DRSC/TRiP Functional Genomics Resources

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Protein Alignment nompC and ANKRD17

DIOPT Version :9

Sequence 1:NP_523483.2 Gene:nompC / 33768 FlyBaseID:FBgn0016920 Length:1761 Species:Drosophila melanogaster
Sequence 2:NP_115593.3 Gene:ANKRD17 / 26057 HGNCID:23575 Length:2603 Species:Homo sapiens


Alignment Length:1546 Identity:361/1546 - (23%)
Similarity:562/1546 - (36%) Gaps:424/1546 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 GGRGGGRGGGVGRKTPSS----------------------------------------LTGPPD- 29
            ||.|||.|||.|..|.|:                                        |:|..| 
Human    97 GGGGGGGGGGGGGGTSSNNSEEEEDDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADG 161

  Fly    30 ------------------ESATPSERATPASKADSDP------------------------KDDS 52
                              |:|...:.:|...||.:||                        :.:|
Human   162 ADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAES 226

  Fly    53 SSNGDKKDM----------DLFPAPKPPSAGASIR---DTANKVLGLAMKSEWTPIEAELKKLEK 104
            ::|..:.|.          |:....|....|.|:.   :....:|.||..:.:..:...|..:..
Human   227 TANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHA 291

  Fly   105 YVANVGEDGNHIPLAGVHDMNTGMTPLMYATKDNKTAIMDRMIELGADVGARNNDNYNVLHIAAM 169
            .|.:.|..|:             :||||.|.......|:..::...|||.|:::.....|..|..
Human   292 NVEDRGIKGD-------------ITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACA 343

  Fly   170 YSREDVVKLLL---------TKRGVDPFSTGGSRSQTAVHLVSSRQTGTATNILRALLAAAGKDI 225
            ....||||:||         .:.|..|....||    |.|:..:|           ||...|..|
Human   344 GGYVDVVKVLLESGASIEDHNENGHTPLMEAGS----AGHVEVAR-----------LLLENGAGI 393

  Fly   226 RLKADGRGKIPLLLAVESGNQSMCRELLAAQTAEQLKATTANGDTALHLAARRRDVDMVRILVDY 290
            ...::...:..|.||...|:..|.|.||.|...::.|  |....|||..|.....|::.|:|:|.
Human   394 NTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHK--TDEMHTALMEACMDGHVEVARLLLDS 456

  Fly   291 GTNVDTQNGEGQTPLHIAAAEGDEALLKYFYGVRASASIADNQDRTPMHLAAENGHAHVIEILAD 355
            |..|:......::||.:||..|...|........||....:::..||:..||..||..::.:|..
Human   457 GAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLG 521

  Fly   356 KFKASIFERTKD-GSTLMHIASLNGHAECATMLFKKGVYLHMPNKDGARS-IHTAAAYGHTGIIN 418
            : .|:|..:|:: ..|.:.:|...|..|.|..|.|.|..:.:    |..: :..||..||..::.
Human   522 Q-GANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL----GCSTPLMEAAQEGHLELVK 581

  Fly   419 TLLQKGEKVDVTTNDNYTALHIAVESAKPAVVETLLGFGADV--HVRGGKLRETPLHIAARVKDG 481
            .||..|..|..||....|||..|.|:....|.:.||..|||:  ...||:   |||..|||.  |
Human   582 YLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGR---TPLMKAARA--G 641

  Fly   482 DRCAL-MLLKSGASPNLTT-DDCLTPVHVAARHGNLATLMQLLEDEGDPLYKSNTGETPLHMACR 544
            ..|.: .|:..||:.|.|| ::..|.:.:|...|:||.:..||....||.::...|.|.|..|.:
Human   642 HVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAK 706

  Fly   545 ACHPDIVRHLIE-----------------------------------TVKEKHGPDK-----ATT 569
            ..|..:|.:|::                                   .|.....|||     |||
Human   707 GGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATT 771

