DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nompC and Ankrd65

DIOPT Version :9

Sequence 1:	NP_523483.2	Gene:	nompC / 33768	FlyBaseID:	FBgn0016920	Length:	1761	Species:	Drosophila melanogaster
Sequence 2:	NP_001357751.1	Gene:	Ankrd65 / 242805	MGIID:	2685285	Length:	364	Species:	Mus musculus

Alignment Length:	479	Identity:	135/479 - (28%)
Similarity:	195/479 - (40%)	Gaps:	133/479 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   638 MEMISHMNPTDIQKAMNRQSSVGWTPLLIACHRGHMELVNNLLANHARVDVFDTEGRSALHLAAE 702
            |:::....|.|  |.....:|.||:.|..|...|...||..||          .:|.|
Mouse    13 MKLVWEEAPAD--KTERPLTSPGWSTLFQAVWWGAPSLVMQLL----------RQGSS------- 58

  Fly   703 RGYLHVCDALLTNKAFINSKSRVGRTALHLAAMNGFTHLVKFLIKDHNAVIDILTLRKQTPLHLA 767
                            :..:...|||.||||.|.|...||:
Mouse    59 ----------------VEERDHTGRTPLHLAVMRGHAPLVR------------------------ 83

  Fly   768 AASGQMEVCQLLLELGANIDATDDLGQKPIHVAAQNNYSEVAKLFLQQHPSLVNATSKDGNTCAH 832
                      |||:.||...|.|..|:.|:|.||.:.:|.||:|.|::..|.. |.|:.|.|..|
Mouse    84 ----------LLLQRGALAGAPDHTGRTPLHEAAWHGHSNVAELLLRRGASAA-ACSQTGLTPLH 137

  Fly   833 IAAMQGSVKVIEELMKFDRSGVISARNKLTDATPLQLAAEGGHADVVKALVRAGASCTEENKAGF 897
            .||..|...::                     |...:|::.| :||             ::..|:
Mouse   138 GAAALGRTLLV---------------------TSFTVASDSG-SDV-------------KDVRGW 167

  Fly   898 TAVHLAAQNGHGQVLDVLKSTNSLRINSKKLGLTPLHVAAYYGQADTVRELLTSVPATVKSETPT 962
            ||.|.||..|...||::|.:..:..::...|      |:|..|...:::.||| :.|.|.::..|
Mouse   168 TAAHWAAACGQLAVLELLSAGGNADLDGALL------VSAIAGSTSSLQLLLT-LGAKVDTQDST 225

  Fly   963 GQSLFGDLGTESGMTPLHLAAFSGNENVVRLLLNSAGVQVDAATIENGYNPLHLACFGGHMSVVG 1027
                        |.|.|.|||..|:...:.:||:. |...:... .|..:.||.|..|||:.|..
Mouse   226 ------------GATALGLAAGLGHHQDIEVLLDH-GADPNIRD-RNNRSALHRAATGGHLRVTQ 276

  Fly  1028 LLLSRSAELLQSQDRNGRTGLHIAAMHGHIQMVEILLGQGAEINATDRNGW---TPLHCAAKAGH 1089
            ||:::..| :.:||..|.|.||.||..||:::|..||.:||.|||.   ||   ||||.|.:.||
Mouse   277 LLVAKGIE-IDAQDSLGLTPLHHAARGGHVEVVSHLLDRGAHINAA---GWLHKTPLHLAVENGH 337

  Fly  1090 LEVVKLLCEAGASPKSETNYGCAA 1113
            ...|:||...||:....|.:|.||
Mouse   338 STTVELLLSRGANSTLRTQWGEAA 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nompC	NP_523483.2	ANK repeat	129..157	CDD:293786
		Ank_2	131..228	CDD:289560
		ANK	155..319	CDD:238125
		ANK repeat	159..186	CDD:293786
		ANK repeat	232..265	CDD:293786
		Ank_2	237..331	CDD:289560
		ANK	263..387	CDD:238125
		ANK repeat	267..298	CDD:293786
		ANK repeat	300..331	CDD:293786
		Ank_2	305..398	CDD:289560
		ANK	329..454	CDD:238125
		ANK repeat	367..398	CDD:293786
		ANK repeat	400..431	CDD:293786
		Ank_2	405..498	CDD:289560
		ANK	428..555	CDD:238125
		ANK repeat	433..463	CDD:293786
		ANK repeat	469..499	CDD:293786
		ANK	496..641	CDD:238125	1/2 (50%)
		ANK repeat	501..532	CDD:293786
		Ank_2	507..616	CDD:289560
		ANK repeat	534..575	CDD:293786
		ANK repeat	577..616	CDD:293786
		Ank_2	625..722	CDD:289560	16/83 (19%)
		ANK	654..780	CDD:238125	24/125 (19%)
		ANK repeat	660..690	CDD:293786	9/29 (31%)
		ANK repeat	692..723	CDD:293786	2/30 (7%)
		Ank_2	697..790	CDD:289560	17/92 (18%)
		ANK	720..847	CDD:238125	37/126 (29%)
		ANK repeat	725..757	CDD:293786	11/31 (35%)
		ANK repeat	759..790	CDD:293786	6/30 (20%)
		Ank_5	779..834	CDD:290568	22/54 (41%)
		ANK	787..915	CDD:238125	35/127 (28%)
		ANK repeat	792..824	CDD:293786	12/31 (39%)
		ANK repeat	861..893	CDD:293786	5/31 (16%)
		Ank_4	865..915	CDD:290365	14/49 (29%)
		Ank_4	929..995	CDD:290365	16/65 (25%)
		ANK repeat	932..972	CDD:293786	9/39 (23%)
		ANK	969..1096	CDD:238125	49/129 (38%)
		ANK repeat	974..1007	CDD:293786	10/32 (31%)
		Ank_2	979..1074	CDD:289560	37/94 (39%)
		ANK repeat	1009..1041	CDD:293786	11/31 (35%)
		ANK	1039..1159	CDD:238125	36/78 (46%)
		ANK repeat	1043..1074	CDD:293786	16/30 (53%)
		Ank_2	1048..1135	CDD:289560	32/69 (46%)
		ANK repeat	1076..1101	CDD:293786	12/27 (44%)
		ANK repeat	1109..1134	CDD:293786	3/5 (60%)
		Ion_trans	<1393..1598	CDD:278921
Ankrd65	NP_001357751.1	ANK repeat	33..63	CDD:293786	11/62 (18%)
		PHA03095	49..>347	CDD:222980	118/425 (28%)
		ANK repeat	65..96	CDD:293786	17/64 (27%)
		ANK repeat	98..123	CDD:293786	10/24 (42%)
		ANK repeat	165..223	CDD:293786	19/64 (30%)
		ANK repeat	226..256	CDD:293786	10/30 (33%)
		ANK repeat	258..289	CDD:293786	11/31 (35%)
		ANK repeat	291..320	CDD:293786	14/28 (50%)
		ANK repeat	324..354	CDD:293786	12/29 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810