398	CDD:289560	31/93 (33%)
		ANK	329..454	CDD:238125	37/124 (30%)
		ANK repeat	367..398	CDD:293786	12/30 (40%)
		ANK repeat	400..431	CDD:293786	7/30 (23%)
		Ank_2	405..498	CDD:289560	29/92 (32%)
		ANK	428..555	CDD:238125	38/126 (30%)
		ANK repeat	433..463	CDD:293786	8/29 (28%)
		ANK repeat	469..499	CDD:293786	11/29 (38%)
		ANK	496..641	CDD:238125	30/144 (21%)
		ANK repeat	501..532	CDD:293786	9/30 (30%)
		Ank_2	507..616	CDD:289560	26/108 (24%)
		ANK repeat	534..575	CDD:293786	8/40 (20%)
		ANK repeat	577..616	CDD:293786	11/38 (29%)
		Ank_2	625..722	CDD:289560	22/96 (23%)
		ANK	654..780	CDD:238125	34/125 (27%)
		ANK repeat	660..690	CDD:293786	10/29 (34%)
		ANK repeat	692..723	CDD:293786	12/30 (40%)
		Ank_2	697..790	CDD:289560	29/92 (32%)
		ANK	720..847	CDD:238125	37/126 (29%)
		ANK repeat	725..757	CDD:293786	4/31 (13%)
		ANK repeat	759..790	CDD:293786	13/30 (43%)
		Ank_5	779..834	CDD:290568	20/54 (37%)
		ANK	787..915	CDD:238125	43/128 (34%)
		ANK repeat	792..824	CDD:293786	10/31 (32%)
		ANK repeat	861..893	CDD:293786	13/31 (42%)
		Ank_4	865..915	CDD:290365	20/50 (40%)
		Ank_4	929..995	CDD:290365	27/65 (42%)
		ANK repeat	932..972	CDD:293786	14/39 (36%)
		ANK	969..1096	CDD:238125	54/159 (34%)
		ANK repeat	974..1007	CDD:293786	16/32 (50%)
		Ank_2	979..1074	CDD:289560	42/127 (33%)
		ANK repeat	1009..1041	CDD:293786	18/64 (28%)
		ANK	1039..1159	CDD:238125	36/143 (25%)
		ANK repeat	1043..1074	CDD:293786	12/30 (40%)
		Ank_2	1048..1135	CDD:289560	26/94 (28%)
		ANK repeat	1076..1101	CDD:293786	8/24 (33%)
		ANK repeat	1109..1134	CDD:293786	6/32 (19%)
		Ion_trans	<1393..1598	CDD:278921
Ank3	XP_038954762.1	PHA03095	60..>327	CDD:222980	84/294 (29%)
		ANK repeat	73..104	CDD:293786	8/31 (26%)
		ANK repeat	106..137	CDD:293786	12/30 (40%)
		ANK repeat	139..164	CDD:293786	6/24 (25%)
		Ank_2	195..>429	CDD:423045	83/327 (25%)
		ANK repeat	205..232	CDD:293786	11/27 (41%)
		ANK repeat	234..265	CDD:293786	9/30 (30%)
		ANK repeat	267..298	CDD:293786	8/40 (20%)
		ANK repeat	300..325	CDD:293786	10/33 (30%)
		ANK repeat	333..364	CDD:293786	10/70 (14%)
		PHA03095	369..>657	CDD:222980	118/341 (35%)
		ANK repeat	369..397	CDD:293786	13/38 (34%)
		ANK repeat	399..430	CDD:293786	16/53 (30%)
		ANK repeat	432..463	CDD:293786	10/31 (32%)
		ANK repeat	465..496	CDD:293786	9/32 (28%)
		ANK repeat	498..529	CDD:293786	13/30 (43%)
		ANK repeat	531..560	CDD:293786	11/28 (39%)
		Ank_2	551..>788	CDD:423045	84/253 (33%)
		ANK repeat	564..593	CDD:293786	16/42 (38%)
		ANK repeat	597..626	CDD:293786	14/29 (48%)
		ANK repeat	630..661	CDD:293786	8/30 (27%)
		ANK repeat	663..694	CDD:293786	10/31 (32%)
		ANK repeat	696..727	CDD:293786	12/30 (40%)
		ANK repeat	729..760	CDD:293786	9/30 (30%)
		ANK repeat	762..790	CDD:293786	6/27 (22%)
		Ank_4	763..815	CDD:372654	9/51 (18%)
		ZU5	982..1086	CDD:128514	4/20 (20%)
		UPA_2	1308..1437	CDD:375346
		Herpes_BLLF1	<1477..1879	CDD:282904
		PTZ00449	<2044..2316	CDD:185628
		DUF2890	3229..>3350	CDD:314108
		Death_ank3	4041..4124	CDD:176781
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910