DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nompC and Ankle1

DIOPT Version :9

Sequence 1:	NP_523483.2	Gene:	nompC / 33768	FlyBaseID:	FBgn0016920	Length:	1761	Species:	Drosophila melanogaster
Sequence 2:	NP_766344.2	Gene:	Ankle1 / 234396	MGIID:	1918775	Length:	534	Species:	Mus musculus

Alignment Length:	192	Identity:	56/192 - (29%)
Similarity:	79/192 - (41%)	Gaps:	39/192 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   441 AVESAKPAVVETLLGFGADVHV---RGGKLRETPLHIAARVKD--GDRCALMLLKSGASPNLTTD 500
            |:...:...||.||..|||.::   .|.    ..:|:|||...  ...|..|||:.||.||..:.
Mouse    14 ALREEEARAVEELLRLGADPNLVLDDGA----AAVHLAARASHPRALHCLRMLLRWGADPNARSA 74

  Fly   501 DCLTPVHVAARHGNLATLMQLLEDEGDPLYKSNTGETPLHMACRACH---------------PDI 550
            :.||||||||..|....|..||...|||..:...|..||..|.:..|               ||.
Mouse    75 EGLTPVHVAAAWGCCGALELLLSRGGDPTLRDQDGLRPLDWALQQRHHNCARVLQELDTPTQPDE 139

  Fly   551 VRHLIET---------VKEKHGPDKATTYINSVNEDGATALHYTCQITKEEVKI---PESDK 600
            .|...||         .:...||..|.:  :.|::|....:| ..::..|.|::   |:|.:
Mouse   140 TREPTETFHVAQGSFETETCQGPALAES--SGVSQDSELHVH-RAELEVEAVEVAVHPQSSE 198

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nompC	NP_523483.2	ANK repeat	129..157	CDD:293786
		Ank_2	131..228	CDD:289560
		ANK	155..319	CDD:238125
		ANK repeat	159..186	CDD:293786
		ANK repeat	232..265	CDD:293786
		Ank_2	237..331	CDD:289560
		ANK	263..387	CDD:238125
		ANK repeat	267..298	CDD:293786
		ANK repeat	300..331	CDD:293786
		Ank_2	305..398	CDD:289560
		ANK	329..454	CDD:238125	3/12 (25%)
		ANK repeat	367..398	CDD:293786
		ANK repeat	400..431	CDD:293786
		Ank_2	405..498	CDD:289560	21/61 (34%)
		ANK	428..555	CDD:238125	44/133 (33%)
		ANK repeat	433..463	CDD:293786	8/24 (33%)
		ANK repeat	469..499	CDD:293786	12/31 (39%)
		ANK	496..641	CDD:238125	36/132 (27%)
		ANK repeat	501..532	CDD:293786	15/30 (50%)
		Ank_2	507..616	CDD:289560	31/121 (26%)
		ANK repeat	534..575	CDD:293786	13/64 (20%)
		ANK repeat	577..616	CDD:293786	6/27 (22%)
		Ank_2	625..722	CDD:289560
		ANK	654..780	CDD:238125
		ANK repeat	660..690	CDD:293786
		ANK repeat	692..723	CDD:293786
		Ank_2	697..790	CDD:289560
		ANK	720..847	CDD:238125
		ANK repeat	725..757	CDD:293786
		ANK repeat	759..790	CDD:293786
		Ank_5	779..834	CDD:290568
		ANK	787..915	CDD:238125
		ANK repeat	792..824	CDD:293786
		ANK repeat	861..893	CDD:293786
		Ank_4	865..915	CDD:290365
		Ank_4	929..995	CDD:290365
		ANK repeat	932..972	CDD:293786
		ANK	969..1096	CDD:238125
		ANK repeat	974..1007	CDD:293786
		Ank_2	979..1074	CDD:289560
		ANK repeat	1009..1041	CDD:293786
		ANK	1039..1159	CDD:238125
		ANK repeat	1043..1074	CDD:293786
		Ank_2	1048..1135	CDD:289560
		ANK repeat	1076..1101	CDD:293786
		ANK repeat	1109..1134	CDD:293786
		Ion_trans	<1393..1598	CDD:278921
Ankle1	NP_766344.2	ANK 1. /evidence=ECO:0000255	4..35		8/20 (40%)
		ANK	26..128	CDD:238125	38/105 (36%)
		Ank_2	26..106	CDD:289560	33/83 (40%)
		ANK 2. /evidence=ECO:0000255	39..71		12/35 (34%)
		ANK repeat	75..106	CDD:293786	15/30 (50%)
		ANK 3. /evidence=ECO:0000255	75..104		15/28 (54%)
		Ank_4	76..128	CDD:290365	20/51 (39%)
		ANK 4. /evidence=ECO:0000255	108..137		5/28 (18%)
		LEM	285..322	CDD:295412
		GIY-YIG_COG3680_Meta	372..484	CDD:198401
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q8NAG6	498..505
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900