DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nompC and ANK3

DIOPT Version :9

Sequence 1:NP_523483.2 Gene:nompC / 33768 FlyBaseID:FBgn0016920 Length:1761 Species:Drosophila melanogaster
Sequence 2:NP_066267.2 Gene:ANK3 / 288 HGNCID:494 Length:4377 Species:Homo sapiens


Alignment Length:1149 Identity:300/1149 - (26%)
Similarity:472/1149 - (41%) Gaps:288/1149 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   222 GKDIRLKADGRGKIPLLLAVESGNQSMCRELLAAQTAEQLKATTANGDTALHLAARRRDVDMVRI 286
            |.||.: .:..|...|.||.:.|:..:..|||  |....:.|.|..|:||||:|:.....::|::
Human    64 GVDINI-CNQNGLNALHLASKEGHVEVVSELL--QREANVDAATKKGNTALHIASLAGQAEVVKV 125

  Fly   287 LVDYGTNVDTQNGEGQTPLHIAAAEGDEALLKYFYGVRASASIADNQDRTPMHLAAENGHAHVIE 351
            ||..|.||:.|:..|.|||::||.|....::|:.....||.|:|.....||:.:|.:.||..|:.
Human   126 LVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVS 190

  Fly   352 IL-------------------ADKFKASIF---------ERTKDGSTLMHIASLNGHAECATMLF 388
            :|                   .|..||:..         ..:|.|.|.:|||:..|:...||:|.
Human   191 LLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLL 255

  Fly   389 KKGVYLHMPNKDGARSIHTAAAYGHTGIINTLLQKGEKVDVTTNDNYTALHIAVESAKPAVVETL 453
            .:...:....::....:|.|:..|:..::..||.:|.|:|..|.|..|.||....|....|||.|
Human   256 NRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEML 320

  Fly   454 LGFGADV--HVRGGKLRETPLHIAARVKDGD--RCALMLLKSGASPNLTTDDCLTPVHVAARHGN 514
            |...|.:  ..:.|.   :|||:|.:   ||  .|..:||:.....:..|:|.||.:||||..|:
Human   321 LDRAAPILSKTKNGL---SPLHMATQ---GDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGH 379

  Fly   515 LATLMQLLEDEGDPLYKSNTGETPLHMACRACHPDIVRHLIETVKEKHGPDKATTYINSVNEDGA 579
            ......||:.:.:|..|:..|.||||:||:                                   
Human   380 YKVAKVLLDKKANPNAKALNGFTPLHIACK----------------------------------- 409

  Fly   580 TALHYTCQITKEEVKIPESDKQIVRMLLENGADVTLQTKTALETAFHYCAVAGNNDVLMEMISH- 643
                      |..:|:.|       :||::||.:...|::.| |..|..|..|:.:::.:::.| 
Human   410 ----------KNRIKVME-------LLLKHGASIQAVTESGL-TPIHVAAFMGHVNIVSQLMHHG 456

  Fly   644 --MNPTDIQKAMNRQSSVGWTPLLIACHRGHMELVNNLLANHARVDVFDTEGRSALHLAAERGYL 706
              .|.|:::         |.|.|.:|...|..|:|..|:.:.|:|:....:.::.||::|..|..
Human   457 ASPNTTNVR---------GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKA 512

  Fly   707 HVCDALLTNKAFINSKSRVGRTALHLAAMNGFTHLVKFLIKDHNAVIDILTLRKQTPLHLAAASG 771
            .:...||...|..|:.:..|.|.|||:|..|...:..||: ||.|.:.|.|.:..||||:||..|
Human   513 DIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLL-DHGASLSITTKKGFTPLHVAAKYG 576

  Fly   772 QMEVCQLLLELGANIDATDDLGQKPIHVAAQNNYSEVAKLFLQQHPSLVNATSKDGNTCAHIAAM 836
            ::||..|||:..|:.||....|..|:||||..:..:||.|.|.|..|            .|.||.
Human   577 KLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGAS------------PHAAAK 629

  Fly   837 QGSVKVIEELMKFDRSGVISARNKLTDATPLQLAAEGGHADVVKALVRAGASCTEENKAGFTAVH 901
            .|                         .|||.:||:....|:...|:..||......:.|..:||
Human   630 NG-------------------------YTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVH 669

  Fly   902 LAAQNGHGQVLDVLKSTNSLRINSKKLGLTPLHVAAYYGQADTVRELLTSVPATVKSETPTGQSL 966
            ||||.||..::.:|...|: .:|                                          
Human   670 LAAQEGHVDMVSLLLGRNA-NVN------------------------------------------ 691