  Fly   570 --------------------------YI-----NSVNEDG----------------------ATA 581
                                      ||     .|:.|:.                      :..
Human   772 LPIRNKAASKQKSSSHLPANSQDVQGYITNQSPESIVEEAQGKLTELEQRIKEAIEKNAQLQSLE 836

  Fly   582 LHYTCQITKEEV----KIPESDKQIVRMLLENGADV--TLQTKTALETAFHYCAVAGNNDVLMEM 640
            |.:..|:|||::    |..|...|..:.:||....|  .||.||..:....|..|......|.:.
Human   837 LAHADQLTKEKIEELNKTREEQIQKKQKILEELQKVERELQLKTQQQLKKQYLEVKAQRIQLQQQ 901

  Fly   641 -------ISHMNPTDIQKAMNR---------------------QSSVGWTPLLIACHRGHMELVN 677
                   :..:.|..:.:.::.                     .:.:|:.|:........:.|..
Human   902 QQQSCQHLGLLTPVGVGEQLSEGDYARLQQVDPVLLKDEPQQTAAQMGFAPIQPLAMPQALPLAA 966

  Fly   678 NLLANHARVDVFDTEG----------------RSALHLAAERGYLHVCDALLTNKAFINSKSRV- 725
            ..|...:..::.:.:|                ...:....::|.:....|...|....:..:.| 
Human   967 GPLPPGSIANLTELQGVIVGQPVLGQAQLAGLGQGILTETQQGLMVASPAQTLNDTLDDIMAAVS 1031

  Fly   726 GRTALHLAAMNGFTHLVKFLIKDHNA-----------------VIDI---LTLRKQTPLHLAAAS 770
            ||.:   |..|..||.:...|.....                 .|||   ......|.|.||.|.
Human  1032 GRAS---AMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAG 1093

  Fly   771 GQMEVCQLLLELGANIDATDDLGQKPIHVAAQNNYSEVAKLFLQQHPSLVNATSKDGNTCAHIAA 835
            |..|:.|.|||.||:|:..|..|..|:.:||                           |..|:. 
Human  1094 GHEELVQTLLERGASIEHRDKKGFTPLILAA---------------------------TAGHVG- 1130

  Fly   836 MQGSVKVIEELMKFDRSGVISARNKLTDATPLQLAAEGGHADVVKALVRAGASCTEENKAGFTAV 900
                  |:|.|:  |....|.|:::.|..|||.||..||..:||:.|:..||:....|.:.:|.:
Human  1131 ------VVEILL--DNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPL 1187

  Fly   901 HLAAQNGHGQVLDVLKSTNSLRINSK---KLGLTPLHVAAYYGQADTVRELLTSVPATVKSETPT 962
            .|||..|:..::.:|.:..: .|||:   |||::||.:||..|....|: ||..:.:.:.::..|
Human  1188 SLAASGGYVNIIKILLNAGA-EINSRTGSKLGISPLMLAAMNGHTAAVK-LLLDMGSDINAQIET 1250

  Fly   963 GQSLFGDLGTESGMTPLHLAAFSGNENVVRLLLN-SAGVQVDAATIENGYNPLHLACFGGHMSVV 1026
            .::           |.|.||.|.|...||.|||: .|.|:..|.|   |..||..|..||:..|.
Human  1251 NRN-----------TALTLACFQGRTEVVSLLLDRKANVEHRAKT---GLTPLMEAASGGYAEVG 1301

  Fly  1027 GLLLSRSAELLQSQDRNGR-TGLHIAAMHGHIQMVEILLGQGAEINATDRNGWTPLHCAAKAGHL 1090
            .:||.:.|::......:.| |.|.|||..||.:..|:|:|:||.|:..::.|.|||..||..|||
Human  1302 RVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHL 1366

  Fly  1091 EVVKLLCEAGASPKSETNYGCAAIWFAASEGHNEVLRYLMNKEHDTYGLMEDKRFVYNLMVVSKN 1155
            :||:||.:|||...:..|.....:..|..:||.:|:|||:.:.:......|..|::         
Human  1367 DVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYI--------- 1422

