DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nompC and INVS

DIOPT Version :9

Sequence 1:	NP_523483.2	Gene:	nompC / 33768	FlyBaseID:	FBgn0016920	Length:	1761	Species:	Drosophila melanogaster
Sequence 2:	NP_055240.2	Gene:	INVS / 27130	HGNCID:	17870	Length:	1065	Species:	Homo sapiens

Alignment Length:	665	Identity:	181/665 - (27%)
Similarity:	289/665 - (43%)	Gaps:	84/665 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   609 NGADVTLQTKTALETAFHYCAVAGNNDVLMEMISHMNPTDIQKAMNRQSSVGWTPLLIACHRGHM 673
            |.::..|...::|.:..|..||.|:...|..:|     .......:::...|.|||:.......:
Human     2 NKSENLLFAGSSLASQVHAAAVNGDKGALQRLI-----VGNSALKDKEDQFGRTPLMYCVLADRL 61

  Fly   674 ELVNNLLANHARVDVFDTEGRSALHLAAERGYLHVCDALLTNKAFINSKSRVGRTALHLAAMNG- 737
            :..:.||...|.|:..|...|:||||||::|.......|||.:|....|.....|.|||...:.
Human    62 DCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRS 126

  Fly   738 ---FTHLVKFLIKDHNAVIDILTLRKQTPLHLAAASGQMEVCQLLLELGANIDATDDLGQKPIHV 799
               ...|:||:....   :|.....|||.||.:|.....|..:||::..:||...|..|:.|:|.
Human   127 PKCLALLLKFMAPGE---VDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHW 188

  Fly   800 AAQNNYSE-----VAKLFLQQHP--SLVNATSKDGNTCAHIAAMQGSVKVIEELMKFDRSGVISA 857
            ||  |:.:     ..:..|...|  ||:|....:|.|..|.|...|:|.|::.|..::...:.|.
Human   189 AA--NHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSY 251

  Fly   858 RNKLTDATPLQLAAEGGHADVVKALVRAGASCT-EENKAGFTAVHLAAQNGHGQVLDVLKSTNSL 921
            .|..  .|||..||..|||.:|..|:....|.| ..:..|.|.:|.|||:...:.:.|.....|:
Human   252 DNLF--RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSV 314

  Fly   922 RINSKKLGLTPLHVAAYYGQADTVRELLTSVPATVKSETPTGQSLFGDLGTESGMTPLHLAAFSG 986
            :.:|...|.|....||..|..|.:|.:|     ::||:...      ::..:.|.|.||.||.||
Human   315 KDDSDLEGRTSFMWAAGKGSDDVLRTML-----SLKSDIDI------NMADKYGGTALHAAALSG 368

  Fly   987 NENVVRLLLNSAGVQVDAATIENGYNPLHLACFGGHMSVVGLLLSRSAELLQSQDRNGRTGLHIA 1051
            :.:.|:|||.: ..||||..:.. :.||..||..||..|:..|:...|. :...|::|.:.||.|
Human   369 HVSTVKLLLEN-NAQVDATDVMK-HTPLFRACEMGHKDVIQTLIKGGAR-VDLVDQDGHSLLHWA 430

  Fly  1052 AMHGHIQMVEILLGQGAEINATDRNGWTPLHCAAKAGHLEVVKLLCEAGASPKSETNYGCAAIWF 1116
            |:.|:..:.:||:......|..|..|.|||.|||..|::..:.:|.|..|.|..:...|..|:.:
Human   431 ALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHW 495

  Fly  1117 AASEGHNEVLRYLM-----------NKEHDT---YGLMEDKRFVYNLMVVSKNHNNKPIQEFVLV 1167
            :.:.|:.:.::.|:           |:|..|   |.|:.::..|...|          ::...|.
Human   496 SCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFM----------LEHGALS 550

  Fly  1168 SPAPVDTAA-KLSNIYIVLSTKEKER-AKDLVAAGKQCEAMATELLALAAGSDSAGKILQATDKR 1230
            ..|..|.|| |:..:|.....::..| .|:|:...:|..            .|:|.|..:..:||
Human   551 IAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLR------------KDAAAKKREEENKR 603

