DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nompC and asb3

DIOPT Version :9

Sequence 1:NP_523483.2 Gene:nompC / 33768 FlyBaseID:FBgn0016920 Length:1761 Species:Drosophila melanogaster
Sequence 2:NP_956168.1 Gene:asb3 / 334210 ZFINID:ZDB-GENE-030131-6142 Length:519 Species:Danio rerio


Alignment Length:558 Identity:126/558 - (22%)
Similarity:215/558 - (38%) Gaps:162/558 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   869 LAAEGGHADVVKALVRAGASCTEENKAGFTAVHLAAQNGHGQVLDVL--------KSTNSLRINS 925
            |||..|.:..|:.|:|.|.:...::..|:.|:|.||..|....:.:|        ...|:|..||
Zfish    16 LAARDGKSRRVQKLIRRGFAVDVKDNRGWNALHEAAAAGTAGCVRLLIPAAVNCEDYVNTLTHNS 80

  Fly   926 KKLGLTPLHVAAYYGQADTVRELLTSVPATVKSETPTGQSLFGDLGTESGMTPLHLAAFSGNENV 990
            :    |||:.||.||....|:.|: ...|.:..:|       .||.     .||:.|...|:::|
Zfish    81 E----TPLYFAAKYGHLRAVKWLI-KAGADINRKT-------NDLS-----CPLYAAVDGGHKDV 128

  Fly   991 VRLLLNSAGVQVDAATIENGYNPLHLACFGGHMSVVGLLLSRSAELLQSQDRNGRTGLHIAAMHG 1055
            :.||:.: |.:|:.....:|::.||.|.:.||:.:|..|:|...  |::.|..|.|.|.:||.:|
Zfish   129 IELLVRN-GAEVNGTYSLSGWSCLHQAVYKGHIEIVRYLVSLCT--LEAVDDYGITPLFVAAQYG 190

  Fly  1056 HIQMVEILLGQGAEINATDRNGWTPLHCAAKAGHLEVVKLLCEAGASPKSETNYGC--------- 1111
            |.|.::||...||.:|....:..|||..||:.||.:.|:.|...||.|....|..|         
Zfish   191 HHQCLDILANAGANVNCQANDLATPLLIAAQEGHEQCVECLLAHGADPNLYCNEYCWQLPILAAA 255

  Fly  1112 --------------------------AAIWFAASEGHNEVLRYLMNKEHDTYGLMED----KRFV 1146
                                      :.::.|...||.:.||.|:.|     |...|    .:|.
Zfish   256 QFNRLSILEKLISVTKRECDRGEGKVSPVYLAVLGGHADSLRALLQK-----GYSPDAQSCPQFG 315

  Fly  1147 YN-----------------------------LMVVSKNHNNKPIQEFVLVSPAPVDTAAKLSNIY 1182
            |:                             :::.:..|.|..|..|.|....|       .::.
Zfish   316 YSCPLEMALWTWLDASWNLNSECHQAQEITLILLAAGAHVNTSIYGFTLQGHVP-------EHLP 373

  Fly  1183 IVL---STKEKERAKDLVAAGKQCEAMATEL--------LALAAGSDSAGKILQATDKRNVEFLD 1236
            ::|   ...:.:|.::|:      :...||:        |.|.||.|..                
Zfish   374 LILKHAGLPQGDRLRELI------DRALTEVKDASFWLPLLLKAGLDPM---------------- 416

  Fly  1237 VLIENEQKEVIAHTVVQRYLQELWHGSLTWASWKIL----LLLVAFIVCPPVWIGFTFPMGHKFN 1297
            :|::::..|...:..:..:|:        :.:||.|    |.::|.......|.    |..| |.
Zfish   417 LLLQDKLLEEAGNDALNFFLE--------FVNWKTLPSEMLQILAHRRAEGTWT----PRKH-FE 468

  Fly  1298 KVPIIKFMSYLT--SHI--YLMIHLSIVGITPIYPVLR 1331
            .||::..:..|.  :|:  ..:...|.:.:.||..:|:
Zfish   469 SVPVLAHLCRLAVGAHVGSDTLSKPSFIQLLPIPSLLQ 506

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nompCNP_523483.2 ANK repeat 129..157 CDD:293786
Ank_2 131..228 CDD:289560
ANK 155..319 CDD:238125
ANK repeat 159..186 CDD:293786
ANK repeat 232..265 CDD:293786
Ank_2 237..331 CDD:289560
ANK 263..387 CDD:238125
ANK repeat 267..298 CDD:293786
ANK repeat 300..331 CDD:293786
Ank_2 305..398 CDD:289560
ANK 329..454 CDD:238125
ANK repeat 367..398 CDD:293786
ANK repeat 400..431 CDD:293786
Ank_2 405..498 CDD:289560
ANK 428..555 CDD:238125
ANK repeat 433..463 CDD:293786
ANK repeat 469..499 CDD:293786
ANK 496..641 CDD:238125
ANK repeat 501..532 CDD:293786
Ank_2 507..616 CDD:289560
ANK repeat 534..575 CDD:293786
ANK repeat 577..616 CDD:293786
Ank_2 625..722 CDD:289560
ANK 654..780 CDD:238125
ANK repeat 660..690 CDD:293786
ANK repeat 692..723 CDD:293786
Ank_2 697..790 CDD:289560
ANK 720..847 CDD:238125
ANK repeat 725..757 CDD:293786
ANK repeat 759..790 CDD:293786
Ank_5 779..834 CDD:290568
ANK 787..915 CDD:238125 14/45 (31%)
ANK repeat 792..824 CDD:293786
ANK repeat 861..893 CDD:293786 8/23 (35%)
Ank_4 865..915 CDD:290365 14/45 (31%)
Ank_4 929..995 CDD:290365 19/65 (29%)
ANK repeat 932..972 CDD:293786 12/39 (31%)
ANK 969..1096 CDD:238125 43/126 (34%)
ANK repeat 974..1007 CDD:293786 9/32 (28%)
Ank_2 979..1074 CDD:289560 32/94 (34%)
ANK repeat 1009..1041 CDD:293786 10/31 (32%)
ANK 1039..1159 CDD:238125 40/187 (21%)
ANK repeat 1043..1074 CDD:293786 13/30 (43%)
Ank_2 1048..1135 CDD:289560 32/121 (26%)
ANK repeat 1076..1101 CDD:293786 9/24 (38%)
ANK repeat 1109..1134 CDD:293786 8/59 (14%)
Ion_trans <1393..1598 CDD:278921
asb3NP_956168.1 ANK <2..100 CDD:238125 27/87 (31%)
ANK repeat 9..40 CDD:293786 8/23 (35%)
Ank_2 16..109 CDD:289560 29/97 (30%)
ANK repeat 42..77 CDD:293786 8/34 (24%)
ANK 74..198 CDD:238125 45/143 (31%)
ANK repeat 79..110 CDD:293786 12/35 (34%)
ANK repeat 112..140 CDD:293786 10/33 (30%)
ANK repeat 146..176 CDD:293786 10/31 (32%)
ANK 147..267 CDD:238125 38/121 (31%)
Ank_2 151..240 CDD:289560 35/90 (39%)
ANK repeat 178..209 CDD:293786 13/30 (43%)
ANK repeat 211..240 CDD:293786 12/28 (43%)
Ank_4 214..267 CDD:290365 14/52 (27%)
Ank_2 216..356 CDD:289560 24/144 (17%)
ANK repeat 279..309 CDD:293786 9/34 (26%)
SOCS_ASB3 468..518 CDD:239692 8/39 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24121
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.100

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