  Fly  1156 HNNKPIQEFVLVSPAPVDTAAKLSNIYIVLSTKEKERAKDLVAAGKQCEAMATEL---------- 1210
                          |.:.....|...::.:.:..:.:.:....|.|....:..||          
Human  1423 --------------ATITDKEMLKKCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESR 1473

  Fly  1211 -LALAA------------GSDSAGKI--LQATDKRNVEFLDVLIENEQKEV 1246
             |||||            ..:...|:  ::|.:|.|.| |....|.|:.:|
Human  1474 RLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKENFE-LQAAQEKEKLKV 1523

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nompCNP_523483.2 ANK repeat 129..157 CDD:293786 10/27 (37%)
Ank_2 131..228 CDD:289560 27/105 (26%)
ANK 155..319 CDD:238125 47/172 (27%)
ANK repeat 159..186 CDD:293786 9/35 (26%)
ANK repeat 232..265 CDD:293786 10/32 (31%)
Ank_2 237..331 CDD:289560 29/93 (31%)
ANK 263..387 CDD:238125 34/124 (27%)
ANK repeat 267..298 CDD:293786 10/30 (33%)
ANK repeat 300..331 CDD:293786 8/30 (27%)
Ank_2 305..398 CDD:289560 25/93 (27%)
ANK 329..454 CDD:238125 35/126 (28%)
ANK repeat 367..398 CDD:293786 8/31 (26%)
ANK repeat 400..431 CDD:293786 9/31 (29%)
Ank_2 405..498 CDD:289560 35/95 (37%)
ANK 428..555 CDD:238125 44/130 (34%)
ANK repeat 433..463 CDD:293786 11/31 (35%)
ANK repeat 469..499 CDD:293786 12/30 (40%)
ANK 496..641 CDD:238125 48/251 (19%)
ANK repeat 501..532 CDD:293786 9/30 (30%)
Ank_2 507..616 CDD:289560 37/207 (18%)
ANK repeat 534..575 CDD:293786 17/111 (15%)
ANK repeat 577..616 CDD:293786 11/66 (17%)
Ank_2 625..722 CDD:289560 12/140 (9%)
ANK 654..780 CDD:238125 27/183 (15%)
ANK repeat 660..690 CDD:293786 4/29 (14%)
ANK repeat 692..723 CDD:293786 4/46 (9%)
Ank_2 697..790 CDD:289560 28/113 (25%)
ANK 720..847 CDD:238125 34/147 (23%)
ANK repeat 725..757 CDD:293786 11/52 (21%)
ANK repeat 759..790 CDD:293786 14/30 (47%)
Ank_5 779..834 CDD:290568 13/54 (24%)
ANK 787..915 CDD:238125 32/127 (25%)
ANK repeat 792..824 CDD:293786 4/31 (13%)
ANK repeat 861..893 CDD:293786 13/31 (42%)
Ank_4 865..915 CDD:290365 18/49 (37%)
Ank_4 929..995 CDD:290365 19/65 (29%)
ANK repeat 932..972 CDD:293786 9/39 (23%)
ANK 969..1096 CDD:238125 50/128 (39%)
ANK repeat 974..1007 CDD:293786 14/33 (42%)
Ank_2 979..1074 CDD:289560 38/96 (40%)
ANK repeat 1009..1041 CDD:293786 10/31 (32%)
ANK 1039..1159 CDD:238125 40/120 (33%)
ANK repeat 1043..1074 CDD:293786 14/31 (45%)
Ank_2 1048..1135 CDD:289560 36/86 (42%)
ANK repeat 1076..1101 CDD:293786 14/24 (58%)
ANK repeat 1109..1134 CDD:293786 7/24 (29%)
Ion_trans <1393..1598 CDD:278921
ANKRD17NP_115593.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..143 11/45 (24%)
ANK 1 233..262 5/28 (18%)
Ank_2 238..330 CDD:289560 20/104 (19%)
ANK repeat 238..264 CDD:293786 4/25 (16%)
ANK 261..387 CDD:238125 33/153 (22%)
ANK repeat 266..298 CDD:293786 5/31 (16%)
ANK 2 266..295 5/28 (18%)
ANK 3 300..329 10/41 (24%)
