DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nompC and Invs

DIOPT Version :9

Sequence 1:NP_523483.2 Gene:nompC / 33768 FlyBaseID:FBgn0016920 Length:1761 Species:Drosophila melanogaster
Sequence 2:XP_038965783.1 Gene:Invs / 313228 RGDID:1563359 Length:1077 Species:Rattus norvegicus


Alignment Length:686 Identity:185/686 - (26%)
Similarity:295/686 - (43%) Gaps:106/686 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   609 NGADVTLQTKTALETAFHYCAVAGNNDVLMEMISHMNPTDIQKAMNRQSSVGWTPLLIACHRGHM 673
            |.::..|.|.::|.:..|..||.|:...|..:|     .......:::...|.|||:.......:
  Rat     2 NISENVLSTGSSLASQVHAAAVNGDKGALQRLI-----VGNSALKDKEDQFGRTPLMYCVLADRL 61

  Fly   674 ELVNNLLANHARVDVFDTEGRSALHLAAERGYLHVCDALLTNKAFINSKSRVGRTALHLAAMNG- 737
            :..:.||...|.|:..|...|:||||||::|.......|||.:|....|.....|.|||:..:. 
  Rat    62 DCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRS 126

  Fly   738 ---FTHLVKFLIKDHNAVIDILTLRKQTPLHLAAASGQMEVCQLLLELGANIDATDDLGQKPIHV 799
               ...|:||:....   :|.....|||.||.:|.....|..:||::..:||...|..|:.|:|.
  Rat   127 PKCLALLLKFMAPGE---VDTQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHW 188

  Fly   800 AAQNNYSEVA-----KLFLQQHP--SLVNATSKDGNTCAHIAAMQGSVKVIEELMKFDRSGVISA 857
            ||  |:.:.:     :..|...|  ||:|....:|.|..|.|...|::.|::.|..::...:.|.
  Rat   189 AA--NHKDASAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNLTVVDVLTSYESCNITSY 251

  Fly   858 RNKLTDATPLQLAAEGGHADVVKALVRAGASCT-EENKAGFTAVHLAAQNG------HG------ 909
            .|..  .|||..||..|||.:|..|:....|.| ..:..|.|.:|.|||:.      ||      
  Rat   252 DNLF--RTPLHWAALLGHAQIVHLLLERNKSGTVPSDSQGATPLHYAAQSNFAVLHYHGPDVPHH 314

  Fly   910 ----------QVLDVLKSTNSLRINSKKLGLTPLHVAAYYGQADTVRELLTSVPATVKSETPTGQ 964
                      :.:.|..:..|:|.:|...|.|....||..|..|.:|.:|     ::||:...  
  Rat   315 CAVSNKVFLQETVKVFLTHPSVRDDSDLEGRTSFMWAAGKGSDDVLRTML-----SLKSDIDI-- 372

  Fly   965 SLFGDLGTESGMTPLHLAAFSGNENVVRLLLNSAGVQVDAATIENGYNPLHLACFGGHMSVVGLL 1029
                ::..:.|.|.||.||.||:.:.|:|||:: ..||||..:.. :.||..||..||..|:..|
  Rat   373 ----NMADKYGGTALHAAALSGHVSTVKLLLDN-DAQVDATDVMK-HTPLFRACEMGHRDVIQTL 431

  Fly  1030 LSRSAELLQSQDRNGRTGLHIAAMHGHIQMVEILLGQGAEINATDRNGWTPLHCAAKAGHLEVVK 1094
            :...|. :...|::|.:.||.||:.|:..:.:||:......|..|..|.|||.|||..|::..:.
  Rat   432 IKGGAR-VDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMA 495

  Fly  1095 LLCEAGASPKSETNYGCAAIWFAASEGHNEVLRYLM-----------NKEHDT---YGLMEDKRF 1145
            :|.|..|.|..:...|..|:.::.:.|:.:.::.|:           |:|..|   |.|:.::..
  Rat   496 VLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHE 560

  Fly  1146 VYNLMVVSKNHNNKPIQEFVLVSPAPVDTAA-KLSNIYIVLSTKEKER-AKDLVAAGKQCEAMAT 1208
            |...|          ::...|...|..|.|| |:..:|.....::..| .|:|:...:|..    
  Rat   561 VIQFM----------LEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLR---- 611