  Fly   967 FGDLGTESGMTPLHLAAFSGNENVVRLLLNSAGVQVDAATIENGYNPLHLACFGGHMSVVGLLLS 1031
               |..:||:|||||||.....||..:|:|. |..|||.| :.||.|||:.|.            
Human   692 ---LSNKSGLTPLHLAAQEDRVNVAEVLVNQ-GAHVDAQT-KMGYTPLHVGCH------------ 739

  Fly  1032 RSAELLQSQDRNGRTGLHIAAMHGHIQMVEILLGQGAEINATDRNGWTPLHCAAKAGHLEVVKLL 1096
                                  :|:|::|..||...|::||..:||:||||.||:.||..::.:|
Human   740 ----------------------YGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVL 782

  Fly  1097 CEAGASPKSETNYGCAAIWFAASEGHNEVLRYLMNKEHDTYGLMEDKRFVYNLMVVSKNHNNKP- 1160
            .:..|||...|..|..|:..|...|:..|:        ||..::.::... ...|..|:..|.| 
Human   783 LQNNASPNELTVNGNTALGIARRLGYISVV--------DTLKIVTEETMT-TTTVTEKHKMNVPE 838

  Fly  1161 -IQEFVLVSPAPVDTA---AKLSNIYIVLSTKEKERA-----------KDLVAAGKQCEAMATE- 1209
             :.|.:.:|...|..|   ..||:...:...:|.|.|           :||...|.  :::..| 
Human   839 TMNEVLDMSDDEVRKANAPEMLSDGEYISDVEEGEDAMTGDTDKYLGPQDLKELGD--DSLPAEG 901

  Fly  1210 LLALAAGSDSA-------------GKILQATDKRNVEFLDVLIENEQKEVIAHTVVQRYLQELWH 1261
            .:..:.|:.||             .:...|.|...:|  ::|:.::::.:       .:.:|...
Human   902 YMGFSLGARSASLRSFSSDRSYTLNRSSYARDSMMIE--ELLVPSKEQHL-------TFTREFDS 957

  Fly  1262 GSLTWASWKILLLLVAFIVCPPVWIGFTFPMGHKFNKVPIIKFM 1305
            .||...||....|....:|..|:..||            ::.||
Human   958 DSLRHYSWAADTLDNVNLVSSPIHSGF------------LVSFM 989