ANK repeat 303..331 CDD:293786 10/27 (37%)
Ank_2 305..394 CDD:289560 26/103 (25%)
ANK 328..454 CDD:238125 37/142 (26%)
ANK repeat 333..364 CDD:293786 8/30 (27%)
ANK 4 333..362 8/28 (29%)
ANK 5 366..395 11/43 (26%)
ANK repeat 366..394 CDD:293786 10/42 (24%)
ANK 396..520 CDD:238125 35/125 (28%)
ANK repeat 400..431 CDD:293786 10/32 (31%)
ANK 6 400..429 9/28 (32%)
Ank_4 403..454 CDD:290365 17/52 (33%)
ANK 7 433..462 10/28 (36%)
ANK repeat 435..464 CDD:293786 10/28 (36%)
Ank_2 438..529 CDD:289560 25/91 (27%)
ANK repeat 466..497 CDD:293786 8/30 (27%)
ANK 8 466..495 8/28 (29%)
ANK repeat 499..529 CDD:293786 9/30 (30%)
ANK 9 499..528 9/29 (31%)
ANK repeat 532..561 CDD:293786 8/28 (29%)
ANK 10 533..562 8/28 (29%)
Ank_4 536..584 CDD:290365 13/51 (25%)
ANK 11 563..592 9/28 (32%)
ANK 566..684 CDD:238125 42/122 (34%)
ANK repeat 566..594 CDD:293786 8/27 (30%)
Ank_2 568..659 CDD:289560 35/95 (37%)
ANK repeat 596..627 CDD:293786 11/30 (37%)
ANK 12 596..625 11/28 (39%)
ANK repeat 629..658 CDD:293786 13/33 (39%)
ANK 13 629..658 13/33 (39%)
Ank_2 634..723 CDD:289560 28/90 (31%)
ANK 662..>723 CDD:238125 16/60 (27%)
ANK repeat 663..693 CDD:293786 9/29 (31%)
ANK 14 663..692 9/28 (32%)
ANK 15 696..725 7/28 (25%)
OmpH 794..>893 CDD:281871 21/98 (21%)
AhaH 805..881 CDD:131972 16/75 (21%)
ANKYR 1046..1272 CDD:223738 75/274 (27%)
ANK 16 1082..1111 14/28 (50%)
ANK 1082..1110 CDD:197603 13/27 (48%)
ANK repeat 1084..1113 CDD:293786 14/28 (50%)
ANK 1111..1238 CDD:238125 46/164 (28%)
ANK repeat 1115..1147 CDD:293786 12/67 (18%)
ANK 17 1115..1144 11/64 (17%)
ANK repeat 1149..1180 CDD:293786 13/30 (43%)
ANK 18 1149..1178 13/28 (46%)
ANK repeat 1182..1213 CDD:293786 9/31 (29%)
ANK 19 1182..1211 7/29 (24%)
ANK repeat 1217..1247 CDD:293786 10/30 (33%)
ANK 20 1217..1246 10/29 (34%)
ANK repeat 1250..1282 CDD:293786 14/42 (33%)
ANK 21 1251..1280 13/39 (33%)
ANK 1280..1406 CDD:238125 49/128 (38%)
ANK repeat 1284..1313 CDD:293786 11/31 (35%)
ANK 22 1284..1313 11/31 (35%)
Ank_2 1289..1383 CDD:289560 38/93 (41%)
ANK 23 1319..1348 14/28 (50%)
ANK repeat 1321..1350 CDD:293786 13/28 (46%)
ANK repeat 1352..1383 CDD:293786 16/30 (53%)
ANK 24 1352..1381 16/28 (57%)
ANK 25 1385..1414 7/28 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1479..1500 2/20 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1517..1717 3/7 (43%)
NusA <1720..1767 CDD:223273
KH-I 1727..1789 CDD:238053
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1906..1995
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2011..2192
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2273..2332
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2381..2423
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1115202at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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