  Fly  1231 NVEFLDVLIENEQKE 1245
            .        |.||::
Human   604 K--------EAEQQK 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nompC	NP_523483.2	ANK repeat	129..157	CDD:293786
		Ank_2	131..228	CDD:289560
		ANK	155..319	CDD:238125
		ANK repeat	159..186	CDD:293786
		ANK repeat	232..265	CDD:293786
		Ank_2	237..331	CDD:289560
		ANK	263..387	CDD:238125
		ANK repeat	267..298	CDD:293786
		ANK repeat	300..331	CDD:293786
		Ank_2	305..398	CDD:289560
		ANK	329..454	CDD:238125
		ANK repeat	367..398	CDD:293786
		ANK repeat	400..431	CDD:293786
		Ank_2	405..498	CDD:289560
		ANK	428..555	CDD:238125
		ANK repeat	433..463	CDD:293786
		ANK repeat	469..499	CDD:293786
		ANK	496..641	CDD:238125	8/31 (26%)
		ANK repeat	501..532	CDD:293786
		Ank_2	507..616	CDD:289560	1/6 (17%)
		ANK repeat	534..575	CDD:293786
		ANK repeat	577..616	CDD:293786	1/6 (17%)
		Ank_2	625..722	CDD:289560	27/96 (28%)
		ANK	654..780	CDD:238125	38/129 (29%)
		ANK repeat	660..690	CDD:293786	8/29 (28%)
		ANK repeat	692..723	CDD:293786	12/30 (40%)
		Ank_2	697..790	CDD:289560	30/96 (31%)
		ANK	720..847	CDD:238125	39/137 (28%)
		ANK repeat	725..757	CDD:293786	8/35 (23%)
		ANK repeat	759..790	CDD:293786	11/30 (37%)
		Ank_5	779..834	CDD:290568	18/61 (30%)
		ANK	787..915	CDD:238125	40/135 (30%)
		ANK repeat	792..824	CDD:293786	11/38 (29%)
		ANK repeat	861..893	CDD:293786	12/32 (38%)
		Ank_4	865..915	CDD:290365	18/50 (36%)
		Ank_4	929..995	CDD:290365	20/65 (31%)
		ANK repeat	932..972	CDD:293786	8/39 (21%)
		ANK	969..1096	CDD:238125	44/126 (35%)
		ANK repeat	974..1007	CDD:293786	16/32 (50%)
		Ank_2	979..1074	CDD:289560	33/94 (35%)
		ANK repeat	1009..1041	CDD:293786	9/31 (29%)
		ANK	1039..1159	CDD:238125	34/133 (26%)
		ANK repeat	1043..1074	CDD:293786	9/30 (30%)
		Ank_2	1048..1135	CDD:289560	27/97 (28%)
		ANK repeat	1076..1101	CDD:293786	10/24 (42%)
		ANK repeat	1109..1134	CDD:293786	5/35 (14%)
		Ion_trans	<1393..1598	CDD:278921
INVS	NP_055240.2	ANK 1	13..42		7/33 (21%)
		Ank_2	19..111	CDD:289560	27/96 (28%)
		ANK	42..169	CDD:238125	38/129 (29%)
		ANK repeat	47..78	CDD:293786	8/30 (27%)
		ANK 2	47..76		8/28 (29%)
		ANK repeat	80..146	CDD:293786	21/68 (31%)
		ANK 3	80..110		12/29 (41%)
		Ank_2	85..179	CDD:289560	30/96 (31%)
		ANK 4	113..144		7/33 (21%)
		ANK	143..309	CDD:238125	53/169 (31%)
		ANK repeat	148..179	CDD:293786	11/30 (37%)
		ANK 5	148..177		11/28 (39%)
		ANK repeat	181..218	CDD:293786	11/38 (29%)
		ANK 6	181..213		8/33 (24%)
		Ank_4	185..240	CDD:290365	17/56 (30%)
		ANK repeat	220..252	CDD:293786	9/31 (29%)
		ANK 7	220..250		8/29 (28%)
		Ank_2	225..319	CDD:289560	28/95 (29%)
		ANK 8	254..283		11/30 (37%)
		ANK repeat	256..286	CDD:293786	12/29 (41%)
		ANK 9	288..317		8/28 (29%)
		ANK repeat	288..313	CDD:293786	7/24 (29%)
		Ank_2	293..387	CDD:289560	33/105 (31%)
		ANK	316..443	CDD:238125	44/140 (31%)
		ANK repeat	321..354	CDD:293786	10/43 (23%)
		ANK 10	321..350		10/33 (30%)
		ANK repeat	356..387	CDD:293786	16/31 (52%)
		ANK 11	356..385		14/29 (48%)
		Ank_2	361..453	CDD:289560	33/94 (35%)
		ANK	384..509	CDD:238125	37/126 (29%)
		ANK repeat	389..420	CDD:293786	9/32 (28%)
		ANK 12	389..418		9/30 (30%)
		ANK repeat	422..453	CDD:293786	9/30 (30%)
		ANK 13	422..451		8/28 (29%)
		Ank_2	427..517	CDD:289560	25/89 (28%)
		ANK repeat	455..486	CDD:293786	12/30 (40%)
		ANK 14	455..484		12/28 (43%)
		ANK 15	488..517		4/28 (14%)
		ANK repeat	488..516	CDD:293786	4/27 (15%)
		D-box 1	490..498		1/7 (14%)
		ANK repeat	521..548	CDD:293786	7/36 (19%)
		ANK 16	523..553		7/39 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	589..833		8/42 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	847..886
		D-box 2	909..917
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	976..999
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	1.870