  Fly  1209 ELLALAAGSDSAGKILQATDKRNVEFLDVLIENEQK 1244
                    .|:|.|..:..:||.        |.|||
  Rat   612 --------KDAAAKKREEENKRK--------EAEQK 631

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nompCNP_523483.2 ANK repeat 129..157 CDD:293786
Ank_2 131..228 CDD:289560
ANK 155..319 CDD:238125
ANK repeat 159..186 CDD:293786
ANK repeat 232..265 CDD:293786
Ank_2 237..331 CDD:289560
ANK 263..387 CDD:238125
ANK repeat 267..298 CDD:293786
ANK repeat 300..331 CDD:293786
Ank_2 305..398 CDD:289560
ANK 329..454 CDD:238125
ANK repeat 367..398 CDD:293786
ANK repeat 400..431 CDD:293786
Ank_2 405..498 CDD:289560
ANK 428..555 CDD:238125
ANK repeat 433..463 CDD:293786
ANK repeat 469..499 CDD:293786
ANK 496..641 CDD:238125 9/31 (29%)
ANK repeat 501..532 CDD:293786
Ank_2 507..616 CDD:289560 1/6 (17%)
ANK repeat 534..575 CDD:293786
ANK repeat 577..616 CDD:293786 1/6 (17%)
Ank_2 625..722 CDD:289560 27/96 (28%)
ANK 654..780 CDD:238125 38/129 (29%)
ANK repeat 660..690 CDD:293786 8/29 (28%)
ANK repeat 692..723 CDD:293786 12/30 (40%)
Ank_2 697..790 CDD:289560 30/96 (31%)
ANK 720..847 CDD:238125 38/137 (28%)
ANK repeat 725..757 CDD:293786 8/35 (23%)
ANK repeat 759..790 CDD:293786 11/30 (37%)
Ank_5 779..834 CDD:290568 18/61 (30%)
ANK 787..915 CDD:238125 41/157 (26%)
ANK repeat 792..824 CDD:293786 11/38 (29%)
ANK repeat 861..893 CDD:293786 12/32 (38%)
Ank_4 865..915 CDD:290365 20/72 (28%)
Ank_4 929..995 CDD:290365 20/65 (31%)
ANK repeat 932..972 CDD:293786 8/39 (21%)
ANK 969..1096 CDD:238125 44/126 (35%)
ANK repeat 974..1007 CDD:293786 16/32 (50%)
Ank_2 979..1074 CDD:289560 33/94 (35%)
ANK repeat 1009..1041 CDD:293786 9/31 (29%)
ANK 1039..1159 CDD:238125 34/133 (26%)
ANK repeat 1043..1074 CDD:293786 9/30 (30%)
Ank_2 1048..1135 CDD:289560 27/97 (28%)
ANK repeat 1076..1101 CDD:293786 10/24 (42%)
ANK repeat 1109..1134 CDD:293786 5/35 (14%)
Ion_trans <1393..1598 CDD:278921
InvsXP_038965783.1 Ank_5 33..88 CDD:404699 14/59 (24%)
ANK repeat 47..78 CDD:293786 8/30 (27%)
PHA02874 <62..>262 CDD:165205 61/206 (30%)
ANK repeat 80..111 CDD:293786 12/30 (40%)
ANK repeat 113..146 CDD:293786 8/35 (23%)
ANK repeat 150..179 CDD:293786 10/28 (36%)
ANK repeat 181..218 CDD:293786 11/38 (29%)
ANK repeat 220..252 CDD:293786 8/31 (26%)
ANKYR <252..400 CDD:223738 46/160 (29%)
ANK repeat 254..286 CDD:293786 12/33 (36%)
ANK repeat 343..376 CDD:293786 10/43 (23%)
Ank_2 358..>576 CDD:423045 65/241 (27%)
ANK repeat 378..409 CDD:293786 16/31 (52%)
ANK repeat 411..442 CDD:293786 9/32 (28%)
ANK repeat 444..475 CDD:293786 9/30 (30%)
ANK repeat 477..508 CDD:293786 12/30 (40%)
ANK repeat 510..538 CDD:293786 4/27 (15%)
ANK repeat 543..570 CDD:293786 7/36 (19%)
PHA03307 634..>899 CDD:223039
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
10.960

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