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nompCNP_523483.2 ANK repeat 129..157 CDD:293786
Ank_2 131..228 CDD:289560 3/5 (60%)
ANK 155..319 CDD:238125 34/96 (35%)
ANK repeat 159..186 CDD:293786
ANK repeat 232..265 CDD:293786 10/32 (31%)
Ank_2 237..331 CDD:289560 34/93 (37%)
ANK 263..387 CDD:238125 46/151 (30%)
ANK repeat 267..298 CDD:293786 12/30 (40%)
ANK repeat 300..331 CDD:293786 11/30 (37%)
Ank_2 305..398 CDD:289560 29/120 (24%)
ANK 329..454 CDD:238125 38/152 (25%)
ANK repeat 367..398 CDD:293786 9/30 (30%)
ANK repeat 400..431 CDD:293786 8/30 (27%)
Ank_2 405..498 CDD:289560 30/96 (31%)
ANK 428..555 CDD:238125 43/130 (33%)
ANK repeat 433..463 CDD:293786 11/31 (35%)
ANK repeat 469..499 CDD:293786 9/31 (29%)
ANK 496..641 CDD:238125 33/144 (23%)
ANK repeat 501..532 CDD:293786 11/30 (37%)
Ank_2 507..616 CDD:289560 23/108 (21%)
ANK repeat 534..575 CDD:293786 7/40 (18%)
ANK repeat 577..616 CDD:293786 7/38 (18%)
Ank_2 625..722 CDD:289560 24/99 (24%)
ANK 654..780 CDD:238125 42/125 (34%)
ANK repeat 660..690 CDD:293786 10/29 (34%)
ANK repeat 692..723 CDD:293786 8/30 (27%)
Ank_2 697..790 CDD:289560 37/92 (40%)
ANK 720..847 CDD:238125 46/126 (37%)
ANK repeat 725..757 CDD:293786 13/31 (42%)
ANK repeat 759..790 CDD:293786 15/30 (50%)
Ank_5 779..834 CDD:290568 18/54 (33%)
ANK 787..915 CDD:238125 36/127 (28%)
ANK repeat 792..824 CDD:293786 12/31 (39%)
ANK repeat 861..893 CDD:293786 9/31 (29%)
Ank_4 865..915 CDD:290365 18/49 (37%)
Ank_4 929..995 CDD:290365 12/65 (18%)
ANK repeat 932..972 CDD:293786 1/39 (3%)
ANK 969..1096 CDD:238125 43/126 (34%)
ANK repeat 974..1007 CDD:293786 17/32 (53%)
Ank_2 979..1074 CDD:289560 28/94 (30%)
ANK repeat 1009..1041 CDD:293786 6/31 (19%)
ANK 1039..1159 CDD:238125 32/119 (27%)
ANK repeat 1043..1074 CDD:293786 8/30 (27%)
Ank_2 1048..1135 CDD:289560 28/86 (33%)
ANK repeat 1076..1101 CDD:293786 11/24 (46%)
ANK repeat 1109..1134 CDD:293786 5/24 (21%)
Ion_trans <1393..1598 CDD:278921
ANK3NP_066267.2 ANK 6 234..263 9/28 (32%)
ANK repeat 267..298 CDD:293786 8/30 (27%)
ANK 7 267..296 7/28 (25%)
Ank_2 272..363 CDD:289560 30/96 (31%)
ANK 295..420 CDD:238125 46/182 (25%)
ANK 8 300..329 11/28 (39%)
ANK repeat 300..325 CDD:293786 10/24 (42%)
ANK repeat 333..364 CDD:293786 10/36 (28%)
ANK 9 333..362 10/34 (29%)
ANK 361..486 CDD:238125 43/186 (23%)
ANK 10 366..395 11/28 (39%)
ANK repeat 369..397 CDD:293786 9/27 (33%)
Ank_2 371..463 CDD:289560 31/144 (22%)
ANK repeat 399..430 CDD:293786 14/82 (17%)
ANK 11 399..428 14/80 (18%)
ANK repeat 432..463 CDD:293786 7/31 (23%)
ANK 12 432..461 6/29 (21%)
ANK 460..585 CDD:238125 44/134 (33%)
ANK repeat 465..496 CDD:293786 10/39 (26%)
ANK 13 465..494 10/37 (27%)
Ank_2 470..561 CDD:289560 28/91 (31%)
ANK repeat 498..529 CDD:293786 8/30 (27%)
ANK 14 498..527 7/28 (25%)
ANK repeat 531..560 CDD:293786 12/29 (41%)
ANK 15 531..560 12/29 (41%)
Ank_2 536..626 CDD:289560 39/102 (38%)
ANK 560..684 CDD:238125 51/160 (32%)
ANK repeat 564..593 CDD:293786 13/28 (46%)
ANK 16 564..593 13/28 (46%)
ANK repeat 597..626 CDD:293786 12/40 (30%)
ANK 17 597..626 12/40 (30%)
ANK repeat 630..660 CDD:293786 10/54 (19%)
ANK 18 630..659 10/53 (19%)
Ank_4 631..684 CDD:290365 19/77 (25%)
ANK 658..783 CDD:238125 55/206 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..44
Ank_4 47..94 CDD:290365 9/30 (30%)
ANK 68..193 CDD:238125 42/127 (33%)
ANK repeat 73..104 CDD:293786 10/32 (31%)
ANK 1 73..102 9/30 (30%)
Ank_2 78..164 CDD:289560 31/87 (36%)
ANK repeat 106..137 CDD:293786 12/30 (40%)
ANK 2 106..135 12/28 (43%)
ANK 3 139..168 10/28 (36%)
ANK repeat 139..164 CDD:293786 8/24 (33%)
Ank_4 140..193 CDD:290365 18/52 (35%)
ANK 4 172..201 7/28 (25%)
ANK 5 203..230 3/26 (12%)
ANK repeat 205..232 CDD:293786 3/26 (12%)
Ank_2 206..297 CDD:289560 21/90 (23%)
ANK 229..354 CDD:238125 38/130 (29%)
ANK repeat 234..265 CDD:293786 9/30 (30%)
ANK repeat 663..694 CDD:293786 13/76 (17%)
ANK 19 663..692 12/74 (16%)
Ank_2 669..759 CDD:289560 42/171 (25%)
ANK repeat 696..727 CDD:293786 17/31 (55%)
ANK 20 696..725 15/29 (52%)
ANK repeat 729..760 CDD:293786 14/64 (22%)
ANK 21 729..758 12/62 (19%)
Ank_5 749..803 CDD:290568 22/53 (42%)
ANK 22 762..791 14/28 (50%)
ANK repeat 762..790 CDD:293786 13/27 (48%)
ANK 23 795..825 7/38 (18%)
ZU5 982..1086 CDD:128514 4/20 (20%)
UPA domain. /evidence=ECO:0000250 1273..1407
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1519..1540
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1968..1987
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2107..2159
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2176..2245
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2299..2322
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2383..2433
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2474..2508
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2588..2751
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2795..2824
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3036..3067
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3131..3272
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3298..3516
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3538..3607
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3635..3718
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3868..3897
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4019..4090
Death_ank3 4088..4171 CDD:176781
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4251..4298
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4323..4377
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.