DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nompC and Ankdd1b

DIOPT Version :9

Sequence 1:	NP_523483.2	Gene:	nompC / 33768	FlyBaseID:	FBgn0016920	Length:	1761	Species:	Drosophila melanogaster
Sequence 2:	XP_006517744.1	Gene:	Ankdd1b / 271144	MGIID:	2444730	Length:	575	Species:	Mus musculus

Alignment Length:	519	Identity:	146/519 - (28%)
Similarity:	215/519 - (41%)	Gaps:	120/519 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   653 MNRQSSVGW---TPLLIACHRGHMELVNNL----------LANHARVDVFDTEGRSALH---LAA 701
            ||.:|:.|.   .|:|.|. ||   |..||          ||...:.:|.|.|..:|.|   ||.
Mouse     1 MNPESAQGHGARAPMLQAA-RG---LKANLRDVATRPWRSLARMPKPEVQDPETAAAGHEGLLAI 61

  Fly   702 ERGY--------LHVCDALLTNKAFINSKSRVGRTALHLAAMNGFTHLVKFLIKDHNAVIDILTL 758
            ||.:        |.:.:.|...|..||:.:.:.|||||.|........|.||: .|.|.:|:...
Mouse    62 ERSFQNAAKSSNLDLMEKLFEKKVNINAVNNMNRTALHFAVGRNSLSAVDFLL-SHKARVDVADK 125

  Fly   759 RKQTPLHLAAASGQMEVCQLLLELGANIDATDDLGQKPIHVAAQNNYSEVAKLFLQQ-HPSLVNA 822
            ...|.:||||.||..|:..:|::.||:..|.:..|...:|:|||||...:....:.. |...:|.
Mouse   126 HGLTVIHLAAWSGSFEIMLMLVKAGADQRAKNQEGMNALHLAAQNNNLHIVDYLIHDLHLHDLNQ 190

  Fly   823 TSKDGNTCAHIAAMQGSVKVIEELMKFDRSGVISARNKLTDATPLQLAAEGGHADVVKALVRAGA 887
            .::.|.                                    .|..||||.||.::::.|:....
Mouse   191 PNERGR------------------------------------KPFHLAAERGHVEMIEKLIFLNL 219

  Fly   888 SCTEENKAGFTAVHLAAQNGHGQVLDVLKSTNSLRINSKKLGLTPLHVAAYYGQADTVRELLTSV 952
            ..:|::|.|.||:||||.:||...:.||              ||         |...|.|
Mouse   220 HTSEKDKDGNTALHLAAMHGHSPAVQVL--------------LT---------QWSEVNE----- 256

  Fly   953 PATVKSETPTGQSLFGDLGTESGMTPLHLAAFSGNENVVRLLLNSAGVQVDAATIENGYN--PLH 1015
                              ..|:|.||..||...|:|...|:|| :.|..|:   |.|..|  .|.
Mouse   257 ------------------SNENGETPFLLAVVGGHEECSRVLL-AGGSDVN---IPNKLNVSALQ 299

  Fly  1016 LACFGGHMSVVGLLLSRSAELLQSQDRNGRTGLHIAAMHGHIQMVEILLGQGAEINATDRNGWTP 1080
            .|...||.::|..||..:|: ||.|..:....||:|.::....:|..||....:::..|:...||
Mouse   300 TATRNGHTALVNFLLGENAD-LQQQKESKEPPLHLAVINNRPAVVNSLLSARHDVDVLDQRRQTP 363

  Fly  1081 LHCAAKAGHLEVVKLLCEAGASPKSETNYGCAAIWFAASEGHNEVLRYLMNKEHDTYGLMEDKR 1144
            ||.||..|::|:|:.|.:||.:.|.....|..|:..||...|:.|:..|:..|. .|...|:.|
Mouse   364 LHVAADLGNVELVETLLKAGCNLKITDKQGKTALAVAARSQHSLVVDMLIKAER-YYAWREEHR 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nompC	NP_523483.2	ANK repeat	129..157	CDD:293786
		Ank_2	131..228	CDD:289560
		ANK	155..319	CDD:238125
		ANK repeat	159..186	CDD:293786
		ANK repeat	232..265	CDD:293786
		Ank_2	237..331	CDD:289560
		ANK	263..387	CDD:238125
		ANK repeat	267..298	CDD:293786
		ANK repeat	300..331	CDD:293786
		Ank_2	305..398	CDD:289560
		ANK	329..454	CDD:238125
		ANK repeat	367..398	CDD:293786
		ANK repeat	400..431	CDD:293786
		Ank_2	405..498	CDD:289560
		ANK	428..555	CDD:238125
		ANK repeat	433..463	CDD:293786
		ANK repeat	469..499	CDD:293786
		ANK	496..641	CDD:238125
		ANK repeat	501..532	CDD:293786
		Ank_2	507..616	CDD:289560
		ANK repeat	534..575	CDD:293786
		ANK repeat	577..616	CDD:293786
		Ank_2	625..722	CDD:289560	28/92 (30%)
		ANK	654..780	CDD:238125	47/149 (32%)
		ANK repeat	660..690	CDD:293786	12/42 (29%)
		ANK repeat	692..723	CDD:293786	12/41 (29%)
		Ank_2	697..790	CDD:289560	34/103 (33%)
		ANK	720..847	CDD:238125	35/127 (28%)
		ANK repeat	725..757	CDD:293786	12/31 (39%)
		ANK repeat	759..790	CDD:293786	12/30 (40%)
		Ank_5	779..834	CDD:290568	14/55 (25%)
		ANK	787..915	CDD:238125	30/128 (23%)
		ANK repeat	792..824	CDD:293786	9/32 (28%)
		ANK repeat	861..893	CDD:293786	9/31 (29%)
		Ank_4	865..915	CDD:290365	19/49 (39%)
		Ank_4	929..995	CDD:290365	14/65 (22%)
		ANK repeat	932..972	CDD:293786	3/39 (8%)
		ANK	969..1096	CDD:238125	43/128 (34%)
		ANK repeat	974..1007	CDD:293786	12/32 (38%)
		Ank_2	979..1074	CDD:289560	29/96 (30%)
		ANK repeat	1009..1041	CDD:293786	12/33 (36%)
		ANK	1039..1159	CDD:238125	32/106 (30%)
		ANK repeat	1043..1074	CDD:293786	6/30 (20%)
		Ank_2	1048..1135	CDD:289560	28/86 (33%)
		ANK repeat	1076..1101	CDD:293786	11/24 (46%)
		ANK repeat	1109..1134	CDD:293786	7/24 (29%)
		Ion_trans	<1393..1598	CDD:278921
Ankdd1b	XP_006517744.1	PHA02876	<63..>413	CDD:165207	119/437 (27%)
		ANK repeat	93..124	CDD:293786	12/31 (39%)
		ANK repeat	126..157	CDD:293786	12/30 (40%)
		ANK repeat	163..192	CDD:293786	8/28 (29%)
		ANK repeat	194..225	CDD:293786	10/66 (15%)
		ANK repeat	227..258	CDD:293786	16/76 (21%)
		ANK repeat	260..291	CDD:293786	13/34 (38%)
		ANK repeat	293..321	CDD:293786	9/28 (32%)
		ANK repeat	330..357	CDD:293786	6/26 (23%)
		ANK repeat	359..390	CDD:293786	13/30 (43%)
		DD	466..>508	CDD:387368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900